Perspective on Lignin Conversion Strategies That Enable Next Generation Biorefineries

Shrestha, Shilva; Goswami, Shubhasish; Banerjee, Deepanwita; Garcia, Valentina Elizabeth; Zhou, Elizabeth; Olmsted, Charles N.; Majumder, Erica L.‐W.; Kumar, Deepak; Awasthi, Deepika; Mukhopadhyay, Aindrila; Singer, Steven W.; Gladden, John Michael; Simmons, Blake A.; Choudhary, Hemant

doi:10.1002/cssc.202301460

Perspective on Lignin Conversion Strategies That Enable Next Generation Biorefineries

Journal Article · Fri Apr 26 00:00:00 EDT 2024 · ChemSusChem

DOI:https://doi.org/10.1002/cssc.202301460· OSTI ID:2345300

^[1]; ^[2]; ^[2]; ^[2]; Zhou, Elizabeth ^[3]; ^[4]; ^[4]; ^[5]; ^[2]; ^[2]; ^[2]; ^[6]; ^[2]; ^[6]

Joint BioEnergy Institute (JBEI), Emeryville, CA (United States); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States); Johns Hopkins Univ., Baltimore, MD (United States)
Joint BioEnergy Institute (JBEI), Emeryville, CA (United States); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Joint BioEnergy Institute (JBEI), Emeryville, CA (United States)
Univ. of Wisconsin, Madison, WI (United States)
State Univ. of New York (SUNY), Syracuse, NY (United States). College of Environmental Science and Forestry
Joint BioEnergy Institute (JBEI), Emeryville, CA (United States); Sandia National Lab. (SNL-CA), Livermore, CA (United States)

The valorization of lignin, a currently underutilized component of lignocellulosic biomass, has attracted attention to promote a stable and circular bioeconomy. Successful approaches including thermochemical, biological, and catalytic lignin depolymerization have been demonstrated, enabling opportunities for lignino-refineries and lignocellulosic biorefineries. Although significant progress in lignin valorization has been made, this review describes unexplored opportunities in chemical and biological routes for lignin depolymerization and thereby contributes to economically and environmentally sustainable lignin-utilizing biorefineries. This review also highlights the integration of chemical and biological lignin depolymerization and identifies research gaps while also recommending future directions for scaling processes to establish a lignino-chemical industry.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States); Sandia National Laboratories (SNL-CA), Livermore, CA (United States)

Sponsoring Organization:: USDOE Laboratory Directed Research and Development (LDRD) Program; USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: AC02-05CH11231; NA0003525

OSTI ID:: 2345300

Report Number(s):: SAND--2024-05586J

Journal Information:: ChemSusChem, Journal Name: ChemSusChem Journal Issue: 16 Vol. 17; ISSN 1864-5631

Publisher:: ChemPubSoc EuropeCopyright Statement

Country of Publication:: United States

Language:: English

References (205)

