Characterization of the PSG11 gene
- Massey Univ., Palmerston North (New Zealand); and others
The pregnancy-specific {beta}{sub 1}-glycoproteins (PSG) form the major group of proteins synthesized in the human placenta. There are over 30 proteins in the family, encoded by 11 genes located on chromosome 19q13.1-13.3. The genes can be divided into three subgroups based on the C-terminal exons expressed. The subgroup 1 genes have been well characterized. In this study the organization and sequence of a complete, functional, subgroup 3 gene is described. It contains the C-terminal exons, C{sub w}, C{sub t}, and C{sub s}, which are expected from the transcripts characterized. Downstream from these exons are sequences homologous to the C-termini of the subgroup 1 type genes. This demonstrates that the subgroup 1, 2, and 3 genes are related via insertions/deletions. Comparison of the C-terminal sequences of the three subgroups of genes shows that the subgroup 2 and 3 genes are more closely related than, and are distinct from, the subgroup 1 genes. 38 refs., 3 figs.
- OSTI ID:
- 249992
- Journal Information:
- Genomics, Vol. 22, Issue 2; Other Information: PBD: 15 Jul 1994
- Country of Publication:
- United States
- Language:
- English
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