The application of poorly crystalline silicotitanate in production of 225Ac

Fitzsimmons, Jonathan; Abraham, Alyson; Catalano, Demetra; Younes, Ali; Cutler, Cathy S.; Medvedev, Dmitri

doi:10.1038/s41598-019-48021-7

The application of poorly crystalline silicotitanate in production of ²²⁵Ac

Journal Article · Wed Aug 14 00:00:00 EDT 2019 · Scientific Reports

DOI:https://doi.org/10.1038/s41598-019-48021-7· OSTI ID:1547020

Fitzsimmons, Jonathan ^[1]; Abraham, Alyson ^[2]; Catalano, Demetra ^[3]; Younes, Ali ^[1]; Cutler, Cathy S. ^[1]; Medvedev, Dmitri ^[1]

Brookhaven National Lab. (BNL), Upton, NY (United States). Collider-Accelerator Division, Medical Isotope Research & Production Lab.
Stony Brook Univ., Stony Brook, NY (United States). Chemistry Dept.
Stony Brook Univ., Stony Brook, NY (United States). Biochemistry Dept.

Actinium-225 (²²⁵Ac) can be produced from a Thorium-229/Radium-225 (²²⁹Th/²²⁵Ra) generator, from high/low energy proton irradiated natural Thorium or Radium-226 target. Titanium based ion exchanger were evaluated for purification of ²²⁵Ac. Poorly crystalline silicotitanate (PCST) ion exchanger had high selectivity for Ba, Ag and Th. ²²⁵Ac was received with trace amounts of ²²⁷Ac, ²²⁷Th and ²²³Ra, and the solution was used to evaluate the retention of the isotopes on PCST ion exchanger. Over 90% of the ²²⁵Ac was recovered from PCST, and the radiopurity was >99% (calculated based on ²²⁵Ac, ²²⁷Th, and ²²³Ra). The capacity of the PCST inorganic ion exchange for Barium and ²³²Th was determined to be 24.19 mg/mL for Barium and 5.05 mg/mL for Thorium. PCST ion exchanger could separate ²²⁵Ac from isotopes of Ra and Th, and the process represents an interesting one step separation that could be used in an ²²⁵Ac generator from ²²⁵Ra and/or ²²⁹Th. Capacity studies indicated PCST could be used to separate ²²⁵Ac produced on small ²²⁶Ra targets (0.3–1 g), but PCST did not have a high enough capacity for production scale Th targets (50–100 g).

View Accepted Manuscript (DOE)

Research Organization:: Brookhaven National Laboratory (BNL), Upton, NY (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Nuclear Physics (NP) (SC-26)

Grant/Contract Number:: SC0012704

OSTI ID:: 1547020

Report Number(s):: BNL--211944-2019-JAAM

Journal Information:: Scientific Reports, Journal Name: Scientific Reports Journal Issue: 1 Vol. 9; ISSN 2045-2322

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

References (20)