Bio-based polymers production in a kraft lignin biorefinery: techno-economic assessment: Bio-based polymer production in a kraft lignin biorefinery Dessbesell, Luana; Yuan, Zhongshun; Hamilton, Shawn Biofuels, Bioproducts and Biorefining, Vol. 12, Issue 2 https://doi.org/10.1002/bbb.1834	journal	November 2017
Techno‐economic and greenhouse gas analyses of lignin valorization to eugenol and phenolic products in integrated ethanol biorefineries Martinez‐Hernandez, Elias; Cui, Xinguang; Scown, Corinne D. Biofuels, Bioproducts and Biorefining, Vol. 13, Issue 4 https://doi.org/10.1002/bbb.1989	journal	March 2019
Techno‐economic comparative assessment of novel lignin depolymerization routes to bio‐based aromatics Vural Gursel, Iris; Dijkstra, Jan W.; Huijgen, Wouter J. J. Biofuels, Bioproducts and Biorefining, Vol. 13, Issue 4 https://doi.org/10.1002/bbb.1999	journal	April 2019
Study of lignin biotransformation byAspergillus fumigatus and white-rot fungi using14C-labeled and unlabeled kraft lignins Kadam, Kiran L.; Drew, Stephen W. Biotechnology and Bioengineering, Vol. 28, Issue 3 https://doi.org/10.1002/bit.260280313	journal	March 1986
Metabolic characterization of anaerobic fungi provides a path forward for bioprocessing of crude lignocellulose Henske, John K.; Wilken, St. Elmo; Solomon, Kevin V. Biotechnology and Bioengineering, Vol. 115, Issue 4 https://doi.org/10.1002/bit.26515	journal	January 2018
Consolidated bioprocessing of lignocellulosic biomass to lactic acid by a synthetic fungal-bacterial consortium Shahab, Robert L.; Luterbacher, Jeremy S.; Brethauer, Simone Biotechnology and Bioengineering, Vol. 115, Issue 5 https://doi.org/10.1002/bit.26541	journal	February 2018
Combined evolutionary engineering and genetic manipulation improve low pH tolerance and butanol production in a synthetic microbial Clostridium community Wen, Zhiqiang; Ledesma‐Amaro, Rodrigo; Lu, Minrui Biotechnology and Bioengineering, Vol. 117, Issue 7 https://doi.org/10.1002/bit.27333	journal	April 2020
Developing Rhodococcus opacus and Sphingobium sp. coculture systems for valorization of lignin‐derived dimers Cai, Chenggu; Xu, Zhaoxian; Li, Jie Biotechnology and Bioengineering, Vol. 119, Issue 11 https://doi.org/10.1002/bit.28215	journal	September 2022
Lignin degradation by microorganisms: A review Atiwesh, Ghada; Parrish, Christopher C.; Banoub, Joseph Biotechnology Progress, Vol. 38, Issue 2 https://doi.org/10.1002/btpr.3226	journal	December 2021
Enzymatic Oxidation of Lignin: Challenges and Barriers Toward Practical Applications Chan, Jou C.; Paice, Michael; Zhang, Xiao ChemCatChem, Vol. 12, Issue 2 https://doi.org/10.1002/cctc.201901480	journal	November 2019
Funneled Depolymerization of Ionic Liquid‐Based Biorefinery “Heterogeneous” Lignin into Guaiacols over Reusable Palladium Catalyst Choudhary, Hemant; Das, Lalitendu; Pelton, Jeffrey G. Chemistry – A European Journal, Vol. 29, Issue 27 https://doi.org/10.1002/chem.202300330	journal	March 2023
From Lignin to Chemicals: An Expedition from Classical to Modern Catalytic Valorization Technologies Al‐Naji, Majd; Brandi, Francesco; Drieß, Matthias Chemie Ingenieur Technik, Vol. 94, Issue 11 https://doi.org/10.1002/cite.202200079	journal	October 2022
Front Cover: Chemoenzymatic Halocyclization of γ,δ‐Unsaturated Carboxylic Acids and Alcohols (ChemSusChem 1/2020) Younes, Sabry H. H.; Tieves, Florian; Lan, Dongming ChemSusChem, Vol. 13, Issue 1 https://doi.org/10.1002/cssc.201903373	journal	December 2019
Lignin Depolymerization: A Comparison of Methods to Analyze Monomers and Oligomers Bartolomei, Erika; Le Brech, Yann; Dufour, Anthony ChemSusChem, Vol. 13, Issue 17 https://doi.org/10.1002/cssc.202001126	journal	July 2020
Recent Advances in the Catalytic Depolymerization of Lignin towards Phenolic Chemicals: A Review Liu, Xudong; Bouxin, Florent P.; Fan, Jiajun ChemSusChem, Vol. 13, Issue 17 https://doi.org/10.1002/cssc.202001213	journal	August 2020
Isolation and test of novel yeast strains with lignin usage capability and phenolic compound resistance Bautista‐Guerrero, Anaid; Lara‐Diaz, Rene A.; Pihen, Valérie MicrobiologyOpen, Vol. 11, Issue 5 https://doi.org/10.1002/mbo3.1326	journal	October 2022
Development of new laccases by directed evolution: Functional and computational analyses Festa, Giovanna; Autore, Flavia; Fraternali, Franca Proteins: Structure, Function, and Bioinformatics, Vol. 72, Issue 1 https://doi.org/10.1002/prot.21889	journal	January 2008
Differential induction of enzymes involved in anaerobic metabolism of aromatic compounds in the denitrifying bacterium Thauera aromatica Heider, J.; Boll, Matthias; Breese, Klaus Archives of Microbiology, Vol. 170, Issue 2 https://doi.org/10.1007/s002030050623	journal	July 1998
Exploring the Lignin Catabolism Potential of Soil-Derived Lignocellulolytic Microbial Consortia by a Gene-Centric Metagenomic Approach Díaz-García, Laura; Bugg, Timothy D. H.; Jiménez, Diego Javier Microbial Ecology, Vol. 80, Issue 4 https://doi.org/10.1007/s00248-020-01546-1	journal	June 2020
Occurrence of lignin degradation genotypes and phenotypes among prokaryotes Tian, Jiang-Hao; Pourcher, Anne-Marie; Bouchez, Théodore Applied Microbiology and Biotechnology, Vol. 98, Issue 23 https://doi.org/10.1007/s00253-014-6142-4	journal	October 2014
Mapping the diversity of microbial lignin catabolism: experiences from the eLignin database Brink, Daniel P.; Ravi, Krithika; Lidén, Gunnar Applied Microbiology and Biotechnology, Vol. 103, Issue 10 https://doi.org/10.1007/s00253-019-09692-4	journal	April 2019
Characterization of Lignocellulolytic Enzymes from White-Rot Fungi Manavalan, Tamilvendan; Manavalan, Arulmani; Heese, Klaus Current Microbiology, Vol. 70, Issue 4 https://doi.org/10.1007/s00284-014-0743-0	journal	December 2014
Lignocellulose degrading extremozymes produced by Pichia pastoris: current status and future prospects Gündüz Ergün, Burcu; Çalık, Pınar Bioprocess and Biosystems Engineering, Vol. 39, Issue 1 https://doi.org/10.1007/s00449-015-1476-6	journal	October 2015
Identification of oleaginous yeasts that metabolize aromatic compounds Yaguchi, Allison; Franaszek, Nicole; O’Neill, Kaelyn Journal of Industrial Microbiology & Biotechnology, Vol. 47, Issue 9-10 https://doi.org/10.1007/s10295-020-02269-5	journal	March 2020
Co-cultured Production of Lignin-Modifying Enzymes with White-Rot Fungi Qi-he, Chen; Krügener, Sven; Hirth, Thomas Applied Biochemistry and Biotechnology, Vol. 165, Issue 2 https://doi.org/10.1007/s12010-011-9289-9	journal	June 2011
A Semi-Rational Approach to Engineering Laccase Enzymes Miele, Annalisa; Giardina, Paola; Notomista, Eugenio Molecular Biotechnology, Vol. 46, Issue 2 https://doi.org/10.1007/s12033-010-9289-y	journal	May 2010
Improved enzyme production on corncob hydrolysate by a xylose-evolved Pichia pastoris cell factory Bankefa, Olufemi Emmanuel; Samuel-Osamoka, Faith Charity; Oladeji, Seye Julius Journal of Food Science and Technology, Vol. 59, Issue 4 https://doi.org/10.1007/s13197-021-05135-z	journal	May 2021
Tandem catalytic approaches for lignin depolymerization: a review Kaur, Pritam; Singh, Gursharan; Arya, Shailendra Kumar Biomass Conversion and Biorefinery https://doi.org/10.1007/s13399-022-02980-6	journal	June 2022
Chemicals From Lignin Luo, Hao; Abu-Omar, Mahdi M. Encyclopedia of Sustainable Technologies https://doi.org/10.1016/B978-0-12-409548-9.10235-0	book	January 2017
