Prophylactic Cranial Irradiation in Patients With High-Risk Metastatic Non-Small Cell Lung Cancer: Quality of Life and Neurocognitive Analysis of a Randomized Phase II Study

Journal Article · Wed Sep 15 04:00:00 EDT 2021 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/J.IJROBP.2021.04.017· OSTI ID:23198760

Maldonado, Federico ^[1]; Gonzalez-Ling, Ana; Oñate-Ocaña, Luis F.; Cabrera-Miranda, Luis Antonio; Zatarain-Barrón, Zyanya Lucia; Turcott, Jenny G.; Flores-Estrada, Diana; Lozano-Ruiz, Francisco ^[2]; Cacho-Díaz, Bernardo ^[3]; Arrieta, Oscar ^[4]

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1. Departamento de Radio-Oncologíam National Cancer Institute (INCan), México City (Mexico)
2. Thoracic Oncology Unit, National Cancer Institute (INCan), México City (Mexico)
3. Neuro-oncology Unit, National Cancer Institute (INCan), Mexico City (Mexico)
4. Thoracic Oncology Unit, National Cancer Institute - INCan, Mexico City (Mexico)

To this date, studies regarding the use of prophylactic cranial irradiation (PCI) versus standard of care (SoC) for patients with non-small cell lung cancer have shown limited benefit in survival outcomes, in addition to the potential effects on quality of life (QoL) and neurocognitive function (NCF). This randomized, phase II study evaluated the role of PCI in QoL and NCF, in a population comprised of subjects at a high risk for development of brain metastases (BM).

• OSTI ID: 23198760
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 1 Vol. 111; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
HEALTH HAZARDS
IRRADIATION
LUNGS
METASTASES
NEOPLASMS
PATIENTS
QUALITY OF LIFE