Peripheral Nerve Magnetoneurography With Optically Pumped Magnetometers

Bu, Yifeng; Prince, Jacob; Mojtahed, Hamed; Kimball, Donald; Shah, Vishal; Coleman, Todd; Sarkar, Mahasweta; Rao, Ramesh; Huang, Mingxiong; Schwindt, Peter; Borna, Amir; Lerman, Imanuel

doi:10.3389/fphys.2022.798376

Peripheral Nerve Magnetoneurography With Optically Pumped Magnetometers

Journal Article · Thu Mar 17 00:00:00 EDT 2022 · Frontiers in Physiology

DOI:https://doi.org/10.3389/fphys.2022.798376· OSTI ID:2471741

Bu, Yifeng ^[1]; Prince, Jacob ^[1]; Mojtahed, Hamed ^[1]; Kimball, Donald ^[1]; Shah, Vishal ^[2]; Coleman, Todd ^[3]; Sarkar, Mahasweta ^[4]; Rao, Ramesh ^[1]; Huang, Mingxiong ^[1]; Schwindt, Peter ^[5]; Borna, Amir ^[5]; Lerman, Imanuel ^[6]

University of California, San Diego, CA (United States)
QuSpin Inc., Boulder, CO (United States)
Stanford University, CA (United States)
San Diego State University, Stanford, CA (United States)
Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)
University of California, San Diego, CA (United States); VA, San Diego, CA (United States)

Electrodiagnosis is routinely integrated into clinical neurophysiology practice for peripheral nerve disease diagnoses, such as neuropathy, demyelinating disorders, nerve entrapment/impingement, plexopathy, or radiculopathy. Measured with conventional surface electrodes, the propagation of peripheral nerve action potentials along a nerve is the result of ionic current flow which, according to Ampere’s Law, generates a small magnetic field that is also detected as an “action current” by magnetometers, such as superconducting quantum interference device (SQUID) Magnetoencephalography (MEG) systems. Optically pumped magnetometers (OPMs) are an emerging class of quantum magnetic sensors with a demonstrated sensitivity at the 1 fT/√Hz level, capable of cortical action current detection. But OPMs were ostensibly constrained to low bandwidth therefore precluding their use in peripheral nerve electrodiagnosis. With careful OPM bandwidth characterization, we hypothesized OPMs may also detect compound action current signatures consistent with both Sensory Nerve Action Potential (SNAP) and the Hoffmann Reflex (H-Reflex). In as much, our work confirms OPMs enabled with expanded bandwidth can detect the magnetic signature of both the SNAP and H-Reflex. Taken together, OPMs now show potential as an emerging electrodiagnostic tool.

View Accepted Manuscript (DOE)

Research Organization:: Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)

Sponsoring Organization:: USDOE National Nuclear Security Administration (NNSA); Biological Advanced Research and Development Authority (BARDA)

Grant/Contract Number:: NA0003525

OSTI ID:: 2471741

Journal Information:: Frontiers in Physiology, Journal Name: Frontiers in Physiology Vol. 13; ISSN 1664-042X

Publisher:: Frontiers Media S.A.Copyright Statement

Country of Publication:: United States

Language:: English

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60 APPLIED LIFE SCIENCES
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super conducting quantum interference devices
Η-Reflex

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