Role of thermophilic cellulases and organisms in the conversion of biomass to biofuels Goswami, Shubhasish; Nath, Praveen; Datta, Supratim Extremozymes and Their Industrial Applications https://doi.org/10.1016/B978-0-323-90274-8.00010-1	book	June 2022
Molecular evidence for lignin degradation in sulfate-reducing mangrove sediments (Amazônia, Brazil) Dittmar, Thorsten; Lara, Rubén José Geochimica et Cosmochimica Acta, Vol. 65, Issue 9 https://doi.org/10.1016/S0016-7037(00)00619-0	journal	May 2001
Modifications of laccase activities of copper efflux oxidase, CueO by synergistic mutations in the first and second coordination spheres of the type I copper center Kataoka, Kunishige; Kogi, Hiroki; Tsujimura, Seiya Biochemical and Biophysical Research Communications, Vol. 431, Issue 3 https://doi.org/10.1016/j.bbrc.2013.01.040	journal	February 2013
Comparison of the growth of filamentous fungi and yeasts in lignocellulose-derived media Cavka, Adnan; Jo¨nsson, Leif J. Biocatalysis and Agricultural Biotechnology, Vol. 3, Issue 4 https://doi.org/10.1016/j.bcab.2014.04.003	journal	October 2014
Lignin degradation under anaerobic digestion: Influence of lignin modifications -A review Khan, Muhammad Usman; Ahring, Birgitte Kiaer Biomass and Bioenergy, Vol. 128 https://doi.org/10.1016/j.biombioe.2019.105325	journal	September 2019
Biological strategies for enhanced hydrolysis of lignocellulosic biomass during anaerobic digestion: Current status and future perspectives Shrestha, Shilva; Fonoll, Xavier; Khanal, Samir Kumar Bioresource Technology, Vol. 245 https://doi.org/10.1016/j.biortech.2017.08.089	journal	December 2017
Screening of a microbial consortium for selective degradation of lignin from tree trimmings Fang, Xiuxiu; Li, Qiumin; Lin, Yunqin Bioresource Technology, Vol. 254 https://doi.org/10.1016/j.biortech.2018.01.058	journal	April 2018
Lignin depolymerization and utilization by bacteria Xu, Rong; Zhang, Kai; Liu, Pu Bioresource Technology, Vol. 269 https://doi.org/10.1016/j.biortech.2018.08.118	journal	December 2018
Conversion of depolymerized sugars and aromatics from engineered feedstocks by two oleaginous red yeasts Rodriguez, Alberto; Ersig, Nadine; Geiselman, Gina M. Bioresource Technology, Vol. 286 https://doi.org/10.1016/j.biortech.2019.121365	journal	August 2019
Advances in lignin valorization towards bio-based chemicals and fuels: Lignin biorefinery Cao, Yang; Chen, Season S.; Zhang, Shicheng Bioresource Technology, Vol. 291 https://doi.org/10.1016/j.biortech.2019.121878	journal	November 2019
Biorefineries in circular bioeconomy: A comprehensive review Ubando, Aristotle T.; Felix, Charles B.; Chen, Wei-Hsin Bioresource Technology, Vol. 299 https://doi.org/10.1016/j.biortech.2019.122585	journal	March 2020
A field of dreams: Lignin valorization into chemicals, materials, fuels, and health-care products Becker, Judith; Wittmann, Christoph Biotechnology Advances, Vol. 37, Issue 6 https://doi.org/10.1016/j.biotechadv.2019.02.016	journal	November 2019
Review of advances in the development of laccases for the valorization of lignin to enable the production of lignocellulosic biofuels and bioproducts Leynaud Kieffer Curran, Laure M. C.; Pham, Le Thanh Mai; Sale, Kenneth L. Biotechnology Advances, Vol. 54 https://doi.org/10.1016/j.biotechadv.2021.107809	journal	January 2022
Polyhydroxyalkanoates synthesis by halophiles and thermophiles: towards sustainable production of microbial bioplastics Obruča, Stanislav; Dvořák, Pavel; Sedláček, Petr Biotechnology Advances, Vol. 58 https://doi.org/10.1016/j.biotechadv.2022.107906	journal	September 2022
Microbial lignin degradation in an industrial composting environment Duran, Katharina; van den Dikkenberg, Marijn; van Erven, Gijs Bioresource Technology Reports, Vol. 17 https://doi.org/10.1016/j.biteb.2021.100911	journal	February 2022
Reductive or oxidative catalytic lignin depolymerization: An overview of recent advances Bourbiaux, Dolorès; Pu, Junjie; Rataboul, Franck Catalysis Today, Vol. 373 https://doi.org/10.1016/j.cattod.2021.03.027	journal	August 2021
Design of computational retrobiosynthesis tools for the design of de novo synthetic pathways Hadadi, Noushin; Hatzimanikatis, Vassily Current Opinion in Chemical Biology, Vol. 28 https://doi.org/10.1016/j.cbpa.2015.06.025	journal	October 2015
Lignocellulose degradation mechanisms across the Tree of Life Cragg, Simon M.; Beckham, Gregg T.; Bruce, Neil C. Current Opinion in Chemical Biology, Vol. 29 https://doi.org/10.1016/j.cbpa.2015.10.018	journal	December 2015
Lignocellulose deconstruction in the biosphere Bomble, Yannick J.; Lin, Chien-Yuan; Amore, Antonella Current Opinion in Chemical Biology, Vol. 41 https://doi.org/10.1016/j.cbpa.2017.10.013	journal	December 2017
Tailoring microbes to upgrade lignin Davis, Kirsten; Moon, Tae Seok Current Opinion in Chemical Biology, Vol. 59 https://doi.org/10.1016/j.cbpa.2020.04.001	journal	December 2020
From models to lignin: Transition metal catalysis for selective bond cleavage reactions Deuss, Peter J.; Barta, Katalin Coordination Chemistry Reviews, Vol. 306 https://doi.org/10.1016/j.ccr.2015.02.004	journal	January 2016
Maximizing microbial bioproduction from sustainable carbon sources using iterative systems engineering Eng, Thomas; Banerjee, Deepanwita; Menasalvas, Javier Cell Reports, Vol. 42, Issue 9 https://doi.org/10.1016/j.celrep.2023.113087	journal	September 2023
Laboratory Evolution of High-Redox Potential Laccases Maté, Diana; García-Burgos, Carlos; García-Ruiz, Eva Chemistry & Biology, Vol. 17, Issue 9 https://doi.org/10.1016/j.chembiol.2010.07.010	journal	September 2010
Structure-based Engineering of a Plant-Fungal Hybrid Peroxidase for Enhanced Temperature and pH Tolerance Kohler, Amanda C.; Simmons, Blake A.; Sale, Kenneth L. Cell Chemical Biology, Vol. 25, Issue 8 https://doi.org/10.1016/j.chembiol.2018.04.014	journal	August 2018
A crucial review on polycyclic aromatic Hydrocarbons - Environmental occurrence and strategies for microbial degradation Premnath, N.; Mohanrasu, K.; Guru Raj Rao, R. Chemosphere, Vol. 280 https://doi.org/10.1016/j.chemosphere.2021.130608	journal	October 2021
Chemicals from lignin: Recent depolymerization techniques and upgrading extended pathways Wendisch, Volker F.; Kim, Younghwa; Lee, Jin-Ho Current Opinion in Green and Sustainable Chemistry, Vol. 14 https://doi.org/10.1016/j.cogsc.2018.05.006	journal	December 2018
Retrosynthetic design of metabolic pathways to chemicals not found in nature Lin, Geng-Min; Warden-Rothman, Robert; Voigt, Christopher A. Current Opinion in Systems Biology, Vol. 14 https://doi.org/10.1016/j.coisb.2019.04.004	journal	April 2019
Aerobic degradation of aromatic compounds Díaz, Eduardo; Jiménez, José Ignacio; Nogales, Juan Current Opinion in Biotechnology, Vol. 24, Issue 3 https://doi.org/10.1016/j.copbio.2012.10.010	journal	June 2013
Better together: engineering and application of microbial symbioses Hays, Stephanie G.; Patrick, William G.; Ziesack, Marika Current Opinion in Biotechnology, Vol. 36 https://doi.org/10.1016/j.copbio.2015.08.008	journal	December 2015
Opportunities and challenges in biological lignin valorization Beckham, Gregg T.; Johnson, Christopher W.; Karp, Eric M. Current Opinion in Biotechnology, Vol. 42 https://doi.org/10.1016/j.copbio.2016.02.030	journal	December 2016
Lignin structure and its engineering Ralph, John; Lapierre, Catherine; Boerjan, Wout Current Opinion in Biotechnology, Vol. 56 https://doi.org/10.1016/j.copbio.2019.02.019	journal	April 2019
