Lassa Virus Replicon Particle Vaccine Protects Strain 13/N Guinea Pigs Against Challenge With Geographically and Genetically Diverse Viral Strains

Spengler, Jessica R.; Kainulainen, Markus H.; Welch, Stephen R.; Coleman-McCray, JoAnn D.; Harmon, Jessica R.; Condrey, Jillian A.; Scholte, Florine E. M.; Nichol, Stuart T.; Montgomery, Joel M.; Albariño, César G.; Spiropoulou, Christina F.

doi:10.1093/infdis/jiac028

Lassa Virus Replicon Particle Vaccine Protects Strain 13/N Guinea Pigs Against Challenge With Geographically and Genetically Diverse Viral Strains

Journal Article · Sun Jan 30 23:00:00 EST 2022 · Journal of Infectious Diseases

DOI:https://doi.org/10.1093/infdis/jiac028· OSTI ID:2425727

; Kainulainen, Markus H.; ; Coleman-McCray, JoAnn D.; Harmon, Jessica R.; Condrey, Jillian A.; Scholte, Florine E. M.; Nichol, Stuart T.; Montgomery, Joel M.; Albariño, César G.; Spiropoulou, Christina F.

Abstract

Lassa virus (LASV) causes mild to severe hemorrhagic fever disease in humans. Strain 13/N guinea pigs are highly susceptible to infection with LASV strain Josiah (clade IV), providing a critical model system for therapeutics and vaccine development. To develop additional models of disease, we detail the clinical course in guinea pigs infected with 5 geographically and genetically diverse LASV strains. Two of the developed models (LASV clades II and III) were then used to evaluate efficacy of a virus replicon particle vaccine against heterologous LASV challenge, demonstrating complete protection against clinical disease after a single vaccination dose.

Research Organization:: Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

DOE Contract Number:: SC0014664

OSTI ID:: 2425727

Journal Information:: Journal of Infectious Diseases, Journal Name: Journal of Infectious Diseases Journal Issue: 9 Vol. 226; ISSN 0022-1899

Publisher:: Infectious Diseases Society of America

Country of Publication:: United States

Language:: English

References (15)

