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Probiotic Lactobacillus acidophilus Strain INMIA 9602 Er 317/402 Administration Reduces the Numbers of Candida albicans and Abundance of Enterobacteria in the Gut Microbiota of Familial Mediterranean Fever Patients

Journal Article · · Frontiers in Immunology
 [1];  [2];  [1];  [3];  [2];  [4];  [3];  [5];  [6];  [7]
  1. Armenian National Agrarian Univ., Yerevan (Armenia). Dept. of Food Safety and Biotechnology
  2. International Association for Human and Animals Health Improvement, Yerevan (Armenia)
  3. Yerevan State Medical Univ., Yerevan (Armenia)
  4. Armenian National Agrarian Univ., Yerevan (Armenia)
  5. Kyorin Univ., Tokyo (Japan). School of Medicine
  6. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
  7. Rutgers Univ., New Brunswick, NJ (United States). Health Promoting Naturals Lab. School of Environmental and Biological Sciences
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Intestinal microorganisms play a crucial role in health and disease. The disruption of host–microbiota homeostasis has been reported to occur not only during disease development but also as a result of medication. Familial Mediterranean fever (FMF) is an inflammatory genetic disease characterized by elevated systemic reactivity against the commensal gut microbiota and high levels of Candida albicans in the gut. This study’s major objective was to investigate the effects of commercial probiotic Narine on the relative abundance of gut bacteria (specifically, enterobacteria, lactobacilli, Staphylococcus aureus, and enterococci) of C. albicans carrier and non-carrier FMF patients in remission. Our main finding indicates that the probiotic reduces numbers of C. albicans and abundance of enterobacteria in male and female patients of C. albicans carriers and non-carriers. It has pivotal effect on Enterococcus faecalis: increase in male non-carriers and decrease in female ones regardless of C. albicans status. No effect was seen for Lactobacillus and S. aureus. Our data suggest that M694V/V726A pyrin inflammasome mutations leading to FMF disease may contribute to gender-specific differences in microbial community structure in FMF patients. The study’s secondary objective was to elucidate the gender-specific differences in the gut’s microbial community of FMF patients. The tendency was detected for higher counts of enterobacteria in female FMF subjects. However, the small number of patients of these groups preclude from conclusive statements, pointing at the need for additional investigations with appropriate for statistical analysis groups of subjects involved in the study.
Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Organization:
International Science and Technology Center (ISTC); USDOE National Nuclear Security Administration (NNSA), Office of Defense Nuclear Nonproliferation (NA-20)
Grant/Contract Number:
AC02-05CH11231
OSTI ID:
1489661
Journal Information:
Frontiers in Immunology, Journal Name: Frontiers in Immunology Vol. 9; ISSN 1664-3224
Publisher:
Frontiers Research FoundationCopyright Statement
Country of Publication:
United States
Language:
English

References (43)