Challenges and opportunities in biological funneling of heterogeneous and toxic substrates beyond lignin Borchert, Andrew J.; Henson, William R.; Beckham, Gregg T. Current Opinion in Biotechnology, Vol. 73 https://doi.org/10.1016/j.copbio.2021.06.007	journal	February 2022
Engineering microbial consortia with rationally designed cellular interactions Deter, Heather S.; Lu, Ting Current Opinion in Biotechnology, Vol. 76 https://doi.org/10.1016/j.copbio.2022.102730	journal	August 2022
Metabolic modelling approaches for describing and engineering microbial communities García-Jiménez, Beatriz; Torres-Bacete, Jesús; Nogales, Juan Computational and Structural Biotechnology Journal, Vol. 19 https://doi.org/10.1016/j.csbj.2020.12.003	journal	January 2021
A state-of-the-art review of biowaste biorefinery Ubando, Aristotle T.; Del Rosario, Aaron Jules R.; Chen, Wei-Hsin Environmental Pollution, Vol. 269 https://doi.org/10.1016/j.envpol.2020.116149	journal	January 2021
Protein engineering of Pseudomonas fluorescens peroxidase Dyp1B for oxidation of phenolic and polymeric lignin substrates Rahman Pour, Rahman; Ehibhatiomhan, Austine; Huang, Yuling Enzyme and Microbial Technology, Vol. 123 https://doi.org/10.1016/j.enzmictec.2019.01.002	journal	April 2019
Periplasmic expression of Pseudomonas fluorescens peroxidase Dyp1B and site-directed mutant Dyp1B enzymes enhances polymeric lignin degradation activity in Pseudomonas putida KT2440 Ehibhatiomhan, Austine O.; Pour, Rahman Rahman; Farnaud, Sebastien Enzyme and Microbial Technology, Vol. 162 https://doi.org/10.1016/j.enzmictec.2022.110147	journal	January 2023
A concise review of current lignin production, applications, products and their environmental impact Bajwa, D. S.; Pourhashem, G.; Ullah, A. H. Industrial Crops and Products, Vol. 139 https://doi.org/10.1016/j.indcrop.2019.111526	journal	November 2019
Recent advances in the exploitation and application of coculture systems for the bioconversion of lignocellulosic feedstocks Zou, Lihua; Jin, Xinzhu; Tao, Yuanming Industrial Crops and Products, Vol. 203 https://doi.org/10.1016/j.indcrop.2023.117117	journal	November 2023
Systems biology-guided understanding of white-rot fungi for biotechnological applications: A review Kijpornyongpan, Teeratas; Schwartz, Alexa; Yaguchi, Allison iScience, Vol. 25, Issue 7 https://doi.org/10.1016/j.isci.2022.104640	journal	July 2022
Characterization of a phylogenetically distinct extradiol dioxygenase involved in the bacterial catabolism of lignin-derived aromatic compounds Navas, Laura E.; Zahn, Michael; Bajwa, Harbir Journal of Biological Chemistry, Vol. 298, Issue 5 https://doi.org/10.1016/j.jbc.2022.101871	journal	May 2022
Syntrophic co-culture of Bacillus subtilis and Klebsiella pneumonia for degradation of kraft lignin discharged from rayon grade pulp industry Yadav, Sangeeta; Chandra, Ram Journal of Environmental Sciences, Vol. 33 https://doi.org/10.1016/j.jes.2015.01.018	journal	July 2015
Radical transfer but not heme distal residues is essential for pH dependence of dye-decolorizing activity of peroxidase from Vibrio cholerae Uchida, Takeshi; Omura, Issei; Umetsu, Sayaka Journal of Inorganic Biochemistry, Vol. 219 https://doi.org/10.1016/j.jinorgbio.2021.111422	journal	June 2021
Engineering Acinetobacter baylyi ADP1 for mevalonate production from lignin-derived aromatic compounds Arvay, Erika; Biggs, Bradley W.; Guerrero, Laura Metabolic Engineering Communications, Vol. 13 https://doi.org/10.1016/j.mec.2021.e00173	journal	December 2021
Development and characterization of a thermophilic, lignin degrading microbiota Ceballos, Shannon J.; Yu, Chaowei; Claypool, Josh T. Process Biochemistry, Vol. 63 https://doi.org/10.1016/j.procbio.2017.08.018	journal	December 2017
In-situ microaeration of anaerobic digester treating buffalo manure for enhanced biogas yield Zeb, Iftikhar; Yousaf, Sana; Ali, Muhammad Renewable Energy, Vol. 181 https://doi.org/10.1016/j.renene.2021.09.089	journal	January 2022
Identifying and creating pathways to improve biological lignin valorization Liu, Zhi-Hua; Le, Rosemary K.; Kosa, Matyas Renewable and Sustainable Energy Reviews, Vol. 105 https://doi.org/10.1016/j.rser.2019.02.009	journal	May 2019
Lignin utilization: A review of lignin depolymerization from various aspects Chio, Chonlong; Sain, Mohini; Qin, Wensheng Renewable and Sustainable Energy Reviews, Vol. 107 https://doi.org/10.1016/j.rser.2019.03.008	journal	June 2019
Recent progress in the thermal and catalytic conversion of lignin Ha, Jeong-Myeong; Hwang, Kyung-Ran; Kim, Young-Min Renewable and Sustainable Energy Reviews, Vol. 111 https://doi.org/10.1016/j.rser.2019.05.034	journal	September 2019
Recent progress and challenges in biological degradation and biotechnological valorization of lignin as an emerging source of bioenergy: A state-of-the-art review Park, Gwon Woo; Gong, Gyeongtaek; Joo, Jeong Chan Renewable and Sustainable Energy Reviews, Vol. 157 https://doi.org/10.1016/j.rser.2021.112025	journal	April 2022
Extremophiles and extremozymes in lignin bioprocessing Zhu, Daochen; Qaria, Majjid A.; Zhu, Bin Renewable and Sustainable Energy Reviews, Vol. 157 https://doi.org/10.1016/j.rser.2021.112069	journal	April 2022
A comprehensive insight into the application of white rot fungi and their lignocellulolytic enzymes in the removal of organic pollutants Zhuo, Rui; Fan, Fangfang Science of The Total Environment, Vol. 778 https://doi.org/10.1016/j.scitotenv.2021.146132	journal	July 2021
What makes Yarrowia lipolytica well suited for industry? Park, Young-Kyoung; Ledesma-Amaro, Rodrigo Trends in Biotechnology, Vol. 41, Issue 2 https://doi.org/10.1016/j.tibtech.2022.07.006	journal	February 2023
Creative biological lignin conversion routes toward lignin valorization Liu, Zhi-Hua; Li, Bing-Zhi; Yuan, Joshua S. Trends in Biotechnology, Vol. 40, Issue 12 https://doi.org/10.1016/j.tibtech.2022.09.014	journal	December 2022
Synthetic biology of extremophiles: a new wave of biomanufacturing Ye, Jian-Wen; Lin, Yi-Na; Yi, Xue-Qing Trends in Biotechnology, Vol. 41, Issue 3 https://doi.org/10.1016/j.tibtech.2022.11.010	journal	March 2023
Construction of stable microbial consortia for effective biochemical synthesis Jiang, Yujia; Wu, Ruofan; Zhang, Wenming Trends in Biotechnology, Vol. 41, Issue 11 https://doi.org/10.1016/j.tibtech.2023.05.008	journal	November 2023
Ecological Insights into the Dynamics of Plant Biomass-Degrading Microbial Consortia Jiménez, Diego Javier; Dini-Andreote, Francisco; DeAngelis, Kristen M. Trends in Microbiology, Vol. 25, Issue 10 https://doi.org/10.1016/j.tim.2017.05.012	journal	October 2017
Aromatic catabolic pathway selection for optimal production of pyruvate and lactate from lignin Johnson, Christopher W.; Beckham, Gregg T. Metabolic Engineering, Vol. 28 https://doi.org/10.1016/j.ymben.2015.01.005	journal	March 2015
RetroPath2.0: A retrosynthesis workflow for metabolic engineers Delépine, Baudoin; Duigou, Thomas; Carbonell, Pablo Metabolic Engineering, Vol. 45 https://doi.org/10.1016/j.ymben.2017.12.002	journal	January 2018
Design of mutualistic microbial consortia for stable conversion of carbon monoxide to value-added chemicals Cha, Sanghak; Lim, Hyun Gyu; Kwon, Seokmu Metabolic Engineering, Vol. 64 https://doi.org/10.1016/j.ymben.2021.02.001	journal	March 2021
