Soft-tissue tumors among beagles injected with {sup 226}Ra

Journal Article · Tue Mar 01 04:00:00 EST 1994 · Health Physics

DOI:https://doi.org/10.1097/00004032-199403000-00008· OSTI ID:249871

Lloyd, R D; Taylor, G N; Angus, W ^[1]

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1. Univ. of Utah, Salt Lake City, UT (United States); and others

A total of 409 primary soft-tissue tumors (189 malignant) occurred among 87 of 120 young adult beagles (72.5%) injected with {sup 226}Ra in eight dose levels ranging from 0.2-440 kBq kg{sup -1} body mass, while a total of 565 primary soft-tissue tumors (208 of them malignant) were seen among 117 of 133 control beagles not given radioactivity (88%). Because the p-value for the difference in these two percentages was >0.05, further comparisons were not made of all tumor locations or types taken together but only of the individual tumor locations or types. There was a clear excess of malignant tumors and all tumors (benign plus malignant) in the eye among dogs injected with radium (p < 0.05, p < 0.01, respectively), but the occurrence of all the other types of soft-tissue tumors was not greater in irradiated vs. control dogs (p > 0.05). This was also true for hematopoietic tumor types (including just one leukemia in a control and none in irradiated dogs) in which there was no difference between controls and dogs given radium. 25 refs., 7 tabs.

• Sponsoring Organization: USDOE
• DOE Contract Number: AC02-76EV00119; AC04-76EV01013
• OSTI ID: 249871
• Journal Information: Health Physics, Journal Name: Health Physics Journal Issue: 3 Vol. 66; ISSN HLTPAO; ISSN 0017-9078
• Country of Publication: United States
• Language: English

Related Subjects

56 BIOLOGY AND MEDICINE
APPLIED STUDIES
BEAGLES
BIOLOGICAL RADIATION EFFECTS
EYES
INTRAVENOUS INJECTION
LEUKEMIA
NEOPLASMS
RADIUM 226