The rad18 gene of Schizosaccharomyces pombe defines a new subgroup of the SMC superfamily involved in DNA repair

Journal Article · Fri Dec 01 04:00:00 EST 1995 · Molecular and Cellular Biology

DOI:https://doi.org/10.1128/MCB.15.12.7067· OSTI ID:379284

Lehmann, A R; Walicka, M; Griffiths, D J.F.; Carr, A M ^[1]

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1. Univ. of Oxford (United Kingdom); and others

This report describes the cloning and sequencing of the rad18 gene of Schizosaccharomyces pombe and its essential role in cell proliferation. It also describes the isolation and sequencing of its homolog from Saccharomyces cerevisiae, designated RHC18. Genetic radiation effects were explored and results indicate the gene product`s importance in a DNA repair pathway that is distinct from classical nucleotide excision repair. 57 refs., 20 figs., 1 tab.

• Sponsoring Organization: USDOE
• OSTI ID: 379284
• Journal Information: Molecular and Cellular Biology, Journal Name: Molecular and Cellular Biology Journal Issue: 12 Vol. 15; ISSN 0270-7306; ISSN MCEBD4
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
56 BIOLOGY AND MEDICINE
APPLIED STUDIES
BIOLOGICAL EVOLUTION
CELL CYCLE
CELL KILLING
CELL PROLIFERATION
DNA
DNA REPAIR
DNA SEQUENCING
DNA-CLONING
GAMMA RADIATION
GENE MUTATIONS
GENES
GENETIC RADIATION EFFECTS
NUCLEOTIDES
PROTEINS
SACCHAROMYCES CEREVISIAE
STRUCTURE-ACTIVITY RELATIONSHIPS
SURVIVAL CURVES
ULTRAVIOLET RADIATION