Lassa virus protein–protein interactions as mediators of Lassa fever pathogenesis

Jan, Sharon; Phadke, Kruttika Suhas; Lam, Victor Loc; Branda, Steven S.; Johnson, Dylan M.

doi:10.1186/s12985-025-02669-y

Lassa virus protein–protein interactions as mediators of Lassa fever pathogenesis

Journal Article · Thu Feb 27 23:00:00 EST 2025 · Virology Journal

DOI:https://doi.org/10.1186/s12985-025-02669-y· OSTI ID:2530823

Jan, Sharon ^[1]; Phadke, Kruttika Suhas ^[1]; Lam, Victor Loc ^[1]; Branda, Steven S. ^[1]; Johnson, Dylan M. ^[1]

Sandia National Lab. (SNL-CA), Livermore, CA (United States)

Viral hemorrhagic Lassa fever (LF), caused by Lassa virus (LASV), is a significant public health concern endemic in West Africa with high morbidity and mortality rates, limited treatment options, and potential for international spread. Despite advances in interrogating its epidemiology and clinical manifestations, the molecular mechanisms driving pathogenesis of LASV and other arenaviruses remain incompletely understood. This review synthesizes current knowledge regarding the role of LASV host-virus interactions in mediating the pathogenesis of LF, with emphasis on interactions between viral and host proteins. Through investigation of these critical protein–protein interactions, we identify potential therapeutic targets and discuss their implications for development of medical countermeasures including antiviral drugs. This review provides an update in recent literature of significant LASV host-virus interactions important in informing the development of targeted therapies and improving clinical outcomes for LF patients. Knowledge gaps are highlighted as opportunities for future research efforts that would advance the field of LASV and arenavirus pathogenesis.

View Accepted Manuscript (DOE)

Research Organization:: Sandia National Laboratories (SNL-CA), Livermore, CA (United States)

Sponsoring Organization:: USDOE National Nuclear Security Administration (NNSA)

Grant/Contract Number:: NA0003525

OSTI ID:: 2530823

Report Number(s):: SAND--2025-02607J

Journal Information:: Virology Journal, Journal Name: Virology Journal Journal Issue: 1 Vol. 22; ISSN 1743-422X

Publisher:: BioMed CentralCopyright Statement

Country of Publication:: United States

Language:: English

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The Curious Case of Arenavirus Entry, and Its Inhibition Nunberg, Jack H.; York, Joanne Viruses, Vol. 4, Issue 1 https://doi.org/10.3390/v4010083	journal	January 2012
Arenavirus Evasion of Host Anti-Viral Responses Hayes, Melissa; Salvato, Maria Viruses, Vol. 4, Issue 10 https://doi.org/10.3390/v4102182	journal	October 2012
Advanced Vaccine Candidates for Lassa Fever Lukashevich, Igor Viruses, Vol. 4, Issue 11 https://doi.org/10.3390/v4112514	journal	October 2012
Multifunctional Nature of the Arenavirus RING Finger Protein Z Fehling, Sarah Katharina; Lennartz, Frank; Strecker, Thomas Viruses, Vol. 4, Issue 11 https://doi.org/10.3390/v4112973	journal	November 2012
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Kinetic Study of Platelets and Fibrinogen in Lassa Virus-Infected Monkeys and Early Pathologic Events in Mopeia Virus-Infected Monkeys Lange, James V.; Mitchell, Sheila W.; Evatt, Bruce L. The American Journal of Tropical Medicine and Hygiene, Vol. 34, Issue 5 https://doi.org/10.4269/ajtmh.1985.34.999	journal	September 1985

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60 APPLIED LIFE SCIENCES
Lassa fever pathogenesis
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Lassa virus protein–protein interactions as mediators of Lassa fever pathogenesis

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