A Yersinia Effector Protein Promotes Virulence by Preventing Inflammasome Recognition of the Type III Secretion System journal May 2010
Estrogen decreases tight junction protein ZO-1 expression in human primary gut tissues journal October 2017
Gender differences in autoimmune disease journal August 2014
Impaired immune and acute-phase responses in interleukin-6-deficient mice journal March 1994
The regulation of MEFV expression and its role in health and familial Mediterranean fever journal July 2011
Integrative inflammasome activity in the regulation of intestinal mucosal immune responses journal December 2012
Inflammasomes and intestinal inflammation journal April 2017
Gout-associated uric acid crystals activate the NALP3 inflammasome journal January 2006
Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome journal March 2013
Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS journal June 2016
Modulation of Post-Antibiotic Bacterial Community Reassembly and Host Response by Candida albicans journal July 2013
Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death journal May 2014
Adaptive immune responses to Candida albicans infection journal January 2015
Triggers for Attacks in Familial Mediterranean Fever: Application of the Case-Crossover Design journal January 2012
Autosomal dominant familial Mediterranean fever in Northern European Caucasians associated with deletion of p.M694 residue—a case series and genetic exploration journal May 2016
Cross-kingdom interactions: Candida albicans and bacteria journal October 2009
Lactobacillus acidophilus INMIA 9602 Er-2 strain 317/402 probiotic regulates growth of commensal Escherichia coli in gut microbiota of familial Mediterranean fever disease subjects journal February 2017
Lethal tuberculosis in interleukin-6-deficient mutant mice. journal January 1997
Increased NLRP3-dependent interleukin 1β secretion in patients with familial Mediterranean fever: correlation with MEFV genotype journal March 2013
Candida albicans Commensalism and Pathogenicity Are Intertwined Traits Directed by a Tightly Knit Transcriptional Regulatory Circuit journal March 2013
Elevated Systemic Antibodies towards Commensal Gut Microbiota in Autoinflammatory Condition journal September 2008
Comparing Bacterial Community Composition between Healthy and White Plague-Like Disease States in Orbicella annularis Using PhyloChip™ G3 Microarrays journal November 2013
A Novel Role for the NLRC4 Inflammasome in Mucosal Defenses against the Fungal Pathogen Candida albicans journal December 2011
Colchicine Use in Children and Adolescents With Familial Mediterranean Fever: Literature Review and Consensus Statement journal January 2007
The Role of Probiotics and Prebiotics in Inducing Gut Immunity journal January 2013
Potential of IL-1, IL-18 and Inflammasome Inhibition for the Treatment of Inflammatory Skin Diseases journal May 2017
NLRC4 Inflammasome-Mediated Production of IL-1β Modulates Mucosal Immunity in the Lung against Gram-Negative Bacterial Infection journal April 2012
Approach to urinary tract infections journal January 2009
Candida albicans and Enterococcus faecalis in the gut : Synergy in commensalism? journal September 2013
Gender Specific Differences in the Immune Response to Infection journal March 2011
The factors considered as trigger for the attacks in patients with familial Mediterranean fever journal July 2012
The effects of hormones on sex differences in infection: from genes to behavior journal August 2000
Enterobacteriaceae Act in Concert with the Gut Microbiota to Induce Spontaneous and Maternally Transmitted Colitis journal September 2010
Fire and death: the pyrin domain joins the death-domain superfamily journal December 2004
Purification, characterisation and identification of acidocin LCHV, an antimicrobial peptide produced by Lactobacillus acidophilus n.v. Er 317/402 strain Narine journal March 2010
MEFV-Gene Analysis in Armenian Patients with Familial Mediterranean Fever: Diagnostic Value and Unfavorable Renal Prognosis of the M694V Homozygous Genotype—Genetic and Therapeutic Implications journal July 1999
Susceptibility to Experimental Candida albicans Urinary Tract Infection in the Rat journal May 1987
Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation journal March 2016
Lethal tuberculosis in interleukin-6-deficient mutant mice. journal January 1997
Sex Difference in Link between Interleukin-6 and Stress journal August 2007
Correlation between age and gender in Candida species infections of complete denture wearers: a retrospective analysis journal January 2016
journal
Inhibition of Cronobacter sakazakii by Lactobacillus acidophilus n.v. Er2 317/402 journal October 2016

Cited By (5)

Anticandidal Activities by Lactobacillus Species: An Update on Mechanisms of Action journal July 2021
Effects of Probiotic Lactobacillus acidophilus Strain INMIA 9602 Er 317/402 and Putative Probiotic Lactobacilli on DNA Damages in the Small Intestine of Wistar Rats In Vivo journal December 2018
Low-Dose Electron-Beam Irradiation for the Improvement of Biofilm Formation by Probiotic Lactobacilli journal June 2019
Combined use of eBeam irradiation and the potential probiotic Lactobacillus rhamnosus Vahe for control of foodborne pathogen Klebsiella pneumoniae journal November 2019
The piglet mycobiome during the weaning transition: a pilot study1 journal May 2019

Figures / Tables (6)

Table 1(p. 4)table Table 1
Figure 1(p. 5)figure Figure 1
Figure 2(p. 6)figure Figure 2
Figure 3(p. 7)figure Figure 3
Figure 4(p. 8)figure Figure 4
Figure 5(p. 10)figure Figure 5

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Related Subjects

59 BASIC BIOLOGICAL SCIENCES
60 APPLIED LIFE SCIENCES
Candida albicans
Enterobacteriaceae
Enteroccocus faecalis
Lactobacillus acidophilus INMIA 9602 Er 317/402
M694V/V726A mutations
familial Mediterranean fever
gender
gut microbiota