Myocardial perfusion imaging with a correlated X-ray CT and SPECT system: An animal study

Journal Article · Sat Jun 01 04:00:00 EDT 1996 · IEEE Transactions on Nuclear Science

DOI:https://doi.org/10.1109/23.507260· OSTI ID:267972

Kalki, K; Brown, J K; Blankespoor, S C; Hasegawa, B H; Dae, M W; Chin, M; Stillson, C A ^[1]

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1. Univ. of California, San Francisco, CA (United States)

The authors performed a quantitative SPECT study in a porcine model of myocardial perfusion with the correlated X-way CT transmission and SPECT emission (ETCT) system developed at UCSF. Pixel values in the reconstructed SPECT images were calibrated in units of activity concentration and compared with the activity concentration and compared with the activity concentration determined from corresponding excised myocardial tissue samples. An object specific attenuation map was obtained by linear scaling from the X-ray CT. Attenuation maps with lower spatial resolution and higher signal-to-noise ratio were also derived from the C-ray CT image. The pixel values and intensity distribution in reconstructed myocardial SPECT image was not sensitive to spatial resolution or noise in the transmission map for the given examples. An MLEM algorithm with regularization was used to determine mean and maximum pixel values for ROIs in the myocardial SPECT images. The use of the maximum pixel value did not sufficiently compensate for contrast degradation due to partial volume errors. A separate measurement of the myocardial wall thickness was used to adequately correct for partial volume errors.

• OSTI ID: 267972
• Report Number(s): CONF-951073--
• Journal Information: IEEE Transactions on Nuclear Science, Journal Name: IEEE Transactions on Nuclear Science Journal Issue: 3Pt2 Vol. 43; ISSN 0018-9499; ISSN IETNAE
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
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DATA COVARIANCES
EMISSION COMPUTED TOMOGRAPHY
IMAGE PROCESSING
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PERFUSED TISSUES
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
SWINE