The critical role of lignin in lignocellulosic biomass conversion and recent pretreatment strategies: A comprehensive review

Yoo, Chang Geun; Meng, Xianzhi; Pu, Yunqiao Joseph; Ragauskas, Arthur J.

doi:10.1016/j.biortech.2020.122784

Title: The critical role of lignin in lignocellulosic biomass conversion and recent pretreatment strategies: A comprehensive review

Journal Article · Wed Apr 01 00:00:00 EDT 2020 · Bioresource Technology

DOI:https://doi.org/10.1016/j.biortech.2020.122784· OSTI ID:1649140

Yoo, Chang Geun ^[1]; Meng, Xianzhi ^[2];

^[3];

^[4]

State Univ. of New York (SUNY), Syracuse, NY (United States). College of Environmental Science and Forestry, Dept. of Paper and Bioprocess Engineering
Univ. of Tennessee, Knoxville, TN (United States). Dept. of Chemical and Biomolecular Engineering
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Biosciences Division and Center for Bioenergy Innovation (CBI), Joint Inst. for Biological Sciences
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Biosciences Division and Center for Bioenergy Innovation (CBI), Joint Inst. for Biological Sciences; Univ. of Tennessee, Knoxville, TN (United States). Dept. of Chemical and Biomolecular Engineering and Dept. of Forestry, Wildlife and Fisheries, Center of Renewable Carbon

Heterogeneity and rigidity of lignocellulose causing resistance to its deconstruction have provided technical and economic challenges in the current biomass conversion processes. Lignin has been considered as a crucial recalcitrance component in biomass utilization. An in-depth understanding of lignin properties and their influences on biomass conversion can provide clues to improve biomass utilization. Also, utilization of lignin can significantly increase the economic viability of biorefinery. Recent lignin-targeting pretreatments have aimed not only to overcome recalcitrance for biomass conversion but also to selectively fractionate lignin for lignin valorization. Numerous studies have been conducted in biomass characteristics and conversion technologies, and the role of lignin is critical for lignin valorization and biomass pretreatment development. In this review, we provide a comprehensive review of lignin-related biomass characteristics, the impact of lignin on the biological conversion of biomass, and recent lignin-targeting pretreatment strategies. The desired lignin properties in biorefinery and future pretreatment directions are also discussed.

View Accepted Manuscript (DOE)

View Accepted Manuscript (Publisher)

Cite

Export

Save

Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: AC05-00OR22725; FWP-ERKP752

OSTI ID:: 1649140

Alternate ID(s):: OSTI ID: 1595855

Journal Information:: Bioresource Technology, Vol. 301, Issue 1; ISSN 0960-8524

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

Citation Metrics:

Cited by: 270 works

Citation information provided by
Web of Science

References (125)