Engineering Pseudomonas putida for efficient aromatic conversion to bioproduct using high throughput screening in a bioreactor Eng, Thomas; Banerjee, Deepanwita; Lau, Andrew K. Metabolic Engineering, Vol. 66 https://doi.org/10.1016/j.ymben.2021.04.015	journal	July 2021
Guiding stars to the field of dreams: Metabolically engineered pathways and microbial platforms for a sustainable lignin-based industry Weiland, Fabia; Kohlstedt, Michael; Wittmann, Christoph Metabolic Engineering, Vol. 71 https://doi.org/10.1016/j.ymben.2021.11.011	journal	May 2022
Bright Side of Lignin Depolymerization: Toward New Platform Chemicals Sun, Zhuohua; Fridrich, Bálint; de Santi, Alessandra Chemical Reviews, Vol. 118, Issue 2 https://doi.org/10.1021/acs.chemrev.7b00588	journal	January 2018
Cell Surface Display Fungal Laccase as a Renewable Biocatalyst for Degradation of Persistent Micropollutants Bisphenol A and Sulfamethoxazole Chen, Yingying; Stemple, Brooke; Kumar, Manish Environmental Science & Technology, Vol. 50, Issue 16 https://doi.org/10.1021/acs.est.6b01641	journal	July 2016
Engineering a Bacterial DyP-Type Peroxidase for Enhanced Oxidation of Lignin-Related Phenolics at Alkaline pH Brissos, Vânia; Tavares, Diogo; Sousa, Ana Catarina ACS Catalysis, Vol. 7, Issue 5 https://doi.org/10.1021/acscatal.6b03331	journal	April 2017
Conceptual Design of a Kraft Lignin Biorefinery for the Production of Valuable Chemicals via Oxidative Depolymerization Abdelaziz, Omar Y.; Al-Rabiah, Abdulrahman A.; El-Halwagi, Mahmoud M. ACS Sustainable Chemistry & Engineering, Vol. 8, Issue 23 https://doi.org/10.1021/acssuschemeng.0c02945	journal	June 2020
Termite Gut Microbiota Contribution to Wheat Straw Delignification in Anaerobic Bioreactors Dumond, Louison; Lam, Lydia Pui Ying; van Erven, Gijs ACS Sustainable Chemistry & Engineering, Vol. 9, Issue 5 https://doi.org/10.1021/acssuschemeng.0c07817	journal	January 2021
Can Multiple Ions in an Ionic Liquid Improve the Biomass Pretreatment Efficacy? Yao, Alexander; Choudhary, Hemant; Mohan, Mood ACS Sustainable Chemistry & Engineering, Vol. 9, Issue 12 https://doi.org/10.1021/acssuschemeng.0c09330	journal	March 2021
Engineering a Highly Thermostable High-Redox Potential Laccase Mateljak, Ivan; Alcalde, Miguel ACS Sustainable Chemistry & Engineering, Vol. 9, Issue 29 https://doi.org/10.1021/acssuschemeng.1c00622	journal	July 2021
Life Cycle Assessment of Catechols from Lignin Depolymerization Montazeri, Mahdokht; Eckelman, Matthew J. ACS Sustainable Chemistry & Engineering, Vol. 4, Issue 3 https://doi.org/10.1021/acssuschemeng.5b00550	journal	December 2015
Lipid Production from Dilute Alkali Corn Stover Lignin by Rhodococcus Strains He, Yucai; Li, Xiaolu; Ben, Haoxi ACS Sustainable Chemistry & Engineering, Vol. 5, Issue 3 https://doi.org/10.1021/acssuschemeng.6b02627	journal	January 2017
Approaches for More Efficient Biological Conversion of Lignocellulosic Feedstocks to Biofuels and Bioproducts Baral, Nawa Raj; Sundstrom, Eric R.; Das, Lalitendu ACS Sustainable Chemistry & Engineering, Vol. 7, Issue 10 https://doi.org/10.1021/acssuschemeng.9b01229	journal	April 2019
Computationally Prospecting Potential Pathways from Lignin Monomers and Dimers toward Aromatic Compounds Wang, Lin; Maranas, Costas D. ACS Synthetic Biology, Vol. 10, Issue 5 https://doi.org/10.1021/acssynbio.0c00598	journal	April 2021
Improved Manganese-Oxidizing Activity of DypB, a Peroxidase from a Lignolytic Bacterium Singh, Rahul; Grigg, Jason C.; Qin, Wei ACS Chemical Biology, Vol. 8, Issue 4 https://doi.org/10.1021/cb300608x	journal	January 2013
Role of Lignin in Reducing Life-Cycle Carbon Emissions, Water Use, and Cost for United States Cellulosic Biofuels Scown, Corinne D.; Gokhale, Amit A.; Willems, Paul A. Environmental Science & Technology, Vol. 48, Issue 15 https://doi.org/10.1021/es5012753	journal	July 2014
Lignins: Natural polymers from oxidative coupling of 4-hydroxyphenyl- propanoids Ralph, John; Lundquist, Knut; Brunow, Gösta Phytochemistry Reviews, Vol. 3, Issue 1-2, p. 29-60 https://doi.org/10.1023/B:PHYT.0000047809.65444.a4	journal	January 2004
A stabilized microbial ecosystem of self-limiting bacteria using synthetic quorum-regulated lysis Scott, Spencer R.; Din, M. Omar; Bittihn, Philip Nature Microbiology, Vol. 2, Issue 8 https://doi.org/10.1038/nmicrobiol.2017.83	journal	June 2017
Microbial degradation of aromatic compounds — from one strategy to four Fuchs, Georg; Boll, Matthias; Heider, Johann Nature Reviews Microbiology, Vol. 9, Issue 11, p. 803-816 https://doi.org/10.1038/nrmicro2652	journal	October 2011
Bacterial contributions to delignification and lignocellulose degradation in forest soils with metagenomic and quantitative stable isotope probing Wilhelm, Roland C.; Singh, Rahul; Eltis, Lindsay D. The ISME Journal, Vol. 13, Issue 2 https://doi.org/10.1038/s41396-018-0279-6	journal	September 2018
A promiscuous cytochrome P450 aromatic O-demethylase for lignin bioconversion Mallinson, Sam J. B.; Machovina, Melodie M.; Silveira, Rodrigo L. Nature Communications, Vol. 9, Issue 1 https://doi.org/10.1038/s41467-018-04878-2	journal	June 2018
Tools for engineering coordinated system behaviour in synthetic microbial consortia Kylilis, Nicolas; Tuza, Zoltan A.; Stan, Guy-Bart Nature Communications, Vol. 9, Issue 1 https://doi.org/10.1038/s41467-018-05046-2	journal	July 2018
Automated design of synthetic microbial communities Karkaria, Behzad D.; Fedorec, Alex J. H.; Barnes, Chris P. Nature Communications, Vol. 12, Issue 1 https://doi.org/10.1038/s41467-020-20756-2	journal	January 2021
Transforming biorefinery designs with ‘Plug-In Processes of Lignin’ to enable economic waste valorization Liu, Zhi-Hua; Hao, Naijia; Wang, Yun-Yan Nature Communications, Vol. 12, Issue 1 https://doi.org/10.1038/s41467-021-23920-4	journal	June 2021
Highly stable and tunable peptoid/hemin enzymatic mimetics with natural peroxidase-like activities Jian, Tengyue; Zhou, Yicheng; Wang, Peipei Nature Communications, Vol. 13, Issue 1 https://doi.org/10.1038/s41467-022-30285-9	journal	May 2022
Lignin deconstruction by anaerobic fungi Lankiewicz, Thomas S.; Choudhary, Hemant; Gao, Yu Nature Microbiology, Vol. 8, Issue 4 https://doi.org/10.1038/s41564-023-01336-8	journal	March 2023
Common principles and best practices for engineering microbiomes Lawson, Christopher E.; Harcombe, William R.; Hatzenpichler, Roland Nature Reviews Microbiology, Vol. 17, Issue 12 https://doi.org/10.1038/s41579-019-0255-9	journal	September 2019
Complex regulation in a Comamonas platform for diverse aromatic carbon metabolism Wilkes, Rebecca A.; Waldbauer, Jacob; Caroll, Austin Nature Chemical Biology, Vol. 19, Issue 5 https://doi.org/10.1038/s41589-022-01237-7	journal	February 2023
Genome-scale metabolic models of Microbacterium species isolated from a high altitude desert environment Mandakovic, Dinka; Cintolesi, Ángela; Maldonado, Jonathan Scientific Reports, Vol. 10, Issue 1 https://doi.org/10.1038/s41598-020-62130-8	journal	March 2020
RetroBioCat as a computer-aided synthesis planning tool for biocatalytic reactions and cascades Finnigan, William; Hepworth, Lorna J.; Flitsch, Sabine L. Nature Catalysis, Vol. 4, Issue 2 https://doi.org/10.1038/s41929-020-00556-z	journal	January 2021
Re-designing the substrate binding pocket of laccase for enhanced oxidation of sinapic acid Pardo, I.; Santiago, G.; Gentili, P. Catalysis Science & Technology, Vol. 6, Issue 11 https://doi.org/10.1039/C5CY01725D	journal	January 2016
