Host genetics and gut microbiota composition: Baseline gut microbiota composition as a possible prognostic factor for the severity of COVID-19 in patients with familial Mediterranean fever disease

Tsaturyan, Vardan; Manvelyan, Anahit; Balayan, Marine; Harutyunyan, Natalya; Pepoyan, Elya; Torok, Tamas; Chikindas, Michael; Pepoyan, Astghik

doi:10.3389/fmicb.2023.1107485

Host genetics and gut microbiota composition: Baseline gut microbiota composition as a possible prognostic factor for the severity of COVID-19 in patients with familial Mediterranean fever disease

Journal Article · Thu Mar 30 00:00:00 EDT 2023 · Frontiers in Microbiology

DOI:https://doi.org/10.3389/fmicb.2023.1107485· OSTI ID:2470624

Tsaturyan, Vardan ^[1]; Manvelyan, Anahit ^[2]; Balayan, Marine ^[2]; Harutyunyan, Natalya ^[2]; Pepoyan, Elya ^[2]; Torok, Tamas ^[3]; Chikindas, Michael ^[4]; Pepoyan, Astghik ^[5]

Yerevan State Medical University (Armenia). International Association for Human and Animals Health Improvement
Yerevan State Medical University (Armenia). International Association for Human and Animals Health Improvement; Armenian National Agrarian University (Armenia)
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Rutgers Univ., New Brunswick, NJ (United States)
Yerevan State Medical University (Armenia). International Association for Human and Animals Health Improvement; Armenian National Agrarian University (Armenia); National Academy of Sciences (Armenia). International Scientific Educational Center

It is known that the gut microbiome of a healthy person affects the process of COVID-19 after getting infected with SARS-CoV-2 virus. It is also believed that colchicine can alleviate the severity of COVID-19. Current investigations aimed to evaluate the associations between the baseline gut microbiota composition of healthy and Familial Mediterranean fever (FMF) - carrier Armenian men populations, and the severity of the COVID-19 disease after their infection with the SARS-CoV-2. The study has a purpose of answering three core questions: i. Do the characteristics of gut microbiome of Armenians affect the course of COVID-19 severity? ii. How does the COVID-19 disease course on go for FMF patients who have been taking colchicine as a medication over the years after getting infected with SARS-CoV-2? iii. Is there an initial gut micribiota structure pattern for non-FMF and FMF patients in the cases when COVID-19 appears in mild form? The gut microbiota composition in non-FMF and FMF patients before the first infection (mild and moderate course of COVID-19) was considered. COVID-19 was diagnosed by SARS-CoV-2 nucleic acid RT-PCR in nasopharyngeal swab and/or sputum. The number of patients with male FMF with mild COVID-19 was approximately two times higher than that of non-FMF male subjects with COVID-19. In addition, an association of COVID-19 disease severity with the baseline gut Prevotella, Clostridium hiranonis, Eubacterium biforme, Veillonellaceae, Coprococcus, and Blautia diversities in the non-FMF and FMF populations were revealed by us, which can be used as risk/prognostic factor for the severity of COVID-19.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 2470624

Journal Information:: Frontiers in Microbiology, Journal Name: Frontiers in Microbiology Vol. 14; ISSN 1664-302X

Publisher:: Frontiers Research FoundationCopyright Statement

Country of Publication:: United States

Language:: English

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Host genetics and gut microbiota composition: Baseline gut microbiota composition as a possible prognostic factor for the severity of COVID-19 in patients with familial Mediterranean fever disease

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