Dietary Methionine Supplementation Exacerbates Gastrointestinal Toxicity in a Mouse Model of Abdominal Irradiation

Journal Article · Mon Feb 15 04:00:00 EST 2021 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/J.IJROBP.2020.09.042· OSTI ID:23198666

Ewing, Laura E. ^[1]; Skinner, Charles M. ^[1]; Pathak, Rupak ^[2]; Yee, Eric U. ^[3]; Krager, Kim ^[2]; Gurley, Patrick C. ^[1]; Melnyk, Stepan ^[4]; Boerma, Marjan ^[5]; Hauer-Jensen, Martin ^[2]; Koturbash, Igor ^[1]

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1. Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock (United States)
2. Division of Radiation Health, University of Arkansas for Medical Sciences, Little Rock (United States)
3. Department of Pathology, University of Arkansas for Medical Sciences, Little Rock (United States)
4. Arkansas Children’s Research Institute, Little Rock (United States)
5. Center for Dietary Supplements Research, University of Arkansas for Medical Sciences, Little Rock (United States)

Identification of appropriate dietary strategies for prevention of weight and muscle loss in cancer patients is crucial for successful treatment and prolonged patient survival. High-protein oral nutritional supplements decrease mortality and improve indices of nutritional status in cancer patients; however, high-protein diets are often rich in methionine, and experimental evidence indicates that a methionine-supplemented diet (MSD) exacerbates gastrointestinal toxicity after total body irradiation. Here, we sought to investigate whether MSD can exacerbate gastrointestinal toxicity after local abdominal irradiation, an exposure regimen more relevant to clinical settings.

• OSTI ID: 23198666
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 2 Vol. 109; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
METHIONINE
MICE
MORTALITY
MUSCLES
NEOPLASMS
PATIENTS
PROTEINS
TOXICITY
WHOLE-BODY IRRADIATION