Object-specific attenuation correction of SPECT with correlated dual-energy X-ray CT

Journal Article · Sun Aug 01 04:00:00 EDT 1993 · IEEE Transactions on Nuclear Science (Institute of Electrical and Electronics Engineers); (United States)

OSTI ID:5695718

Hasegawa, B H; Brown, J K; Blankespoor, S C ^[1]; Lang, T F ^[2]; Reilly, S M ^[3]; Liew, S C ^[4]; Tsui, B M.W. ^[5]; Ramanathan, C ^[6]

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1. UCSF Physics Research Lab., San Francisco, CA (United States). Dept. of Radiology and Bioengineering Graduate Group
2. ADAC Labs., Milpitas, CA (United States)
3. Imatron Inc., San Francisco, CA (United States)
4. National Univ. of Singapore, (Singapore). Dept. of Physics
5. Univ. of North Carolina, Chapel Hill, NC (United States). Dept. of Biomedical Engineering and Radiology
6. Massachusetts Inst. of Tech., Cambridge, MA (United States). Dept. of Health Sciences and Technology

The authors have developed a prototype emission-transmission computed tomographic (ETCT) system, which can acquire both radionuclide-emission and dual-energy X-ray transmission data. The dual-energy X-ray data are used to synthesize an object and energy-specific attenuation map which is incorporated into an ML-EM algorithm to reconstruct an attenuation corrected SPECT image. The technique was applied to a thoraxlike phantom with regions simulating lung, background and cardiac regions, and bone. SPECT images reconstructed with no attenuation correction, or with a uniform water-equivalent map, contained increased count levels in the lung region and reduced count levels in the cardiac region as compared with the radioactivity concentrations contained in the phantom. Use of an object-specific attenuation map improved the accuracy of the reconstruction, but overestimated the activity in the cardiac chamber by about 10%. This error was reduced to about 5% when the attenuation coefficients were modified to include the effects of scattered radiation.

• OSTI ID: 5695718
• Journal Information: IEEE Transactions on Nuclear Science (Institute of Electrical and Electronics Engineers); (United States), Journal Name: IEEE Transactions on Nuclear Science (Institute of Electrical and Electronics Engineers); (United States) Vol. 40:4; ISSN 0018-9499; ISSN IETNAE
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALGORITHMS
ATTENUATION
BODY
CARDIOVASCULAR SYSTEM
COMPUTERIZED TOMOGRAPHY
CORRECTIONS
DIAGNOSTIC TECHNIQUES
ELECTROMAGNETIC RADIATION
EMISSION COMPUTED TOMOGRAPHY
ERRORS
HEART
IMAGE PROCESSING
IONIZING RADIATIONS
ISOTOPES
LUNGS
MATHEMATICAL LOGIC
MOCKUP
ORGANS
PHANTOMS
PROCESSING
RADIATIONS
RADIOISOTOPES
RESPIRATORY SYSTEM
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
SKELETON
STRUCTURAL MODELS
TOMOGRAPHY
UPTAKE
X RADIATION