THE TOXICITY OF PLUTONIUM DEPOSITED IN SKELETAL TISSUES OF BEAGLES. I. THE RELATION OF THE DISTRIBUTION OF PLUTONIUM TO THE SEQUENCE OF HISTOPATHOLOGIC BONE CHANGES
The relation of the distribution of Pu to the sequence of histopathologic bone changes was studied using autoradiographic, microradiographic, histopathologic, and v ascular injection techniques. Dogs were sacrificed from 1 to 1576 days following a single intravenous administration of 2.7 mu c/kg of Pu/sup +4/ citrate given at 14 to 18 morths of age. Pu induced bone lesions by direct and indirect mechanisms. Early changes occurred in trabecular bone, resulting in a transverse plate in spongiosa, acellular marrow cavities, peritrabecular fibroses, abnormal bone resorption, and endosteal bone growth. Late changes affected cortical bone and were manliested by plugging of haversian canals, resulting in death of osteocytes, followed by disturbance in bone remodeling (large resorption cavities, bizarre-shaped and abnormally mineralized osteones), eroded periosteal surfaces, and fibroses and spontaneous fractures. The late effect was the induction of osteogenic sarcomas. (H.H.D.)
- Research Organization:
- Univ. of Utah, Salt Lake City
- NSA Number:
- NSA-17-010346
- OSTI ID:
- 4722843
- Journal Information:
- Laboratory Investigation (U.S.), Vol. Vol: 10; Other Information: Orig. Receipt Date: 31-DEC-63
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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