A critical review on the analysis of lignin carbohydrate bonds Giummarella, Nicola; Pu, Yunqiao; Ragauskas, Arthur J. Green Chemistry, Vol. 21, Issue 7 https://doi.org/10.1039/C8GC03606C	journal	January 2019
Kinetics and Mechanism of Tetrahydrofuran Synthesis via 1,4-Butanediol Dehydration in High-Temperature Water Hunter, Shawn E.; Ehrenberger, Carolyn E.; Savage, Phillip E. The Journal of Organic Chemistry, Vol. 71, Issue 16 https://doi.org/10.1021/jo061017o	journal	August 2006
Nonenzymatic Sugar Production from Biomass Using Biomass-Derived -Valerolactone Luterbacher, J. S.; Rand, J. M.; Alonso, D. M. Science, Vol. 343, Issue 6168 https://doi.org/10.1126/science.1246748	journal	January 2014
Mechanism of lignin inhibition of enzymatic biomass deconstruction Vermaas, Josh V.; Petridis, Loukas; Qi, Xianghong Biotechnology for Biofuels, Vol. 8, Issue 1 https://doi.org/10.1186/s13068-015-0379-8	journal	December 2015
Comparative Evaluation of Three Lignin Isolation Protocols for Various Wood Species Guerra, Anderson; Filpponen, Ilari; Lucia, Lucian A. Journal of Agricultural and Food Chemistry, Vol. 54, Issue 26 https://doi.org/10.1021/jf062433c	journal	December 2006
Integrated conversion of hemicellulose and cellulose from lignocellulosic biomass Alonso, David Martin; Wettstein, Stephanie G.; Mellmer, Max A. Energy Environ. Sci., Vol. 6, Issue 1 https://doi.org/10.1039/C2EE23617F	journal	January 2013
Structural Differences between the Lignin−Carbohydrate Complexes Present in Wood and in Chemical Pulps Lawoko, Martin; Henriksson, Gunnar; Gellerstedt, Göran Biomacromolecules, Vol. 6, Issue 6 https://doi.org/10.1021/bm058014q	journal	November 2005
A review on lignin structure, pretreatments, fermentation reactions and biorefinery potential Ponnusamy, Vinoth Kumar; Nguyen, Dinh Duc; Dharmaraja, Jeyaprakash Bioresource Technology, Vol. 271 https://doi.org/10.1016/j.biortech.2018.09.070	journal	January 2019
Lignin modification improves fermentable sugar yields for biofuel production Chen, Fang; Dixon, Richard A. Nature Biotechnology, Vol. 25, Issue 7, p. 759-761 https://doi.org/10.1038/nbt1316	journal	June 2007
THF co-solvent enhances hydrocarbon fuel precursor yields from lignocellulosic biomass Cai, Charles M.; Zhang, Taiying; Kumar, Rajeev Green Chemistry, Vol. 15, Issue 11 https://doi.org/10.1039/c3gc41214h	journal	January 2013
Lignin-enzyme interaction: Mechanism, mitigation approach, modeling, and research prospects Li, Xiang; Zheng, Yi Biotechnology Advances, Vol. 35, Issue 4 https://doi.org/10.1016/j.biotechadv.2017.03.010	journal	July 2017
Stimulation and inhibition of enzymatic hydrolysis by organosolv lignins as determined by zeta potential and hydrophobicity Huang, Yang; Sun, Shaolong; Huang, Chen Biotechnology for Biofuels, Vol. 10, Issue 1 https://doi.org/10.1186/s13068-017-0853-6	journal	June 2017
Lignin-first biomass fractionation using a hybrid organosolv – Steam explosion pretreatment technology improves the saccharification and fermentability of spruce biomass Matsakas, Leonidas; Raghavendran, Vijayendran; Yakimenko, Olga Bioresource Technology, Vol. 273 https://doi.org/10.1016/j.biortech.2018.11.055	journal	February 2019
Engineering Cel7A carbohydrate binding module and linker for reduced lignin inhibition: Engineering a Lignin-Resistant Cel7A Strobel, Kathryn L.; Pfeiffer, Katherine A.; Blanch, Harvey W. Biotechnology and Bioengineering, Vol. 113, Issue 6 https://doi.org/10.1002/bit.25889	journal	December 2015
Applications of deep eutectic solvents in biotechnology and bioengineering—Promises and challenges Mbous, Yves Paul; Hayyan, Maan; Hayyan, Adeeb Biotechnology Advances, Vol. 35, Issue 2 https://doi.org/10.1016/j.biotechadv.2016.11.006	journal	March 2017
Biological pretreatment of lignocellulosic biomass – An overview Sindhu, Raveendran; Binod, Parameswaran; Pandey, Ashok Bioresource Technology, Vol. 199 https://doi.org/10.1016/j.biortech.2015.08.030	journal	January 2016
Biphasic 2-methyltetrahydrofuran/oxalic acid/water pretreatment to enhance cellulose enzymatic hydrolysis and lignin valorization Li, Shu-Xian; Li, Ming-Fei; Bian, Jing Bioresource Technology, Vol. 243 https://doi.org/10.1016/j.biortech.2017.07.075	journal	November 2017
Structural Characterization and Comparison of Switchgrass Ball-milled Lignin Before and After Dilute Acid Pretreatment Samuel, Reichel; Pu, Yunqiao; Raman, Babu Applied Biochemistry and Biotechnology, Vol. 162, Issue 1 https://doi.org/10.1007/s12010-009-8749-y	journal	August 2009
Interactive forces between lignin and cellulase as determined by atomic force microscopy Qin, Chengrong; Clarke, Kimberley; Li, Kecheng Biotechnology for Biofuels, Vol. 7, Issue 1 https://doi.org/10.1186/1754-6834-7-65	journal	January 2014
A mild biomass pretreatment using γ-valerolactone for concentrated sugar production Shuai, Li; Questell-Santiago, Ydna M.; Luterbacher, Jeremy S. Green Chemistry, Vol. 18, Issue 4 https://doi.org/10.1039/C5GC02489G	journal	January 2016
Ionic liquids: Promising green solvents for lignocellulosic biomass utilization Yoo, Chang Geun; Pu, Yunqiao; Ragauskas, Arthur J. Current Opinion in Green and Sustainable Chemistry, Vol. 5 https://doi.org/10.1016/j.cogsc.2017.03.003	journal	June 2017
