Soft tissue tumors in beagles injected with {sup 241}Am citrate
- Univ. of Utah, Salt Lake City, UT (United States); and others
The occurrence of soft tissue tumors has been studied in 117 beagles assigned to 8 dosage groups of between 2 and 26 animals each and injected with 0.07 to 104 kBq {sup 241}Am kg{sup -1} as the citrate. In addition, 133 control beagles given no radioactivity were used as a comparison group. All 250 dogs were maintained under identical conditions and were observed for their entire lifespans. An important competing risk for the appearance of soft tissue tumors appeared to be the occurrence of skeletal malignancy, and at the highest injected activity (104) kBq kg{sup -1}, kidney and liver failure brought about the death of both of the two dogs in this group. Thyroid and liver were the only soft tissues that exhibited greater concentrations of {sup 241}Am than the skeleton. Liver tumors were associated {sup 241}Am exposure (p < 0.001), but the thyroid tumor rate was not increased significantly in the irradiated animals (p > 0.10) as compared with the occurrence in controls. There was a greater relative occurrence of all vaginal tumors in control animals than in dogs given {sup 241}Am, a situation also found for all tumors of the pancreas, skin, testis, and mammary glands and for malignant ovarian tumors. All of these differences were statistically significant. The survival of animals given 0.07 to 0.59 kBq {sup 241}Am Kg{sup -1} could not be established (p > 0.10) as significantly different from controls, but the survival of all groups given 1.8 to 104 kBq kg{sup -1} was decreased (p < 0.05). There was no indication in our studies of a positive association between relative exposure to {sup 241}Am and the occurrence of mammary tumors, mast cell sarcomas originating outside the liver, lymphosarcoma or tumors of marrow, including leukemia. 20 refs., 1 fig., 8 tabs.
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC02-76EV00119
- OSTI ID:
- 285081
- Journal Information:
- Health Physics, Journal Name: Health Physics Journal Issue: 2 Vol. 68; ISSN HLTPAO; ISSN 0017-9078
- Country of Publication:
- United States
- Language:
- English
Similar Records
Soft-tissue tumors among beagles injected with {sup 226}Ra
Soft tissue tumors induced by monomeric {sup 239}Pu