Systems biology-guided biodesign of consolidated lignin conversion Lin, Lu; Cheng, Yanbing; Pu, Yunqiao Green Chemistry, Vol. 18, Issue 20 https://doi.org/10.1039/C6GC01131D	journal	January 2016
Chemicals from lignin: an interplay of lignocellulose fractionation, depolymerisation, and upgrading Schutyser, W.; Renders, T.; Van den Bosch, S. Chemical Society Reviews, Vol. 47, Issue 3 https://doi.org/10.1039/C7CS00566K	journal	January 2018
Life cycle assessment of adipic acid production from lignin Corona, Andrea; Biddy, Mary J.; Vardon, Derek R. Green Chemistry, Vol. 20, Issue 16 https://doi.org/10.1039/C8GC00868J	journal	January 2018
Bioprocess development for muconic acid production from aromatic compounds and lignin Salvachúa, Davinia; Johnson, Christopher W.; Singer, Christine A. Green Chemistry, Vol. 20, Issue 21 https://doi.org/10.1039/C8GC02519C	journal	January 2018
Funneling aromatic products of chemically depolymerized lignin into 2-pyrone-4-6-dicarboxylic acid with Novosphingobium aromaticivorans Perez, Jose M.; Kontur, Wayne S.; Alherech, Manar Green Chemistry, Vol. 21, Issue 6 https://doi.org/10.1039/C8GC03504K	journal	January 2019
Guidelines for performing lignin-first biorefining Abu-Omar, Mahdi M.; Barta, Katalin; Beckham, Gregg T. Energy & Environmental Science, Vol. 14, Issue 1 https://doi.org/10.1039/D0EE02870C	journal	January 2021
Compartmentalization of a synergistic fungal-bacterial consortium to boost lactic acid conversion from lignocellulose via consolidated bioprocessing Jiang, Yujia; Liu, Yansong; Yang, Xinyi Green Chemistry, Vol. 25, Issue 5 https://doi.org/10.1039/D2GC04520F	journal	January 2023
Directed evolution of a temperature-, peroxide- and alkaline pH-tolerant versatile peroxidase Garcia-Ruiz, Eva; Gonzalez-Perez, David; Ruiz-Dueñas, Francisco J. Biochemical Journal, Vol. 441, Issue 1 https://doi.org/10.1042/BJ20111199	journal	December 2011
Something old, something new: challenges and developments in Aspergillus niger biotechnology Cairns, Timothy C.; Barthel, Lars; Meyer, Vera Essays in Biochemistry, Vol. 65, Issue 2 https://doi.org/10.1042/EBC20200139	journal	July 2021
Data-assisted polymer retrosynthesis planning Chen, Lihua; Kern, Joseph; Lightstone, Jordan P. Applied Physics Reviews, Vol. 8, Issue 3 https://doi.org/10.1063/5.0052962	journal	September 2021
Design and characterization of synthetic fungal-bacterial consortia for direct production of isobutanol from cellulosic biomass Minty, Jeremy J.; Singer, Marc E.; Scholz, Scott A. Proceedings of the National Academy of Sciences, Vol. 110, Issue 36 https://doi.org/10.1073/pnas.1218447110	journal	August 2013
Lignin valorization through integrated biological funneling and chemical catalysis Linger, J. G.; Vardon, D. R.; Guarnieri, M. T. Proceedings of the National Academy of Sciences, Vol. 111, Issue 33, p. 12013-12018 https://doi.org/10.1073/pnas.1410657111	journal	August 2014
Characterization of alkylguaiacol-degrading cytochromes P450 for the biocatalytic valorization of lignin Fetherolf, Morgan M.; Levy-Booth, David J.; Navas, Laura E. Proceedings of the National Academy of Sciences, Vol. 117, Issue 41 https://doi.org/10.1073/pnas.1916349117	journal	September 2020
Intracellular pathways for lignin catabolism in white-rot fungi del Cerro, Carlos; Erickson, Erika; Dong, Tao Proceedings of the National Academy of Sciences, Vol. 118, Issue 9 https://doi.org/10.1073/pnas.2017381118	journal	February 2021
A heterodimeric glutathione S -transferase that stereospecifically breaks lignin's β( R )-aryl ether bond reveals the diversity of bacterial β-etherases Kontur, Wayne S.; Olmsted, Charles N.; Yusko, Larissa M. Journal of Biological Chemistry, Vol. 294, Issue 6 https://doi.org/10.1074/jbc.RA118.006548	journal	December 2018
The fate of lignin and lignin‐derived compounds in anaerobic environments Young, L. Y.; Frazer, A. C. Geomicrobiology Journal, Vol. 5, Issue 3-4 https://doi.org/10.1080/01490458709385973	journal	January 1987
Enhanced catalytic efficiency of CotA-laccase by DNA shuffling Ouyang, Fengju; Zhao, Min Bioengineered, Vol. 10, Issue 1 https://doi.org/10.1080/21655979.2019.1621134	journal	January 2019
Rethinking microbial infallibility in the metagenomics era O'Malley, Maureen A.; Walsh, David A. FEMS Microbiology Ecology, Vol. 97, Issue 8 https://doi.org/10.1093/femsec/fiab092	journal	June 2021
Comparative Genomics of Early-Diverging Mushroom-Forming Fungi Provides Insights into the Origins of Lignocellulose Decay Capabilities Nagy, László G.; Riley, Robert; Tritt, Andrew Molecular Biology and Evolution, Vol. 33, Issue 4 https://doi.org/10.1093/molbev/msv337	journal	December 2015
The IMG/M data management and analysis system v.7: content updates and new features Chen, I-Min A.; Chu, Ken; Palaniappan, Krishnaveni Nucleic Acids Research, Vol. 51, Issue D1 https://doi.org/10.1093/nar/gkac976	journal	November 2022
Identification of two mutations that cause defects in the ligninolytic system through an efficient forward genetics in the white‐rot agaricomycete P leurotus ostreatus Nakazawa, Takehito; Izuno, Ayako; Kodera, Rina Environmental Microbiology, Vol. 19, Issue 1 https://doi.org/10.1111/1462-2920.13595	journal	December 2016
The lignin‐degrading abilities of Gelatoporia subvermispora gat1 and pex1 mutants generated via CRISPR/Cas9 Nakazawa, Takehito; Inoue, Chikako; Morimoto, Ryota Environmental Microbiology, Vol. 25, Issue 8 https://doi.org/10.1111/1462-2920.16372	journal	March 2023
Bacterial catabolism of lignin-derived aromatics: New findings in a recent decade: Update on bacterial lignin catabolism: Bacterial catabolism of lignin-derived aromatics Kamimura, Naofumi; Takahashi, Kenji; Mori, Kosuke Environmental Microbiology Reports, Vol. 9, Issue 6 https://doi.org/10.1111/1758-2229.12597	journal	November 2017
Synthetic microbial consortia with programmable ecological interactions Li, Shuyao; Xiao, Jing; Sun, Tianzheng Methods in Ecology and Evolution, Vol. 13, Issue 7 https://doi.org/10.1111/2041-210X.13894	journal	May 2022
Biorefinery for combined production of jet fuel and ethanol from lipid-producing sugarcane: a techno-economic evaluation Kumar, Deepak; Long, Stephen P.; Singh, Vijay GCB Bioenergy, Vol. 10, Issue 2 https://doi.org/10.1111/gcbb.12478	journal	September 2017
Molecular basis for the biodegradative recalcitrance of lignin in anaerobic environments Zeikus, J. G.; Wellstein, A. L.; Kirk, T. K. FEMS Microbiology Letters, Vol. 15, Issue 3 https://doi.org/10.1111/j.1574-6968.1982.tb00066.x	journal	November 1982
Degradation of benzyl ether bonds of lignin by ruminal microbes Kajikawa, Hiroshi; Kudo, Hiroshi; Kondo, Tsuneo FEMS Microbiology Letters, Vol. 187, Issue 1 https://doi.org/10.1111/j.1574-6968.2000.tb09129.x	journal	June 2000
Aspergilli and lignocellulosics: Enzymology and biotechnological applications Cardoso Duarte, JosÃ©; Costa-Ferreira, Maria FEMS Microbiology Reviews, Vol. 13, Issue 2-3 https://doi.org/10.1111/j.1574-6976.1994.tb00057.x	journal	March 1994
Isolation of a laccase-coding gene from the lignin-degrading fungusPhlebia brevisporaBAFC 633 and heterologous expression inPichia pastoris Fonseca, M. I.; Molina, M. A.; Winnik, D. L. Journal of Applied Microbiology, Vol. 124, Issue 6 https://doi.org/10.1111/jam.13720	journal	March 2018
Lignin Valorization: Improving Lignin Processing in the Biorefinery Ragauskas, A. J.; Beckham, G. T.; Biddy, M. J. Science, Vol. 344, Issue 6185, p. 1246843-1246843 https://doi.org/10.1126/science.1246843	journal	May 2014