Lignin plays a negative role in the biochemical process for producing lignocellulosic biofuels Zeng, Yining; Zhao, Shuai; Yang, Shihui Current Opinion in Biotechnology, Vol. 27 https://doi.org/10.1016/j.copbio.2013.09.008	journal	June 2014
Effects of organosolv and ammonia pretreatments on lignin properties and its inhibition for enzymatic hydrolysis Yoo, Chang Geun; Li, Mi; Meng, Xianzhi Green Chemistry, Vol. 19, Issue 8 https://doi.org/10.1039/C6GC03627A	journal	January 2017
Lignin from hydrothermally pretreated grass biomass retards enzymatic cellulose degradation by acting as a physical barrier rather than by inducing nonproductive adsorption of enzymes Djajadi, Demi T.; Jensen, Mads M.; Oliveira, Marlene Biotechnology for Biofuels, Vol. 11, Issue 1 https://doi.org/10.1186/s13068-018-1085-0	journal	April 2018
Green Processing of Lignocellulosic Biomass and Its Derivatives in Deep Eutectic Solvents Tang, Xing; Zuo, Miao; Li, Zheng ChemSusChem, Vol. 10, Issue 13 https://doi.org/10.1002/cssc.201700457	journal	May 2017
Understanding Lignin Fractionation and Characterization from Engineered Switchgrass Treated by an Aqueous Ionic Liquid Liu, Enshi; Li, Mi; Das, Lalitendu ACS Sustainable Chemistry & Engineering, Vol. 6, Issue 5 https://doi.org/10.1021/acssuschemeng.8b00384	journal	March 2018
Temperature and pH influence adsorption of cellobiohydrolase onto lignin by changing the protein properties Lu, Xianqin; Wang, Can; Li, Xuezhi Bioresource Technology, Vol. 245 https://doi.org/10.1016/j.biortech.2017.08.139	journal	December 2017
Lignosulfonate-mediated cellulase adsorption: enhanced enzymatic saccharification of lignocellulose through weakening nonproductive binding to lignin Wang, Zhaojiang; Zhu, Jy; Fu, Yingjuan Biotechnology for Biofuels, Vol. 6, Issue 1 https://doi.org/10.1186/1754-6834-6-156	journal	January 2013
Ultrafast fractionation of lignocellulosic biomass by microwave-assisted deep eutectic solvent pretreatment Chen, Zhu; Wan, Caixia Bioresource Technology, Vol. 250 https://doi.org/10.1016/j.biortech.2017.11.066	journal	February 2018
Organosolv pretreatment with various catalysts for enhancing enzymatic hydrolysis of pitch pine (Pinus rigida) Park, Nahyun; Kim, Hye-Yun; Koo, Bon-Wook Bioresource Technology, Vol. 101, Issue 18 https://doi.org/10.1016/j.biortech.2010.04.020	journal	September 2010
Recent Efforts to Prevent Undesirable Reactions From Fractionation to Depolymerization of Lignin: Toward Maximizing the Value From Lignin Kim, Kwang Ho; Kim, Chang Soo Frontiers in Energy Research, Vol. 6 https://doi.org/10.3389/fenrg.2018.00092	journal	September 2018
The isolation, characterization and effect of lignin isolated from steam pretreated Douglas-fir on the enzymatic hydrolysis of cellulose Nakagame, Seiji; Chandra, Richard P.; Kadla, John F. Bioresource Technology, Vol. 102, Issue 6 https://doi.org/10.1016/j.biortech.2010.12.082	journal	March 2011
Adsorption of cellobiohydrolases I onto lignin fractions from dilute acid pretreated Broussonetia papyrifera Yao, Lan; Yang, Haitao; Yoo, Chang Geun Bioresource Technology, Vol. 244 https://doi.org/10.1016/j.biortech.2017.08.024	journal	November 2017
Remarkable solvent and extractable lignin effects on enzymatic digestibility of organosolv pretreated hardwood Lai, Chenhuan; Tu, Maobing; Li, Mi Bioresource Technology, Vol. 156 https://doi.org/10.1016/j.biortech.2014.01.030	journal	March 2014
Lignin–carbohydrate complexes: properties, applications, analyses, and methods of extraction: a review Tarasov, Dmitry; Leitch, Mathew; Fatehi, Pedram Biotechnology for Biofuels, Vol. 11, Issue 1 https://doi.org/10.1186/s13068-018-1262-1	journal	September 2018
Pandoraea sp. B-6 assists the deep eutectic solvent pretreatment of rice straw via promoting lignin depolymerization Liu, Dan; Yan, Xu; Zhuo, Shengnan Bioresource Technology, Vol. 257 https://doi.org/10.1016/j.biortech.2018.02.029	journal	June 2018
New insights into the structure and composition of technical lignins: a comparative characterisation study Constant, Sandra; Wienk, Hans L. J.; Frissen, Augustinus E. Green Chemistry, Vol. 18, Issue 9 https://doi.org/10.1039/C5GC03043A	journal	January 2016
Improvement of anaerobic degradation by white-rot fungi pretreatment of lignocellulosic biomass: A review Rouches, E.; Herpoël-Gimbert, I.; Steyer, J. P. Renewable and Sustainable Energy Reviews, Vol. 59 https://doi.org/10.1016/j.rser.2015.12.317	journal	June 2016
Lignin content in natural Populus variants affects sugar release Studer, M. H.; DeMartini, J. D.; Davis, M. F. Proceedings of the National Academy of Sciences, Vol. 108, Issue 15, p. 6300-6305 https://doi.org/10.1073/pnas.1009252108	journal	March 2011
A new face for biomass breakdown Fushinobu, Shinya Nature Chemical Biology, Vol. 10, Issue 2 https://doi.org/10.1038/nchembio.1434	journal	December 2013
Woody biomass pretreatment for cellulosic ethanol production: Technology and energy consumption evaluation☆ Zhu, J. Y.; Pan, X. J. Bioresource Technology, Vol. 101, Issue 13 https://doi.org/10.1016/j.biortech.2009.11.007	journal	July 2010
Pseudo-lignin formation and its impact on enzymatic hydrolysis Hu, Fan; Jung, Seokwon; Ragauskas, Arthur Bioresource Technology, Vol. 117 https://doi.org/10.1016/j.biortech.2012.04.037	journal	August 2012
