Tumour suppressor properties of miR-15a and its regulatory effects on BCL2 and SOX2 proteins in colorectal carcinomas

Journal Article · Sat Sep 15 04:00:00 EDT 2018 · Experimental Cell Research

DOI:https://doi.org/10.1016/J.YEXCR.2018.06.025· OSTI ID:23082645

Gopalan, Vinod ^[1]; Ebrahimi, Faeza ^[1]; Islam, Farhadul ^[1]; Vider, Jelena ^[2]; Qallandar, Omel Baneen ^[1]; Pillai, Suja ^[1]; Lu, Cu-Tai ^[3]

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1. Cancer Molecular Pathology, School of Medicine, Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland (Australia)
2. School of Medical Science, Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland (Australia)
3. Department of Surgery, Gold Coast Hospital, Gold Coast, Queensland (Australia)

Highlights: • Downregulation of miR-15a was noted with colon cancer cell lines and patients with colorectal adenocarcinomas. • Expression levels of miR-15a was significantly altered with their matched metastatic lymph node tissues. • MiR-15 exhibits tumour suppressive properties in-vitro via controlling cell growth and mitochondrial respiration. • MiR-15a expresses its regulatory roles in cancer cell growth, apoptosis and stemness via BCL2 and SOX2 modulation. In this study, we aimed to investigate the expression pattern, clinicopathological significance and tumour suppressive properties of miR-15a in patients with colorectal carcinomas.

• OSTI ID: 23082645
• Journal Information: Experimental Cell Research, Journal Name: Experimental Cell Research Journal Issue: 2 Vol. 370; ISSN 0014-4827; ISSN ECREAL
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
APOPTOSIS
CARCINOGENESIS
CARCINOMAS
LARGE INTESTINE
LYMPH NODES
METASTASES
MITOCHONDRIA
PROTEINS
RESPIRATION