A heterogeneous microbial consortium producing short-chain fatty acids from lignocellulose Shahab, Robert L.; Brethauer, Simone; Davey, Matthew P. Science, Vol. 369, Issue 6507 https://doi.org/10.1126/science.abb1214	journal	August 2020
Dilution-to-Stimulation/Extinction Method: a Combination Enrichment Strategy To Develop a Minimal and Versatile Lignocellulolytic Bacterial Consortium Díaz-García, Laura; Huang, Sixing; Spröer, Cathrin Applied and Environmental Microbiology, Vol. 87, Issue 2 https://doi.org/10.1128/AEM.02427-20	journal	January 2021
Functional Expression of a Fungal Laccase in Saccharomyces cerevisiae by Directed Evolution Bulter, T.; Alcalde, M.; Sieber, V. Applied and Environmental Microbiology, Vol. 69, Issue 2 https://doi.org/10.1128/AEM.69.2.987-995.2003	journal	February 2003
PATRIC: the Comprehensive Bacterial Bioinformatics Resource with a Focus on Human Pathogenic Species Gillespie, Joseph J.; Wattam, Alice R.; Cammer, Stephen A. Infection and Immunity, Vol. 79, Issue 11 https://doi.org/10.1128/IAI.00207-11	journal	September 2011
Simultaneous carbon catabolite repression governs sugar and aromatic co-utilization in Pseudomonas putida M2 Shrestha, Shilva; Awasthi, Deepika; Chen, Yan Applied and Environmental Microbiology, Vol. 89, Issue 10 https://doi.org/10.1128/aem.00852-23	journal	October 2023
Degradation of Methoxylated Benzoic Acids by a Nocardia from a Lignin-Rich Environment: Significance to Lignin Degradation and Effect of Chloro Substituents Crawford, R. L.; McCoy, Elizabeth; Harkin, J. M. Applied Microbiology, Vol. 26, Issue 2 https://doi.org/10.1128/am.26.2.176-184.1973	journal	August 1973
Deconstruction of Lignocellulosic Biomass to Fuels and Chemicals Chundawat, Shishir P. S.; Beckham, Gregg T.; Himmel, Michael E. Annual Review of Chemical and Biomolecular Engineering, Vol. 2, Issue 1, p. 121-145 https://doi.org/10.1146/annurev-chembioeng-061010-114205	journal	July 2011
The genome of the white-rot fungus Pycnoporus cinnabarinus: a basidiomycete model with a versatile arsenal for lignocellulosic biomass breakdown Levasseur, Anthony; Lomascolo, Anne; Chabrol, Olivier BMC Genomics, Vol. 15, Issue 1 https://doi.org/10.1186/1471-2164-15-486	journal	January 2014
Engineering a fungal peroxidase that degrades lignin at very acidic pH Fernández-Fueyo, Elena; Ruiz-Dueñas, Francisco J.; Martínez, Angel T. Biotechnology for Biofuels, Vol. 7, Issue 1 https://doi.org/10.1186/1754-6834-7-114	journal	January 2014
Complete genome sequence of the lignin-degrading bacterium Klebsiella sp. strain BRL6-2 Woo, Hannah L.; Ballor, Nicholas R.; Hazen, Terry C. Standards in Genomic Sciences, Vol. 9, Issue 1 https://doi.org/10.1186/1944-3277-9-19	journal	January 2014
RetSynth: determining all optimal and sub-optimal synthetic pathways that facilitate synthesis of target compounds in chassis organisms Whitmore, Leanne S.; Nguyen, Bernard; Pinar, Ali BMC Bioinformatics, Vol. 20, Issue 1 https://doi.org/10.1186/s12859-019-3025-9	journal	September 2019
Neurospora discreta as a model to assess adaptation of soil fungi to warming Romero-Olivares, Adriana L.; Taylor, John W.; Treseder, Kathleen K. BMC Evolutionary Biology, Vol. 15, Issue 1 https://doi.org/10.1186/s12862-015-0482-2	journal	September 2015
Metabolic engineering of Corynebacterium glutamicum for the production of cis, cis-muconic acid from lignin Becker, Judith; Kuhl, Martin; Kohlstedt, Michael Microbial Cell Factories, Vol. 17, Issue 1 https://doi.org/10.1186/s12934-018-0963-2	journal	July 2018
Advanced one-pot deconstruction and valorization of lignocellulosic biomass into triacetic acid lactone using Rhodosporidium toruloides Otoupal, Peter B.; Geiselman, Gina M.; Oka, Asun M. Microbial Cell Factories, Vol. 21, Issue 1 https://doi.org/10.1186/s12934-022-01977-0	journal	December 2022
Transcriptomic analysis of lignocellulosic biomass degradation by the anaerobic fungal isolate Orpinomyces sp. strain C1A Couger, M. B.; Youssef, Noha H.; Struchtemeyer, Christopher G. Biotechnology for Biofuels, Vol. 8, Issue 1 https://doi.org/10.1186/s13068-015-0390-0	journal	December 2015
Rhodosporidium toruloides: a new platform organism for conversion of lignocellulose into terpene biofuels and bioproducts Yaegashi, Junko; Kirby, James; Ito, Masakazu Biotechnology for Biofuels, Vol. 10, Issue 1 https://doi.org/10.1186/s13068-017-0927-5	journal	October 2017
Combinatorial pretreatment and fermentation optimization enabled a record yield on lignin bioconversion Liu, Zhi-Hua; Xie, Shangxian; Lin, Furong Biotechnology for Biofuels, Vol. 11, Issue 1 https://doi.org/10.1186/s13068-018-1021-3	journal	January 2018
Lignolytic-consortium omics analyses reveal novel genomes and pathways involved in lignin modification and valorization Moraes, Eduardo C.; Alvarez, Thabata M.; Persinoti, Gabriela F. Biotechnology for Biofuels, Vol. 11, Issue 1 https://doi.org/10.1186/s13068-018-1073-4	journal	March 2018
In silico-designed lignin peroxidase from Phanerochaete chrysosporium shows enhanced acid stability for depolymerization of lignin Pham, Le Thanh Mai; Seo, Hogyun; Kim, Kyung-Jin Biotechnology for Biofuels, Vol. 11, Issue 1 https://doi.org/10.1186/s13068-018-1324-4	journal	December 2018
A thermostable bacterial lytic polysaccharide monooxygenase with high operational stability in a wide temperature range Tuveng, Tina Rise; Jensen, Marianne Slang; Fredriksen, Lasse Biotechnology for Biofuels, Vol. 13, Issue 1 https://doi.org/10.1186/s13068-020-01834-5	journal	November 2020
Depolymerization and conversion of lignin to value-added bioproducts by microbial and enzymatic catalysis Weng, Caihong; Peng, Xiaowei; Han, Yejun Biotechnology for Biofuels, Vol. 14, Issue 1 https://doi.org/10.1186/s13068-021-01934-w	journal	April 2021
Enhanced lignin biodegradation by consortium of white rot fungi: microbial synergistic effects and product mapping Cui, Tangwu; Yuan, Bo; Guo, Haiwei Biotechnology for Biofuels, Vol. 14, Issue 1 https://doi.org/10.1186/s13068-021-02011-y	journal	July 2021
Bottom-up synthetic ecology study of microbial consortia to enhance lignocellulose bioconversion Lin, Lu Biotechnology for Biofuels and Bioproducts, Vol. 15, Issue 1 https://doi.org/10.1186/s13068-022-02113-1	journal	February 2022
Degradation of lignin in different lignocellulosic biomass by steam explosion combined with microbial consortium treatment Zhang, Wen; Diao, Chenyang; Wang, Lei Biotechnology for Biofuels and Bioproducts, Vol. 16, Issue 1 https://doi.org/10.1186/s13068-023-02306-2	journal	March 2023
Bacterial transformation of lignin: key enzymes and high-value products Gu, Jinming; Qiu, Qing; Yu, Yue Biotechnology for Biofuels and Bioproducts, Vol. 17, Issue 1 https://doi.org/10.1186/s13068-023-02447-4	journal	January 2024
Cinnamic acid and p-coumaric acid are metabolized to 4-hydroxybenzoic acid by Yarrowia lipolytica Konzock, Oliver; Tous-Mohedano, Marta; Cibin, Irene AMB Express, Vol. 13, Issue 1 https://doi.org/10.1186/s13568-023-01590-3	journal	August 2023
Genome sequence and description of the anaerobic lignin-degrading bacterium Tolumonas lignolytica sp. nov. Billings, Andrew F.; Fortney, Julian L.; Hazen, Terry C. Standards in Genomic Sciences, Vol. 10, Issue 1 https://doi.org/10.1186/s40793-015-0100-3	journal	November 2015