Effect of Lignin Chemistry on the Enzymatic Hydrolysis of Woody Biomass Yu, Zhiying; Gwak, Ki-Seob; Treasure, Trevor ChemSusChem, Vol. 7, Issue 7 https://doi.org/10.1002/cssc.201400042	journal	June 2014
Effect of alkaline lignin modification on cellulase–lignin interactions and enzymatic saccharification yield Ying, Wenjun; Shi, Zhengjun; Yang, Haiyan Biotechnology for Biofuels, Vol. 11, Issue 1 https://doi.org/10.1186/s13068-018-1217-6	journal	August 2018
Increasing the revenue from lignocellulosic biomass: Maximizing feedstock utilization Alonso, David Martin; Hakim, Sikander H.; Zhou, Shengfei Science Advances, Vol. 3, Issue 5 https://doi.org/10.1126/sciadv.1603301	journal	May 2017
Adsorption and mechanism of cellulase enzymes onto lignin isolated from corn stover pretreated with liquid hot water Lu, Xianqin; Zheng, Xiaoju; Li, Xuezhi Biotechnology for Biofuels, Vol. 9, Issue 1 https://doi.org/10.1186/s13068-016-0531-0	journal	June 2016
Biomass recalcitrance. Part I: the chemical compositions and physical structures affecting the enzymatic hydrolysis of lignocellulose Zhao, Xuebing; Zhang, Lihua; Liu, Dehua Biofuels, Bioproducts and Biorefining, Vol. 6, Issue 4 https://doi.org/10.1002/bbb.1331	journal	March 2012
Heteropoly acids enhanced neutral deep eutectic solvent pretreatment for enzymatic hydrolysis and ethanol fermentation of Miscanthus x giganteus under mild conditions Guo, Zongwei; Zhang, Qilin; You, Tingting Bioresource Technology, Vol. 293 https://doi.org/10.1016/j.biortech.2019.122036	journal	December 2019
White-Rot Fungi pretreatment of lignocellulosic biomass for anaerobic digestion: Impact of glucose supplementation Rouches, E.; Zhou, S.; Steyer, J. P. Process Biochemistry, Vol. 51, Issue 11 https://doi.org/10.1016/j.procbio.2016.02.003	journal	November 2016
Effective conversion of biomass into bromomethylfurfural, furfural, and depolymerized lignin in lithium bromide molten salt hydrate of a biphasic system Yoo, Chang Geun; Zhang, Shuting; Pan, Xuejun RSC Advances, Vol. 7, Issue 1 https://doi.org/10.1039/C6RA25025D	journal	January 2017
Selective deconstruction of hemicellulose and lignin with producing derivatives by sequential pretreatment process for biorefining concept Choi, June-Ho; Park, Se-Yeong; Kim, Jong-Hwa Bioresource Technology, Vol. 291 https://doi.org/10.1016/j.biortech.2019.121913	journal	November 2019
Quantitative Structures and Thermal Properties of Birch Lignins after Ionic Liquid Pretreatment Wen, Jia-Long; Sun, Shao-Long; Xue, Bai-Liang Journal of Agricultural and Food Chemistry, Vol. 61, Issue 3 https://doi.org/10.1021/jf3051939	journal	January 2013
Formaldehyde stabilization facilitates lignin monomer production during biomass depolymerization Shuai, Li; Amiri, Masoud Talebi; Questell-Santiago, Ydna M. Science, Vol. 354, Issue 6310 https://doi.org/10.1126/science.aaf7810	journal	October 2016
An “ideal lignin” facilitates full biomass utilization Li, Yanding; Shuai, Li; Kim, Hoon Science Advances, Vol. 4, Issue 9 https://doi.org/10.1126/sciadv.aau2968	journal	September 2018
A review on alkaline pretreatment technology for bioconversion of lignocellulosic biomass Kim, Jun Seok; Lee, Y. Y.; Kim, Tae Hyun Bioresource Technology, Vol. 199 https://doi.org/10.1016/j.biortech.2015.08.085	journal	January 2016
Biomass pretreatment using deep eutectic solvents from lignin derived phenols Kim, Kwang Ho; Dutta, Tanmoy; Sun, Jian Green Chemistry, Vol. 20, Issue 4 https://doi.org/10.1039/C7GC03029K	journal	January 2018
Butanol production from renewable biomass by clostridia Jang, Yu-Sin; Malaviya, Alok; Cho, Changhee Bioresource Technology, Vol. 123 https://doi.org/10.1016/j.biortech.2012.07.104	journal	November 2012
Organosolv pretreatment of plant biomass for enhanced enzymatic saccharification Zhang, Zhanying; Harrison, Mark D.; Rackemann, Darryn W. Green Chemistry, Vol. 18, Issue 2 https://doi.org/10.1039/C5GC02034D	journal	January 2016
Predicting Enzyme Adsorption to Lignin Films by Calculating Enzyme Surface Hydrophobicity Sammond, Deanne W.; Yarbrough, John M.; Mansfield, Elisabeth Journal of Biological Chemistry, Vol. 289, Issue 30 https://doi.org/10.1074/jbc.M114.573642	journal	May 2014
Comparison of catalytically non-productive adsorption of fungal proteins to lignins and pseudo-lignin using isobaric mass tagging Wang, Zhao; Jönsson, Leif J. Bioresource Technology, Vol. 268 https://doi.org/10.1016/j.biortech.2018.07.149	journal	November 2018
An In-Depth Understanding of Biomass Recalcitrance Using Natural Poplar Variants as the Feedstock Meng, Xianzhi; Pu, Yunqiao; Yoo, Chang Geun ChemSusChem, Vol. 10, Issue 1 https://doi.org/10.1002/cssc.201601303	journal	December 2016
A review on bioconversion of lignocellulosic biomass to H2: Key challenges and new insights Ren, Nan-Qi; Zhao, Lei; Chen, Chuan Bioresource Technology, Vol. 215 https://doi.org/10.1016/j.biortech.2016.03.124	journal	September 2016
Deep eutectic solvent pretreatment enabling full utilization of switchgrass Chen, Zhu; Reznicek, Wesley D.; Wan, Caixia Bioresource Technology, Vol. 263 https://doi.org/10.1016/j.biortech.2018.04.058	journal	September 2018
Disparate roles of solvent extractable lignin and residual bulk lignin in enzymatic hydrolysis of pretreated sweetgum Lai, Chenhuan; Tu, Maobing; Yong, Qiang RSC Advances, Vol. 5, Issue 119 https://doi.org/10.1039/C5RA22308C	journal	January 2015
