Histopathology and {sup 241}Am microdistribution in skeletal USTUR case 246

Journal Article · Fri Sep 01 00:00:00 EDT 1995 · Health Physics

DOI:https://doi.org/10.1097/00004032-199509000-00004· OSTI ID:229658

Priest, N D; Humphreys, J A.H. ^[1]; Freemont, A ^[2]; Kathren, R L ^[3]

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1. AEA Technology, Oxfordshire (United Kingdom)
2. Univ. of Manchester Medical School (United Kingdom)
3. Washington State Univ., Richland, WA (United States)

Histopathology and qualitative autoradiography studies were undertaken on bone removed at autopsy from USTUR Case 246. The histopathology examination revealed extensive bone marrow peritrabecular fibrosis and decreased cellularity in most samples. In addition, histological indicators suggest that bone cell turnover was suppressed at most sites, although turnover was found to be essentially normal in a vertebral body sample. The autoradiographic studies showed that bone turnover that had occurred resulted in the redistribution of americium within bone. However, surface deposits of americium remained conspicuous at many sites, particularly those with low bone growth activity. A few percent of the americium was present in the bone marrow. the dosimetric and toxicology findings indicate that current assumptions about the metabolic behavior of bone-seeking radionuclides are likely to be unrealistically simplistic. 15 refs., 9 figs.

• Sponsoring Organization: USDOE
• OSTI ID: 229658
• Journal Information: Health Physics, Vol. 69, Issue 3; Other Information: PBD: Sep 1995
• Country of Publication: United States
• Language: English

Related Subjects

56 BIOLOGY AND MEDICINE
APPLIED STUDIES
55 BIOLOGY AND MEDICINE
BASIC STUDIES
AMERICIUM 241
TISSUE DISTRIBUTION
INHALATION
SKIN ABSORPTION
MAN
RADIONUCLIDE KINETICS
HANFORD RESERVATION
RADIATION ACCIDENTS
BONE TISSUES
AUTORADIOGRAPHY
DOSIMETRY
BIOLOGICAL RADIATION EFFECTS
OCCUPATIONAL EXPOSURE
AUTOPSY
CONTAMINATION
ACUTE EXPOSURE
SKELETON
DOSE RATES
BONE MARROW
FIBROSIS
HISTOLOGY
PATHOLOGY