Experimental Senecavirus A Infection of Bovine Cell Lines and Colostrum-Deprived Calves

Buckley, Alexandra; Crawford, Lauren; Hoffman, Kyle; Falkenberg, Shollie

doi:10.3390/v14122809

Experimental Senecavirus A Infection of Bovine Cell Lines and Colostrum-Deprived Calves

Journal Article · Fri Dec 16 00:00:00 EST 2022 · Viruses

DOI:https://doi.org/10.3390/v14122809· OSTI ID:2471261

^[1]; Crawford, Lauren ^[1]; Hoffman, Kyle ^[1]; ^[1]

US Dept. of Agriculture (USDA), Ames, IA (United States). Agricultural Research Service (ARS)

Senecavirus A (SVA) is a causative agent for vesicular disease in swine, which is clinically indistinguishable from other vesicular diseases of swine including foot-and-mouth disease (FMD). Recently, it was reported that buffalo in Guangdong, China were experiencing clinical symptoms similar to FMD including mouth ulcers and lameness tested positive for SVA. The objective of this study was to determine the susceptibility of cattle (Bos taurus) to SVA infection. Initial in vitro work using the PrimeFlow assay demonstrated that bovine cell lines and peripheral blood mononuclear cells from cattle were susceptible to SVA infection. Subsequently, six colostrum-deprived Holstein calves were challenged with SVA intranasally. No vesicular lesions were observed after challenge. Serum, oral, nasal, and rectal swabs tested for SVA nucleic acid did not support significant viral replication and there was no evidence of seroconversion. Therefore, demonstrating cattle from this study were not susceptible to experimental SVA infection.

View Accepted Manuscript (DOE)

Research Organization:: Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: SC0014664

OSTI ID:: 2471261

Journal Information:: Viruses, Journal Name: Viruses Journal Issue: 12 Vol. 14; ISSN 1999-4915

Publisher:: MDPICopyright Statement

Country of Publication:: United States

Language:: English

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