Facile pretreatment of lignocellulosic biomass using deep eutectic solvents Zhang, Cheng-Wu; Xia, Shu-Qian; Ma, Pei-Sheng Bioresource Technology, Vol. 219 https://doi.org/10.1016/j.biortech.2016.07.026	journal	November 2016
Insights of biomass recalcitrance in natural Populus trichocarpa variants for biomass conversion Yoo, Chang Geun; Yang, Yongil; Pu, Yunqiao Green Chemistry, Vol. 19, Issue 22 https://doi.org/10.1039/C7GC02219K	journal	January 2017
Current Understanding of the Correlation of Lignin Structure with Biomass Recalcitrance Li, Mi; Pu, Yunqiao; Ragauskas, Arthur J. Frontiers in Chemistry, Vol. 4 https://doi.org/10.3389/fchem.2016.00045	journal	November 2016
Understanding the Physicochemical Characteristics and the Improved Enzymatic Saccharification of Corn Stover Pretreated with Aqueous and Gaseous Ammonia Yoo, Chang Geun; Kim, Hoon; Lu, Fachuang BioEnergy Research, Vol. 9, Issue 1 https://doi.org/10.1007/s12155-015-9662-6	journal	August 2015
Structural features of dilute acid, steam exploded, and alkali pretreated mustard stalk and their impact on enzymatic hydrolysis Kapoor, Manali; Raj, Tirath; Vijayaraj, M. Carbohydrate Polymers, Vol. 124 https://doi.org/10.1016/j.carbpol.2015.02.044	journal	June 2015
Chemical Transformations of Poplar Lignin during Cosolvent Enhanced Lignocellulosic Fractionation Process Meng, Xianzhi; Parikh, Aakash; Seemala, Bhogeswararao ACS Sustainable Chemistry & Engineering, Vol. 6, Issue 7 https://doi.org/10.1021/acssuschemeng.8b01028	journal	May 2018
Integration of renewable deep eutectic solvents with engineered biomass to achieve a closed-loop biorefinery Kim, Kwang Ho; Eudes, Aymerick; Jeong, Keunhong Proceedings of the National Academy of Sciences, Vol. 116, Issue 28 https://doi.org/10.1073/pnas.1904636116	journal	June 2019
Assessing the Facile Pretreatments of Bagasse for Efficient Enzymatic Conversion and Their Impacts on Structural and Chemical Properties Satlewal, Alok; Agrawal, Ruchi; Das, Parthapratim ACS Sustainable Chemistry & Engineering, Vol. 7, Issue 1 https://doi.org/10.1021/acssuschemeng.8b04773	journal	November 2018
Short-time deep eutectic solvent pretreatment for enhanced enzymatic saccharification and lignin valorization Guo, Zongwei; Zhang, Qilin; You, Tingting Green Chemistry, Vol. 21, Issue 11 https://doi.org/10.1039/C9GC00704K	journal	January 2019
Toward a fundamental understanding of cellulase-lignin interactions in the whole slurry enzymatic saccharification process: Elucidating Cellulase-Lignin Interactions for Whole Slurry Saccharification Liu, Hao; Sun, Jianliang; Leu, Shao-Yuan Biofuels, Bioproducts and Biorefining, Vol. 10, Issue 5 https://doi.org/10.1002/bbb.1670	journal	July 2016
Lignin monomer production integrated into the γ-valerolactone sugar platform Luterbacher, Jeremy S.; Azarpira, Ali; Motagamwala, Ali H. Energy & Environmental Science, Vol. 8, Issue 9 https://doi.org/10.1039/C5EE01322D	journal	January 2015
Structural Characterization of Switchgrass Lignin after Ethanol Organosolv Pretreatment Hu, Gang; Cateto, Carolina; Pu, Yunqiao Energy & Fuels, Vol. 26, Issue 1 https://doi.org/10.1021/ef201477p	journal	December 2011
Mild alkali-pretreatment effectively extracts guaiacyl-rich lignin for high lignocellulose digestibility coupled with largely diminishing yeast fermentation inhibitors in Miscanthus Li, Ming; Si, Shengli; Hao, Bo Bioresource Technology, Vol. 169 https://doi.org/10.1016/j.biortech.2014.07.017	journal	October 2014
Biomass Recalcitrance: Engineering Plants and Enzymes for Biofuels Production Himmel, M. E.; Ding, S.-Y.; Johnson, D. K. Science, Vol. 315, Issue 5813, p. 804-807 https://doi.org/10.1126/science.1137016	journal	February 2007
Inhibition of cellulase, xylanase and β-glucosidase activities by softwood lignin preparations Berlin, Alex; Balakshin, Mikhail; Gilkes, Neil Journal of Biotechnology, Vol. 125, Issue 2, p. 198-209 https://doi.org/10.1016/j.jbiotec.2006.02.021	journal	September 2006
Contrasting effects of hardwood and softwood organosolv lignins on enzymatic hydrolysis of lignocellulose Lai, Chenhuan; Tu, Maobing; Shi, Zhiqiang Bioresource Technology, Vol. 163 https://doi.org/10.1016/j.biortech.2014.04.065	journal	July 2014
Differences in the adsorption of enzymes onto lignins from diverse types of lignocellulosic biomass and the underlying mechanism Guo, Fenfen; Shi, Wenjing; Sun, Wan Biotechnology for Biofuels, Vol. 7, Issue 1 https://doi.org/10.1186/1754-6834-7-38	journal	January 2014
Significance of Lignin S/G Ratio in Biomass Recalcitrance of Populus trichocarpa Variants for Bioethanol Production Yoo, Chang Geun; Dumitrache, Alexandru; Muchero, Wellington ACS Sustainable Chemistry & Engineering, Vol. 6, Issue 2 https://doi.org/10.1021/acssuschemeng.7b03586	journal	December 2017
Deposition of Lignin Droplets Produced During Dilute Acid Pretreatment of Maize Stems Retards Enzymatic Hydrolysis of Cellulose Selig, M. J.; Viamajala, S.; Decker, S. R. Biotechnology Progress, Vol. 23, Issue 6 https://doi.org/10.1021/bp0702018	journal	December 2007
Negatively Supercharging Cellulases Render Them Lignin-Resistant Whitehead, Timothy A.; Bandi, Chandra K.; Berger, Marissa ACS Sustainable Chemistry & Engineering, Vol. 5, Issue 7 https://doi.org/10.1021/acssuschemeng.7b01202	journal	May 2017
