Cation exchange separation of radium and actinium using lactic acid DTPA buffer

Kmak, Kelly N.; Despotopulos, John D.; Huynh, Tony L.

doi:10.1007/s10967-025-10520-5

Cation exchange separation of radium and actinium using lactic acid DTPA buffer

Journal Article · Tue Nov 11 00:00:00 UTC 2025 · Journal of Radioanalytical and Nuclear Chemistry

DOI:https://doi.org/10.1007/s10967-025-10520-5· OSTI ID:3003462

^[1]; Despotopulos, John D. ^[1]; Huynh, Tony L. ^[1]

Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

The separation of actinium (²²⁸Ac) from radium (^223,228Ra) on cation exchange resin with a diethylenetriaminpentaacetic acid-lactate buffer solution is demonstrated with series of columns. High yield, high radiopurity (~ 100%) separations of Ac from Ra are feasible with small columns in biologically compatible conditions and pHs. As Ac is eluted before Ra on these columns, further studies were performed to determine if this separation system could be applied to Ra/Ac isotope generators, but these were not successful. In conclusion, the separations presented in this work may be relevant for radiopharmaceutical purifications of ²²⁵Ac which is typically obtained from its ²²⁵Ra parent isotope.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Organization:: USDOE National Nuclear Security Administration (NNSA)

Grant/Contract Number:: AC52-07NA27344

OSTI ID:: 3003462

Report Number(s):: LLNL--JRNL-2010411

Journal Information:: Journal of Radioanalytical and Nuclear Chemistry, Journal Name: Journal of Radioanalytical and Nuclear Chemistry; ISSN 1588-2780; ISSN 0236-5731

Publisher:: SpringerCopyright Statement

Country of Publication:: United States

Language:: English

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and nuclear chemistry
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Cation exchange separation of radium and actinium using lactic acid DTPA buffer

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