Evaluation of SynPhase Lanterns for capturing Ac-225 from bulk thorium Fitzsimmons, Jonathan; Torre, Bryna; Foley, Bryan Journal of Radioanalytical and Nuclear Chemistry, Vol. 318, Issue 1 https://doi.org/10.1007/s10967-018-5997-8	journal	July 2018
Production of actinium-225 for alpha particle mediated radioimmunotherapy Boll, Rose A.; Malkemus, Dairin; Mirzadeh, Saed Applied Radiation and Isotopes, Vol. 62, Issue 5 https://doi.org/10.1016/j.apradiso.2004.12.003	journal	May 2005
Selective separation of radium and actinium from bulk thorium target material on strong acid cation exchange resin from sulfate media McAlister, Daniel R.; Horwitz, E. Philip Applied Radiation and Isotopes, Vol. 140 https://doi.org/10.1016/j.apradiso.2018.06.008	journal	October 2018
Application of ion exchange and extraction chromatography to the separation of actinium from proton-irradiated thorium metal for analytical purposes Radchenko, V.; Engle, J. W.; Wilson, J. J. Journal of Chromatography A, Vol. 1380, p. 55-63 https://doi.org/10.1016/j.chroma.2014.12.045	journal	February 2015
Crystallization of Sodium Titanium Silicate with Sitinakite Topology: Evolution from the Sodium Nonatitanate Phase Medvedev, Dmitri G.; Tripathi, Akhilesh; Clearfield, Abraham Chemistry of Materials, Vol. 16, Issue 19 https://doi.org/10.1021/cm049479a	journal	September 2004
Syntheses, Crystal Structures, and Ion-Exchange Properties of Porous Titanosilicates, HM ₃ Ti ₄ O ₄ (SiO ₄ ) ₃ ·4H ₂ O (M = H ⁺ , K ⁺ , Cs ⁺ ), Structural Analogues of the Mineral Pharmacosiderite Behrens, Elizabeth A.; Poojary, Damodara M.; Clearfield, Abraham Chemistry of Materials, Vol. 8, Issue 6 https://doi.org/10.1021/cm950534c	journal	January 1996
Strontium and Actinide Separations from High Level Nuclear Waste Solutions Using Monosodium Titanate 1. Simulant Testing Hobbs, D. T.; Barnes, M. J.; Pulmano, R. L. Separation Science and Technology, Vol. 40, Issue 15 https://doi.org/10.1080/01496390500385129	journal	November 2005
Rates of Exchange of Cs ⁺ and Sr ²⁺ for Poorly Crystalline Sodium Titanium Silicate (CST) in Nuclear Waste Systems Clearfield, Abraham; Medvedev, Dmitry G.; Kerlegon, Steven Solvent Extraction and Ion Exchange, Vol. 30, Issue 3 https://doi.org/10.1080/07366299.2011.639256	journal	May 2012
Development of a production scale purification of Ge-68 from irradiated gallium metal Fitzsimmons, Jonathan M.; Mausner, Leonard Radiochimica Acta, Vol. 103, Issue 2 https://doi.org/10.1515/ract-2014-2306	journal	January 2015
Bismuth-213 and Actinium-225 – Generator Performance and Evolving Therapeutic Applications of Two Generator-Derived Alpha-Emitting Radioisotopes Morgenstern, Alfred; Bruchertseifer, Frank; Apostolidis, Christos Current Radiopharmaceuticals, Vol. 5, Issue 3 https://doi.org/10.2174/1874471011205030221	journal	June 2012
Defining Processing Times for Accelerator Produced 225Ac and Other Isotopes from Proton Irradiated Thorium Fitzsimmons, Jonathan; Griswold, Justin; Medvedev, Dmitri Molecules, Vol. 24, Issue 6 https://doi.org/10.3390/molecules24061095	journal	March 2019
213Bi-DOTATOC receptor-targeted alpha-radionuclide therapy induces remission in neuroendocrine tumours refractory to beta radiation: a first-in-human experience Kratochwil, C.; Giesel, F. L.; Bruchertseifer, F. European Journal of Nuclear Medicine and Molecular Imaging, Vol. 41, Issue 11 https://doi.org/10.1007/s00259-014-2857-9	journal	July 2014
Titanium silicates, M3HTi4O4(SiO4)3·4H2O (M=Na+, K+),with three-dimensional tunnel structures for the selective removal of strontium and cesium from wastewater solutions Behrens, Elizabeth A.; Clearfield, Abraham Microporous Materials, Vol. 11, Issue 1-2 https://doi.org/10.1016/S0927-6513(97)00022-9	journal	August 1997
Cyclotron production of Ac-225 for targeted alpha therapy11Dedicated to Prof. Dr. Franz Baumgärtner on the occasion of his 75th birthday. Apostolidis, C.; Molinet, R.; McGinley, J. Applied Radiation and Isotopes, Vol. 62, Issue 3 https://doi.org/10.1016/j.apradiso.2004.06.013	journal	March 2005
Development of a large scale production of 67Cu from 68Zn at the high energy proton accelerator: Closing the 68Zn cycle Medvedev, Dmitri G.; Mausner, Leonard F.; Meinken, George E. Applied Radiation and Isotopes, Vol. 70, Issue 3 https://doi.org/10.1016/j.apradiso.2011.10.007	journal	March 2012
Assessment of a Sodium Nonatitanate and Pharmacosiderite-Type Ion Exchangers for Strontium and Cesium Removal from DOE Waste Simulants Behrens, Elizabeth A.; Sylvester, Paul; Clearfield, Abraham Environmental Science & Technology, Vol. 32, Issue 1 https://doi.org/10.1021/es9704794	journal	January 1998
Specific activity and isotope abundances of strontium in purified strontium-82 Fitzsimmons, J. M.; Medvedev, D. G.; Mausner, L. F. Journal of Analytical Atomic Spectrometry, Vol. 31, Issue 2 https://doi.org/10.1039/C5JA00419E	journal	January 2016
The Radiochemistry of Thorium Hyde, E. K. https://doi.org/10.2172/4241632	report	April 1959
Development and Properties of Crystalline Silicotitanate (CST) Ion Exchangers for Radioactive Waste Applications Miller, James E.; Brown, Norman E. https://doi.org/10.2172/469131	report	March 1997
New Approaches to Molecular Imaging of Multiple Myeloma Vij, R.; Fowler, K. J.; Shokeen, M. Journal of Nuclear Medicine, Vol. 57, Issue 1 https://doi.org/10.2967/jnumed.115.163808	journal	November 2015

Cited By (2)

Metal Oxide Sorbents for the Separation of Radium and Actinium Brown, M. Alex Industrial & Engineering Chemistry Research, Vol. 59, Issue 46 https://doi.org/10.1021/acs.iecr.0c04084	journal	November 2020
Guest Edited Collection: Radioisotopes and radiochemistry in health science Fassbender, Michael E. Scientific Reports, Vol. 10, Issue 1 https://doi.org/10.1038/s41598-019-56278-1	journal	January 2020

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43 PARTICLE ACCELERATORS
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