Evaluation of the action of Tween 20 non-ionic surfactant during enzymatic hydrolysis of lignocellulose: Pretreatment, hydrolysis conditions and lignin structure Chen, Yu-An; Zhou, Yan; Qin, Yanlin Bioresource Technology, Vol. 269 https://doi.org/10.1016/j.biortech.2018.08.119	journal	December 2018
The reactivity of lignin carbohydrate complex (LCC) during manufacture of dissolving sulfite pulp from softwood Deshpande, Raghu; Giummarella, Nicola; Henriksson, Gunnar Industrial Crops and Products, Vol. 115 https://doi.org/10.1016/j.indcrop.2018.02.038	journal	May 2018
CELF pretreatment of corn stover boosts ethanol titers and yields from high solids SSF with low enzyme loadings Nguyen, Thanh Yen; Cai, Charles M.; Osman, Omar Green Chemistry, Vol. 18, Issue 6 https://doi.org/10.1039/C5GC01977J	journal	January 2016
Efficient catalytic system for the direct transformation of lignocellulosic biomass to furfural and 5-hydroxymethylfurfural Zhang, Luxin; Xi, Guoyun; Zhang, Jiaxin Bioresource Technology, Vol. 224 https://doi.org/10.1016/j.biortech.2016.11.097	journal	January 2017
New Method for Highly Efficient Conversion of Biomass-Derived Levulinic Acid to γ-Valerolactone in Water without Precious Metal Catalysts Zhong, Heng; Li, Qiuju; Liu, Jianke ACS Sustainable Chemistry & Engineering, Vol. 5, Issue 8 https://doi.org/10.1021/acssuschemeng.7b00623	journal	June 2017
Review of current and future softwood kraft lignin process chemistry Chakar, Fadi S.; Ragauskas, Arthur J. Industrial Crops and Products, Vol. 20, Issue 2 https://doi.org/10.1016/j.indcrop.2004.04.016	journal	September 2004
Effect of hydrothermal pretreatment severity on lignin inhibition in enzymatic hydrolysis Kellock, Miriam; Maaheimo, Hannu; Marjamaa, Kaisa Bioresource Technology, Vol. 280 https://doi.org/10.1016/j.biortech.2019.02.051	journal	May 2019
Organic solvent pretreatment of lignocellulosic biomass for biofuels and biochemicals: A review Zhang, Ke; Pei, Zhijian; Wang, Donghai Bioresource Technology, Vol. 199 https://doi.org/10.1016/j.biortech.2015.08.102	journal	January 2016
Lignocellulose pretreatment technologies affect the level of enzymatic cellulose oxidation by LPMO Rodríguez-Zúñiga, Ursula Fabiola; Cannella, David; Giordano, Roberto de Campos Green Chemistry, Vol. 17, Issue 5 https://doi.org/10.1039/C4GC02179G	journal	January 2015
Direct evidence for α ether linkage between lignin and carbohydrates in wood cell walls Nishimura, Hiroshi; Kamiya, Akihiro; Nagata, Takashi Scientific Reports, Vol. 8, Issue 1 https://doi.org/10.1038/s41598-018-24328-9	journal	April 2018
Lignosulfonate To Enhance Enzymatic Saccharification of Lignocelluloses: Role of Molecular Weight and Substrate Lignin Zhou, Haifeng; Lou, Hongming; Yang, Dongjie Industrial & Engineering Chemistry Research, Vol. 52, Issue 25 https://doi.org/10.1021/ie401085k	journal	June 2013
Advanced Biorefinery based on the Fractionation of Biomass in γ-Valerolactone and Water Fang, Wenwen; Sixta, Herbert ChemSusChem, Vol. 8, Issue 1 https://doi.org/10.1002/cssc.201402821	journal	November 2014
Enhanced enzymatic digestibility of mixed wood sawdust by lignin modification with naphthol derivatives during dilute acid pretreatment Lai, Chenhuan; Yang, Bo; He, Juan Bioresource Technology, Vol. 269 https://doi.org/10.1016/j.biortech.2018.08.086	journal	December 2018
Lignin Biosynthesis and Structure Vanholme, R.; Demedts, B.; Morreel, K. Plant Physiology, Vol. 153, Issue 3, p. 895-905 https://doi.org/10.1104/pp.110.155119	journal	May 2010
Charge engineering of cellulases improves ionic liquid tolerance and reduces lignin inhibition: Impact of Charge on Cellulase Activity in ILs Nordwald, Erik M.; Brunecky, Roman; Himmel, Michael E. Biotechnology and Bioengineering, Vol. 111, Issue 8 https://doi.org/10.1002/bit.25216	journal	March 2014
Enhancing the enzymatic hydrolysis of lignocellulosic biomass by increasing the carboxylic acid content of the associated lignin Nakagame, Seiji; Chandra, Richard P.; Kadla, John F. Biotechnology and Bioengineering, Vol. 108, Issue 3 https://doi.org/10.1002/bit.22981	journal	November 2010
Lignin Valorization: Improving Lignin Processing in the Biorefinery Ragauskas, A. J.; Beckham, G. T.; Biddy, M. J. Science, Vol. 344, Issue 6185, p. 1246843-1246843 https://doi.org/10.1126/science.1246843	journal	May 2014
Lignin-based polyoxyethylene ether enhanced enzymatic hydrolysis of lignocelluloses by dispersing cellulase aggregates Lin, Xuliang; Qiu, Xueqing; Yuan, Long Bioresource Technology, Vol. 185 https://doi.org/10.1016/j.biortech.2015.02.067	journal	June 2015
Coupling metal halides with a co-solvent to produce furfural and 5-HMF at high yields directly from lignocellulosic biomass as an integrated biofuels strategy Cai, Charles M.; Nagane, Nikhil; Kumar, Rajeev Green Chem., Vol. 16, Issue 8 https://doi.org/10.1039/C4GC00747F	journal	January 2014
Survey of Lignin-Structure Changes and Depolymerization during Ionic Liquid Pretreatment Dutta, Tanmoy; Isern, Nancy G.; Sun, Jian ACS Sustainable Chemistry & Engineering, Vol. 5, Issue 11 https://doi.org/10.1021/acssuschemeng.7b02123	journal	September 2017
