Soft tissue tumors induced by monomeric {sup 239}Pu

Journal Article · Sun Oct 01 04:00:00 EDT 1995 · Health Physics

DOI:https://doi.org/10.1097/00004032-199510000-00012· OSTI ID:258835

Lloyd, R D; Angus, W; Taylor, G N; Miller, S C ^[1]

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1. Univ. of Utah School of Medicine, Salt Lake City, UT (United States); and others

Individual records of soft tissue tumor occurrence (lifetime incidence) among 236 beagles injected with {sup 239}Pu citrate as young adults and 131 comparable control beagles given no radioactivity enabled us to analyze the possible effects on soft tissue tumor induction resulting from internal exposure to {sup 239}Pu. A significant trend was identified in the proportion of animals having malignant liver tumors with increasing radiation dose from {sup 239}. There was also a significant difference in the relative numbers of both malignant liver tumors (18.1 expected, 66 observed). Malignant tumors of the mouth, pancreas, and skin were more frequent among controls than among the dogs given {sup 239}Pu as well as tumors (malignant plus benign) of the mouth, pancreas, testis, and vagina. For all other tumor sites or types, there was no significant difference for both malignant and all (malignant plus benign) tumors. Mammary tumor occurrence appeared not to be associated with {sup 239}Pu incorporation. We conclude that the only soft-tissue neoplasia induced by the intake of {sup 239}Pu directly into blood is probably a liver tumor. 20 refs., 6 tabs.

• Sponsoring Organization: USDOE
• DOE Contract Number: AC02-76EV00119; AC04-76EV01013
• OSTI ID: 258835
• Journal Information: Health Physics, Journal Name: Health Physics Journal Issue: 4 Vol. 69; ISSN HLTPAO; ISSN 0017-9078
• Country of Publication: United States
• Language: English

Related Subjects

56 BIOLOGY AND MEDICINE
APPLIED STUDIES
ANIMAL TISSUES
BEAGLES
BIOLOGICAL RADIATION EFFECTS
INJECTION
LIVER
NEOPLASMS
PANCREAS
PLUTONIUM 239
SKIN