Non-Invasive Functional-Brain-Imaging with an OPM-based Magnetoencephalography System

Borna, Amir; Carter, Tony R.; Colombo, Anthony P.; Jau, Yuan-Yu; McKay, Jim; Weisend, Michael; Taulu, Samu; Stephen, Julia M.; Schwindt, Peter D.  D.

doi:10.1371/journal.pone.0227684

Non-Invasive Functional-Brain-Imaging with an OPM-based Magnetoencephalography System

Journal Article · Thu Jan 23 23:00:00 EST 2020 · PLoS ONE

DOI:https://doi.org/10.1371/journal.pone.0227684· OSTI ID:1628983

^[1]; Carter, Tony R. ^[2]; Colombo, Anthony P. ^[2]; Jau, Yuan-Yu ^[2]; McKay, Jim ^[3]; Weisend, Michael ^[4]; Taulu, Samu ^[5]; Stephen, Julia M. ^[6]; Schwindt, Peter D. D. ^[2]

Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); DOE/OSTI
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Candoo Systems Inc., Coquitlam, BC (Canada)
StimScience, Inc., Berkeley, CA (United States)
Univ. of Washington, Seattle, WA (United States)
The Mind Research Network and Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (United States)

A non-invasive functional-brain-imaging system based on optically-pumped-magnetometers (OPM) is presented. The OPM-based magnetoencephalography (MEG) system features 20 OPM channels conforming to the subject’s scalp. We have conducted two MEG experiments on three subjects: assessment of somatosensory evoked magnetic field (SEF) and auditory evoked magnetic field (AEF) using our OPM-based MEG system and a commercial MEG system based on superconducting quantum interference devices (SQUIDs). We cross validated the robustness of our system by calculating the distance between the location of the equivalent current dipole (ECD) yielded by our OPM-based MEG system and the ECD location calculated by the commercial SQUID-based MEG system. We achieved sub-centimeter accuracy for both SEF and AEF responses in all three subjects. Due to the proximity (12 mm) of the OPM channels to the scalp, it is anticipated that future OPM-based MEG systems will offer enhanced spatial resolution as they will capture finer spatial features compared to traditional MEG systems employing SQUIDs.

View Accepted Manuscript (DOE)

Research Organization:: Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division

Grant/Contract Number:: NA0003525

OSTI ID:: 1628983

Journal Information:: PLoS ONE, Journal Name: PLoS ONE Journal Issue: 1 Vol. 15; ISSN 1932-6203

Publisher:: Public Library of ScienceCopyright Statement

Country of Publication:: United States

Language:: English

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