Structural elucidation of lignin–carbohydrate complex (LCC) preparations and lignin from Arundo donax Linn You, Ting-Ting; Zhang, Li-Ming; Zhou, Su-Kun Industrial Crops and Products, Vol. 71 https://doi.org/10.1016/j.indcrop.2015.03.070	journal	September 2015
Enzymatic cellulose oxidation is linked to lignin by long-range electron transfer Westereng, Bjørge; Cannella, David; Wittrup Agger, Jane Scientific Reports, Vol. 5, Issue 1 https://doi.org/10.1038/srep18561	journal	December 2015
Co-solvent Pretreatment Reduces Costly Enzyme Requirements for High Sugar and Ethanol Yields from Lignocellulosic Biomass Nguyen, Thanh Yen; Cai, Charles M.; Kumar, Rajeev ChemSusChem, Vol. 8, Issue 10 https://doi.org/10.1002/cssc.201403045	journal	February 2015
Influence of lignin addition on the enzymatic digestibility of pretreated lignocellulosic biomasses Wang, Wangxia; Zhu, Yangsu; Du, Jing Bioresource Technology, Vol. 181 https://doi.org/10.1016/j.biortech.2015.01.026	journal	April 2015
Correlation between lignin physicochemical properties and inhibition to enzymatic hydrolysis of cellulose: Lignin Properties and Enzymatic Hydrolysis Yang, Qiang; Pan, Xuejun Biotechnology and Bioengineering, Vol. 113, Issue 6 https://doi.org/10.1002/bit.25903	journal	December 2015
RETRACTED: Corn stover pretreatment by metal oxides for improving lignin removal and reducing sugar degradation and water usage Li, Jun; Zhang, Meng; Li, Jun Bioresource Technology, Vol. 263 https://doi.org/10.1016/j.biortech.2018.05.006	journal	September 2018
Lignin–Enzyme Interactions in the Hydrolysis of Lignocellulosic Biomass dos Santos, Antonio Carlos; Ximenes, Eduardo; Kim, Youngmi Trends in Biotechnology, Vol. 37, Issue 5 https://doi.org/10.1016/j.tibtech.2018.10.010	journal	May 2019
Downregulation of pectin biosynthesis gene GAUT4 leads to reduced ferulate and lignin-carbohydrate cross-linking in switchgrass Li, Mi; Yoo, Chang Geun; Pu, Yunqiao Communications Biology, Vol. 2, Issue 1 https://doi.org/10.1038/s42003-018-0265-6	journal	January 2019
Lignin-first biomass fractionation: the advent of active stabilisation strategies Renders, T.; Van den Bosch, S.; Koelewijn, S. -F. Energy & Environmental Science, Vol. 10, Issue 7 https://doi.org/10.1039/C7EE01298E	journal	January 2017
The adsorption properties of endoglucanase to lignin and their impact on hydrolysis Lu, Xianqin; Feng, Xiaoting; Li, Xuezhi Bioresource Technology, Vol. 267 https://doi.org/10.1016/j.biortech.2018.06.031	journal	November 2018
Visualizing lignin coalescence and migration through maize cell walls following thermochemical pretreatment Donohoe, Bryon S.; Decker, Stephen R.; Tucker, Melvin P. Biotechnology and Bioengineering, Vol. 101, Issue 5 https://doi.org/10.1002/bit.21959	journal	December 2008
2D NMR characterization of wheat straw residual lignin after dilute acid pretreatment with different severities Jensen, Anders; Cabrera, Yohanna; Hsieh, Chia-Wen Holzforschung, Vol. 71, Issue 6 https://doi.org/10.1515/hf-2016-0112	journal	June 2017
Structural features of mildly fractionated lignin carbohydrate complexes (LCC) from spruce Giummarella, Nicola; Zhang, Liming; Henriksson, Gunnar RSC Advances, Vol. 6, Issue 48 https://doi.org/10.1039/C6RA02399A	journal	January 2016
Impact of engineered lignin composition on biomass recalcitrance and ionic liquid pretreatment efficiency Shi, Jian; Pattathil, Sivakumar; Parthasarathi, Ramakrishnan Green Chemistry, Vol. 18, Issue 18 https://doi.org/10.1039/C6GC01193D	journal	January 2016
Natural deep eutectic solvents for lignocellulosic biomass pretreatment: Recent developments, challenges and novel opportunities Satlewal, Alok; Agrawal, Ruchi; Bhagia, Samarthya Biotechnology Advances, Vol. 36, Issue 8 https://doi.org/10.1016/j.biotechadv.2018.08.009	journal	December 2018
γ-Valerolactone—a sustainable liquid for energy and carbon-based chemicals Horváth, István T.; Mehdi, Hasan; Fábos, Viktória Green Chem., Vol. 10, Issue 2 https://doi.org/10.1039/B712863K	journal	January 2008
Structural elucidation of whole lignin from Eucalyptus based on preswelling and enzymatic hydrolysis Wen, Jia-Long; Sun, Shao-Long; Yuan, Tong-Qi Green Chemistry, Vol. 17, Issue 3 https://doi.org/10.1039/C4GC01889C	journal	January 2015
The sequential Fenton oxidation and sulfomethylation pretreatment for alleviating the negative effects of lignin in enzymatic saccharification of sugarcane bagasse Ying, Wenjun; Xu, Gaofeng; Yang, Haiyan Bioresource Technology, Vol. 286 https://doi.org/10.1016/j.biortech.2019.121392	journal	August 2019
Overcoming factors limiting high-solids fermentation of lignocellulosic biomass to ethanol Nguyen, Thanh Yen; Cai, Charles M.; Kumar, Rajeev Proceedings of the National Academy of Sciences, Vol. 114, Issue 44 https://doi.org/10.1073/pnas.1704652114	journal	October 2017
Effect of the isoelectric point of pH-responsive lignin-based amphoteric surfactant on the enzymatic hydrolysis of lignocellulose Zhan, Xuejuan; Cai, Cheng; Pang, Yuxia Bioresource Technology, Vol. 283 https://doi.org/10.1016/j.biortech.2019.03.026	journal	July 2019
Cellulase adsorption on lignin: A roadblock for economic hydrolysis of biomass Saini, Jitendra Kumar; Patel, Anil Kumar; Adsul, Mukund Renewable Energy, Vol. 98 https://doi.org/10.1016/j.renene.2016.03.089	journal	December 2016

