Attenuation correction of SPECT using x-ray CT on an emission-transmission CT system: Myocardial perfusion assessment

Journal Article · Thu Aug 01 04:00:00 EDT 1996 · IEEE Transactions on Nuclear Science

DOI:https://doi.org/10.1109/23.531891· OSTI ID:379766

Blankespoor, S C; Wu, X; Kalki, K; Brown, J K; Tang, H R; Cann, C E; Hasegawa, B H ^[1]

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1. Univ. of California, San Francisco, CA (United States)

The authors present experimental results for attenuation correction of emission tomography through use of an attenuation map derived from X-ray CT data. The X-ray and gamma-ray data were obtained from a third-generation X-ray CT scanner and a single-headed SPECT scanner juxtaposed to enable systematic registration of SPECT and X-ray CT images. CT measurements were obtained from known materials at a given X-ray technique, then related to attenuation coefficients at 140 keV. The resulting calibration data were used to generate attenuation maps for the coregistered SPECT data. In addition, phantom studies provided recovery coefficients as a function of object size to compensate for partial volume effects in the coregistered radionuclide data. This technique has been applied to a torso phantom, yielding attenuation maps with an average accuracy error < 1%. Reconstruction of the SPECT image without attenuation correction underestimated the regional myocardial activity errors with an average accuracy error of {minus}90%. Reconstruction with attenuation correction reduced the average accuracy error to {minus}37%, but addition of a partial volume correction overestimated the regional myocardial activity concentration by an average error of 94%.

• OSTI ID: 379766
• Report Number(s): CONF-951073--
• Journal Information: IEEE Transactions on Nuclear Science, Journal Name: IEEE Transactions on Nuclear Science Journal Issue: 4Pt1 Vol. 43; ISSN 0018-9499; ISSN IETNAE
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
COMPUTERIZED TOMOGRAPHY
CORRECTIONS
EXPERIMENTAL DATA
GAMMA RADIATION
IMAGE PROCESSING
MYOCARDIUM
RADIOISOTOPE SCANNERS
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
X RADIATION