Development of 225Ac Production from Low Isotopic Dilution 229Th

Camacaro, Jose F.; Dunckley, Christopher P.; Harman, S. Elizabeth; Fitzgerald, Hilary A.; Lakes, Andrew L.; Liao, Zuolei; Ludwig, Russell C.; McBride, Katie M.; Yalcintas Bethune, Ezgi; Younes, Ali; Chatterjee, Sayandev; Lilley, Laura M.

doi:10.1021/acsomega.3c01769

Development of ²²⁵Ac Production from Low Isotopic Dilution ²²⁹Th

Journal Article · Wed Sep 27 00:00:00 EDT 2023 · ACS Omega

DOI:https://doi.org/10.1021/acsomega.3c01769· OSTI ID:2424429

^[1]; Dunckley, Christopher P. ^[1]; Harman, S. Elizabeth ^[1]; Fitzgerald, Hilary A. ^[1]; Lakes, Andrew L. ^[1]; Liao, Zuolei ^[1]; Ludwig, Russell C. ^[1]; McBride, Katie M. ^[1]; Yalcintas Bethune, Ezgi ^[1]; Younes, Ali ^[1]; ^[1]; ^[1]

TerraPower LLC, Bellevue, WA (United States)

The promise of ²²⁵Ac targeted alpha therapies has been on the horizon for the last two decades. TerraPower Isotopes are uniquely suited to produce clinically relevant quantities of ²²⁵Ac through the decay of ²²⁹Th. Herein, a rapid processing scheme to isolate radionuclidic and radioisotopically pure ²²⁵Ac in good yield (98%) produced from ²²⁹Th that contains significant quantities of ²²⁸Th activity is described. The characterization of each step of the process is presented along with the detailed characterization of the resulting ²²⁵Ac isotopic starting material that will support the cancer research and development efforts.

View Accepted Manuscript (DOE)

Research Organization:: TerraPower LLC, Bellevue, WA (United States)

Sponsoring Organization:: USDOE

OSTI ID:: 2424429

Journal Information:: ACS Omega, Journal Name: ACS Omega Journal Issue: 42 Vol. 8; ISSN 2470-1343

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Chemistry
Equilibrium
Isotopes
Materials
Organic polymers
Radioactive decay