International External Quality Assessment Study for Molecular Detection of Lassa Virus Nikisins, Sergejs; Rieger, Toni; Patel, Pranav PLOS Neglected Tropical Diseases, Vol. 9, Issue 5 https://doi.org/10.1371/journal.pntd.0003793	journal	May 2015
Genetic Diversity among Lassa Virus Strains Bowen, Michael D.; Rollin, Pierre E.; Ksiazek, Thomas G. Journal of Virology, Vol. 74, Issue 15 https://doi.org/10.1128/JVI.74.15.6992-7004.2000	journal	August 2000
T Cell-Dependence of Lassa Fever Pathogenesis Flatz, Lukas; Rieger, Toni; Merkler, Doron PLoS Pathogens, Vol. 6, Issue 3 https://doi.org/10.1371/journal.ppat.1000836	journal	March 2010
The S Genome Segment Is Sufficient to Maintain Pathogenicity in Intra-Clade Lassa Virus Reassortants in a Guinea Pig Model Welch, Stephen R.; Scholte, Florine E. M.; Albariño, César G. Frontiers in Cellular and Infection Microbiology, Vol. 8 https://doi.org/10.3389/fcimb.2018.00240	journal	July 2018
Use of a Scalable Replicon-Particle Vaccine to Protect Against Lethal Lassa Virus Infection in the Guinea Pig Model Kainulainen, Markus H.; Spengler, Jessica R.; Welch, Stephen R. The Journal of Infectious Diseases, Vol. 217, Issue 12 https://doi.org/10.1093/infdis/jiy123	journal	March 2018
Pathogenesis of Lassa virus infection in guinea pigs Jahrling, P. B.; Smith, S.; Hesse, R. A. Infection and Immunity, Vol. 37, Issue 2 https://doi.org/10.1128/iai.37.2.771-778.1982	journal	August 1982
New Lineage of Lassa Virus, Togo, 2016 Whitmer, Shannon L. M.; Strecker, Thomas; Cadar, Daniel Emerging Infectious Diseases, Vol. 24, Issue 3 https://doi.org/10.3201/eid2403.171905	journal	March 2018
Lassa virus circulating in Liberia: a retrospective genomic characterisation Wiley, Michael R.; Fakoli, Lawrence; Letizia, Andrew G. The Lancet Infectious Diseases, Vol. 19, Issue 12 https://doi.org/10.1016/S1473-3099(19)30486-4	journal	December 2019
Chimeric Mice with Competent Hematopoietic Immunity Reproduce Key Features of Severe Lassa Fever Oestereich, Lisa; Lüdtke, Anja; Ruibal, Paula PLOS Pathogens, Vol. 12, Issue 5 https://doi.org/10.1371/journal.ppat.1005656	journal	May 2016
A Recombinant Vesicular Stomatitis Virus-Based Lassa Fever Vaccine Protects Guinea Pigs and Macaques against Challenge with Geographically and Genetically Distinct Lassa Viruses Safronetz, David; Mire, Chad; Rosenke, Kyle PLOS Neglected Tropical Diseases, Vol. 9, Issue 4 https://doi.org/10.1371/journal.pntd.0003736	journal	April 2015
Endemic Lassa fever in Liberia. III. Characterization of Lassa virus isolates Jahrling, Peter B.; Frame, John D.; Smith, Sheilda B. Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 79, Issue 3 https://doi.org/10.1016/0035-9203(85)90386-4	journal	January 1985
Ribavirin for the treatment of Lassa fever: A systematic review and meta-analysis Eberhardt, Kirsten Alexandra; Mischlinger, Johannes; Jordan, Sabine International Journal of Infectious Diseases, Vol. 87 https://doi.org/10.1016/j.ijid.2019.07.015	journal	October 2019
Protection From Lethal Lassa Disease Can Be Achieved Both Before and After Virus Exposure by Administration of Single-Cycle Replicating Lassa Virus Replicon Particles Kainulainen, Markus H.; Spengler, Jessica R.; Welch, Stephen R. The Journal of Infectious Diseases, Vol. 220, Issue 8 https://doi.org/10.1093/infdis/jiz284	journal	June 2019
A ML29 reassortant virus protects guinea pigs against a distantly related Nigerian strain of Lassa virus and can provide sterilizing immunity Carrion, Ricardo; Patterson, Jean L.; Johnson, Curtis Vaccine, Vol. 25, Issue 20 https://doi.org/10.1016/j.vaccine.2007.02.038	journal	May 2007
ChAdOx1-vectored Lassa fever vaccine elicits a robust cellular and humoral immune response and protects guinea pigs against lethal Lassa virus challenge Fischer, Robert J.; Purushotham, Jyothi N.; van Doremalen, Neeltje npj Vaccines, Vol. 6, Issue 1 https://doi.org/10.1038/s41541-021-00291-x	journal	March 2021

Similar Records

Complex adenovirus-vectored vaccine protects guinea pigs from three strains of Marburg virus challenges

Journal Article · Sat Sep 30 00:00:00 EDT 2006 · Virology · OSTI ID:20850564

Delineating the mechanism of anti-Lassa virus GPC-A neutralizing antibodies

Journal Article · Tue May 24 00:00:00 EDT 2022 · Cell Reports · OSTI ID:1877197

Lassa virus protein–protein interactions as mediators of Lassa fever pathogenesis

Journal Article · Thu Feb 27 23:00:00 EST 2025 · Virology Journal · OSTI ID:2530823

Related Subjects

Immunology
Infectious Diseases
Microbiology

Lassa Virus Replicon Particle Vaccine Protects Strain 13/N Guinea Pigs Against Challenge With Geographically and Genetically Diverse Viral Strains

Citation Formats

References (15)

Similar Records

Related Subjects