Lipid composition of liver microsomes and mitochondria after acute and chronic {gamma}-irradiation of rats
Journal Article
·
· Biochemistry (New York)
OSTI ID:28959
- Institute of Cell Biophysics, Moscow (Russian Federation)
Acute {gamma}-irradiation of rats at doses of 100 and 270 Gy stimulates lipid synthesis and changes the lipid composition of liver cell organelles. The content of cholesterol and cholesterol esters in microsomes increased at 100 Gy and decreased at 270 Gy, with total phospholipid content remaining unchanged. The lipid content in mitochondria decreased considerably 1 h after irradiation at 270 Gy. This change was significantly less pronounced 47 h later. Under chronic {gamma}-irradiation (0.129 Gy/day), cholesterol and cardiolipin in mitochondria increased. The changes in lipid content caused by acute irradiation are presumed to be related to activated synthesis of lipids in the liver. The modification of the lipid content of mitochondria observed in chronically irradiated rats may indicate that energy-metabolizing liver cell systems are involved in the adaptation to irradiation.
- OSTI ID:
- 28959
- Journal Information:
- Biochemistry (New York), Journal Name: Biochemistry (New York) Journal Issue: 7 Vol. 59; ISSN 0006-2979; ISSN BIORAK
- Country of Publication:
- United States
- Language:
- English
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