Prophylactic Cranial Irradiation Reduces Brain Metastases and Improves Overall Survival in High-Risk Metastatic Non-Small Cell Lung Cancer Patients: A Randomized phase 2 Study (PRoT-BM trial)

Journal Article · Sun Aug 15 04:00:00 EDT 2021 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/J.IJROBP.2021.02.044· OSTI ID:23198484

Arrieta, Oscar ^[1]; Maldonado, Federico ^[2]; Turcott, Jenny G.; Zatarain-Barrón, Zyanya Lucia; Barrón, Feliciano ^[1]; Blake-Cerda, Mónika ^[2]; Cabrera-Miranda, Luis Antonio ^[1]; Cardona, Andrés F. ^[3]; Garza, Jaime G. de la ^[1]; Rosell, Rafael ^[4]

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1. Thoracic Oncology Unit, National Cancer Institute, México City (Mexico)
2. Departamento de Radio-Oncología, National Cancer Institute, México City (Mexico)
3. Foundation for Clinical and Applied Cancer Research-FICMAC, Bogotá (Colombia)
4. Catalan Institute of Oncology, Germans Trias i Pujol Research Institute and Hospital Campus Can Ruti Barcelona (Spain)

To date, studies regarding the use of prophylactic cranial irradiation (PCI) versus standard of care (SoC) for patients with non-small cell lung cancer (NSCLC) have not shown a significant effect in terms of overall survival (OS). Additionally, the effect of PCI among high-risk patients has been scarcely studied. The objective of this randomized phase 2 study was to evaluate the role of PCI in a population of patients at high risk for development of brain metastases (BM).

• OSTI ID: 23198484
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 5 Vol. 110; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
DATES
HEALTH HAZARDS
IRRADIATION
LUNGS
METASTASES
NEOPLASMS
PATIENTS