Placebo-resistant gut bacteria: Akkermansia muciniphila spp. and Familial Mediterranean fever disease

Pepoyan, Elya; Marotta, Francesco; Manvelyan, Anahit; Galstyan, Artak; Stepanyan, Lena; Grigoryan, Hasmik; Grigoryan, Liana; Mikayelyan, Mikayel; Balayan, Marine; Harutyunyan, Natalya; Mirzabekyan, Susanna; Tsaturyan, Vardan; Torok, Tamas; Pepoyan, Astghik

doi:10.3389/fcimb.2024.1336752

Placebo-resistant gut bacteria: Akkermansia muciniphila spp. and Familial Mediterranean fever disease

Journal Article · Wed Feb 21 23:00:00 EST 2024 · Frontiers in Cellular and Infection Microbiology

DOI:https://doi.org/10.3389/fcimb.2024.1336752· OSTI ID:2470730

Pepoyan, Elya ^[1]; Marotta, Francesco ^[2]; Manvelyan, Anahit ^[3]; Galstyan, Artak ^[4]; Stepanyan, Lena ^[3]; Grigoryan, Hasmik ^[3]; Grigoryan, Liana ^[5]; Mikayelyan, Mikayel ^[3]; Balayan, Marine ^[3]; Harutyunyan, Natalya ^[3]; Mirzabekyan, Susanna ^[3]; Tsaturyan, Vardan ^[6]; Torok, Tamas ^[7]; Pepoyan, Astghik ^[3]

Armenian National Agrarian University, Yerevan (Armenia); International Association for Human and Animals Health Improvement, Yerevan (Armenia); Yerevan State Medical University (Armenia)
ReGenera R&D International for Aging Intervention, Milan (Italy)
Armenian National Agrarian University, Yerevan (Armenia); International Association for Human and Animals Health Improvement, Yerevan (Armenia)
Yerevan State Medical University (Armenia)
Armenian National Agrarian University, Yerevan (Armenia)
International Association for Human and Animals Health Improvement, Yerevan (Armenia); Yerevan State Medical University (Armenia)
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Introduction: Despite numerous investigations into the impact of drugs/probiotics on the gut microbiota composition in Familial Mediterranean Fever (FMF) patients, the question as to whether there exists a significant bacterial diversity(ies) independent of the placebo effect that can be reliably considered in clinical and nutritional trials remains unresolved. Methods: This study represents the in augural analysis of the placebo’s influence on the gut microbiota of both healthy individuals and FMF afflicted men, utilizing previously collected data from PhyloChip™ DNA microarray experiments. A total of 15 healthy and 15 FMF male volunteers, aged 18 to 50, participated in this partially randomized placebo trial, which is accessible through the GEO Series accession number GSE111835. Results and Discussion: Key findings from current investigations include i. the anticipated divergence in gut bacteria resistance to placebo between healthy and FMF individuals, ii. the minor impact of placebo on gut bacterial diversities in healthy individuals, with Enterobacteriaceae diversities identified as placebo-resistant among “healthy” gut bacteria, and iii. the comprehensive influence of placebo on all bacterial phyla in the gut microbiome of FMF patients, extending to nearly all bacterial genera, except for the resilience of gut Akkermansia muciniphila spp. to placebo in FMF patients. This study underscores the susceptibility of Faecalibacterium, Blautia, and Clostridium genera to placebo. Consequently, this investigation holds significance for the proper design of placebo-controlled trials and establishes a foundation for further exploration of the gut-brain axis. Furthermore, it contributes valuable insights to discussions regarding proposals for probiotic therapies, particularly focusing on Faecalibacterium spp., Blautia spp., and Clostridium spp.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE; State Committee of Science, Armenia

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 2470730

Journal Information:: Frontiers in Cellular and Infection Microbiology, Journal Name: Frontiers in Cellular and Infection Microbiology Vol. 14; ISSN 2235-2988

Publisher:: Frontiers Research FoundationCopyright Statement

Country of Publication:: United States

Language:: English

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Journal Article · Thu Apr 03 00:00:00 EDT 2025 · Microbial Biotechnology (Online) · OSTI ID:2565634

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60 APPLIED LIFE SCIENCES
Akkermansia muciniphila
Blautia
Enterobacteriaceae spp.
Faecalibacterium
familial Mediterranean fever
immunology
male patients
microbiology
microbiome
placebo

Placebo-resistant gut bacteria: Akkermansia muciniphila spp. and Familial Mediterranean fever disease

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