Azoarcus sp. CIB, an Anaerobic Biodegrader of Aromatic Compounds Shows an Endophytic Lifestyle Fernández, Helga; Prandoni, Nicolás; Fernández-Pascual, Mercedes PLoS ONE, Vol. 9, Issue 10 https://doi.org/10.1371/journal.pone.0110771	journal	October 2014
A review of biological delignification and detoxification methods for lignocellulosic bioethanol production Moreno, Antonio D.; Ibarra, David; Alvira, Pablo Critical Reviews in Biotechnology, Vol. 35, Issue 3 https://doi.org/10.3109/07388551.2013.878896	journal	October 2013
Editorial: Bioprospecting and Biotechnology of Extremophiles Jorquera, Milko A.; Graether, Steffen P.; Maruyama, Fumito Frontiers in Bioengineering and Biotechnology, Vol. 7 https://doi.org/10.3389/fbioe.2019.00204	journal	August 2019
Bacterial Valorization of Lignin: Strains, Enzymes, Conversion Pathways, Biosensors, and Perspectives Lee, Siseon; Kang, Minsik; Bae, Jung-Hoon Frontiers in Bioengineering and Biotechnology, Vol. 7 https://doi.org/10.3389/fbioe.2019.00209	journal	September 2019
Multi-Omics Driven Metabolic Network Reconstruction and Analysis of Lignocellulosic Carbon Utilization in Rhodosporidium toruloides Kim, Joonhoon; Coradetti, Samuel T.; Kim, Young-Mo Frontiers in Bioengineering and Biotechnology, Vol. 8 https://doi.org/10.3389/fbioe.2020.612832	journal	January 2021
Improvement of the Stability and Activity of an LPMO Through Rational Disulfide Bonds Design Zhou, Xiaoli; Xu, Zhiqiang; Li, Yueqiu Frontiers in Bioengineering and Biotechnology, Vol. 9 https://doi.org/10.3389/fbioe.2021.815990	journal	January 2022
Industrial Biotechnology Based on Enzymes From Extreme Environments Mesbah, Noha M. Frontiers in Bioengineering and Biotechnology, Vol. 10 https://doi.org/10.3389/fbioe.2022.870083	journal	April 2022
Finding values in lignin: A promising yet under-utilized component of the lignocellulosic biomass Jassal, Vidhisha; Dou, Chang; Sun, Ning Frontiers in Chemical Engineering, Vol. 4 https://doi.org/10.3389/fceng.2022.1059305	journal	November 2022
Prospects for utilizing microbial consortia for lignin conversion Rodriguez, Alberto; Hirakawa, Matthew P.; Geiselman, Gina M. Frontiers in Chemical Engineering, Vol. 5 https://doi.org/10.3389/fceng.2023.1086881	journal	January 2023
Recent Biotechnology Advances in Bio-Conversion of Lignin to Lipids by Bacterial Cultures Wang, Huan; Peng, Xiaodong; Li, Hu Frontiers in Chemistry, Vol. 10 https://doi.org/10.3389/fchem.2022.894593	journal	April 2022
Yarrowia lipolytica as an Oleaginous Cell Factory Platform for Production of Fatty Acid-Based Biofuel and Bioproducts Abghari, Ali; Chen, Shulin Frontiers in Energy Research, Vol. 2 https://doi.org/10.3389/fenrg.2014.00021	journal	June 2014
A Review: Depolymerization of Lignin to Generate High-Value Bio-Products: Opportunities, Challenges, and Prospects Zhou, Ningning; Thilakarathna, W. P. D. Wass; He, Quan Sophia Frontiers in Energy Research, Vol. 9 https://doi.org/10.3389/fenrg.2021.758744	journal	January 2022
Revisiting Theoretical Tools and Approaches for the Valorization of Recalcitrant Lignocellulosic Biomass to Value-Added Chemicals Pham, Le Thanh Mai; Choudhary, Hemant; Gauttam, Rahul Frontiers in Energy Research, Vol. 10 https://doi.org/10.3389/fenrg.2022.863153	journal	July 2022
Evidence supporting dissimilatory and assimilatory lignin degradation in Enterobacter lignolyticus SCF1 DeAngelis, Kristen M.; Sharma, Deepak; Varney, Rebecca Frontiers in Microbiology, Vol. 4 https://doi.org/10.3389/fmicb.2013.00280	journal	January 2013
Utilizing Anaerobic Fungi for Two-stage Sugar Extraction and Biofuel Production from Lignocellulosic Biomass Ranganathan, Abhaya; Smith, Olivia P.; Youssef, Noha H. Frontiers in Microbiology, Vol. 8 https://doi.org/10.3389/fmicb.2017.00635	journal	April 2017
Enrichment of Bacteria From Eastern Mediterranean Sea Involved in Lignin Degradation via the Phenylacetyl-CoA Pathway Woo, Hannah L.; Hazen, Terry C. Frontiers in Microbiology, Vol. 9 https://doi.org/10.3389/fmicb.2018.00922	journal	May 2018
Bioprospecting Microbial Diversity for Lignin Valorization: Dry and Wet Screening Methods Gonçalves, Carolyne Caetano; Bruce, Thiago; Silva, Caio de Oliveira Gorgulho Frontiers in Microbiology, Vol. 11 https://doi.org/10.3389/fmicb.2020.01081	journal	June 2020
Bioprospecting of Novel Extremozymes From Prokaryotes—The Advent of Culture-Independent Methods Sysoev, Maksim; Grötzinger, Stefan W.; Renn, Dominik Frontiers in Microbiology, Vol. 12 https://doi.org/10.3389/fmicb.2021.630013	journal	February 2021
Whole-Genome Sequencing and Analysis of the White-Rot Fungus Ceriporia lacerata Reveals Its Phylogenetic Status and the Genetic Basis of Lignocellulose Degradation and Terpenoid Synthesis Mao, Zhitao; Yang, Ping; Liu, Huanhuan Frontiers in Microbiology, Vol. 13 https://doi.org/10.3389/fmicb.2022.880946	journal	May 2022
Recent Advances in Lignin Depolymerization Techniques: A Comparative Overview of Traditional and Greener Approaches Roy, Ranen; Rahman, Md Sajjadur; Amit, Tanvir A. Biomass, Vol. 2, Issue 3 https://doi.org/10.3390/biomass2030009	journal	July 2022
Lignocellulosic Biorefinery Technologies: A Perception into Recent Advances in Biomass Fractionation, Biorefineries, Economic Hurdles and Market Outlook K. N., Yogalakshmi; T. M., Mohamed Usman; S., Kavitha Fermentation, Vol. 9, Issue 3 https://doi.org/10.3390/fermentation9030238	journal	February 2023
Loops around the Heme Pocket Have a Critical Role in the Function and Stability of BsDyP from Bacillus subtilis Rodrigues, Carolina F.; Borges, Patrícia T.; Scocozza, Magali F. International Journal of Molecular Sciences, Vol. 22, Issue 19 https://doi.org/10.3390/ijms221910862	journal	October 2021
Design and Engineering of an Efficient Peroxidase Using Myoglobin for Dye Decolorization and Lignin Bioconversion Guo, Wen-Jie; Xu, Jia-Kun; Wu, Sheng-Tao International Journal of Molecular Sciences, Vol. 23, Issue 1 https://doi.org/10.3390/ijms23010413	journal	December 2021
iNovo479: Metabolic Modeling Provides a Roadmap to Optimize Bioproduct Yield from Deconstructed Lignin Aromatics by Novosphingobium aromaticivorans Linz, Alexandra M.; Ma, Yanjun; Scholz, Samuel Metabolites, Vol. 12, Issue 4 https://doi.org/10.3390/metabo12040366	journal	April 2022
Low-Temperature Biodegradation of Lignin-Derived Aromatic Model Monomers by the Cold-Adapted Yeast Rhodosporidiobolus colostri Isolated from Alpine Forest Soil Margesin, Rosa; Ludwikowski, Thomas Marek; Kutzner, Andrea Microorganisms, Vol. 10, Issue 3 https://doi.org/10.3390/microorganisms10030515	journal	February 2022
Expression of Pleurotus ostreatus Laccase Gene in Pichia pastoris and Its Degradation of Corn Stover Lignin Song, Qian; Deng, Xun; Song, Rui-Qing Microorganisms, Vol. 8, Issue 4 https://doi.org/10.3390/microorganisms8040601	journal	April 2020
Valorization of Lignin and Its Derivatives Using Yeast Putra, Filemon Jalu Nusantara; Kahar, Prihardi; Kondo, Akihiko Processes, Vol. 10, Issue 10 https://doi.org/10.3390/pr10102004	journal	October 2022
The Bacterial Degradation of Lignin—A Review Grgas, Dijana; Rukavina, Matea; Bešlo, Drago Water, Vol. 15, Issue 7 https://doi.org/10.3390/w15071272	journal	March 2023
Heterologous expression and characterization of a high redox potential laccase from Coriolopsis polyzona MUCL 38443 PİNar, Orkun; Tamerler, Candan; Yazgan KarataŞ, Ayten TURKISH JOURNAL OF BIOLOGY, Vol. 41 https://doi.org/10.3906/biy-1605-51	journal	January 2017

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