Method for rapid base sequencing in DNA and RNA with two base labeling
Patent
·
OSTI ID:35063
A method is described for rapid-base sequencing in DNA and RNA with two-base labeling and employing fluorescent detection of single molecules at two wavelengths. Bases modified to accept fluorescent labels are used to replicate a single DNA or RNA strand to be sequenced. The bases are then sequentially cleaved from the replicated strand, excited with a chosen spectrum of electromagnetic radiation, and the fluorescence from individual, tagged bases detected in the order of cleavage from the strand. 4 figures.
- Research Organization:
- University of California
- DOE Contract Number:
- W-7405-ENG-36
- Assignee:
- Univ. of California Office of Technology Transfer, Alameda, CA (United States)
- Patent Number(s):
- US 5,405,747/A/
- Application Number:
- PAN: 8-208,506
- OSTI ID:
- 35063
- Country of Publication:
- United States
- Language:
- English
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