Cited By (1)

Constraints and advances in high-solids enzymatic hydrolysis of lignocellulosic biomass: a critical review da Silva, Ayla Sant’Ana; Espinheira, Roberta Pereira; Teixeira, Ricardo Sposina Sobral Biotechnology for Biofuels, Vol. 13, Issue 1 https://doi.org/10.1186/s13068-020-01697-w	journal	March 2020

Similar Records

Recent advances in biomass pretreatment using biphasic solvent systems

Journal Article · Fri Feb 24 00:00:00 EST 2023 · Green Chemistry · OSTI ID:1649140

Li, Ruolin; Zheng, Yayue; Zhao, Xiaoxue; +4 more

Natural deep eutectic solvents for lignocellulosic biomass pretreatment: Recent developments, challenges and novel opportunities

Journal Article · Wed Sep 05 00:00:00 EDT 2018 · Biotechnology Advances · OSTI ID:1649140

Satlewal, Alok; Agrawal, Ruchi; Bhagia, Samarthya; +2 more

Effect of lignin content on changes occurring in poplar cellulose ultrastructure during dilute acid pretreatment

Journal Article · Tue Oct 14 00:00:00 EDT 2014 · Biotechnology for Biofuels · OSTI ID:1649140

Sun, Qining; Foston, Marcus; Meng, Xianzhi; +8 more

Related Subjects

09 BIOMASS FUELS
lignin characteristics
recalcitrance
biorefinery
lignin inhibition
lignin valorization

Title: The critical role of lignin in lignocellulosic biomass conversion and recent pretreatment strategies: A comprehensive review

Citation Formats

References (125)

Cited By (1)

Similar Records

Related Subjects