Mesenchymal Stem Cells from Mouse Adipose Tissue Stimulate Tumor Growth
Journal Article
·
· Bulletin of Experimental Biology and Medicine
- National Research Center Kurchatov Institute, Laboratory of Cell Biology and Molecular Medicine (Russian Federation)
We studied the effect of mesenchymal stem cells from the bone marrow and adipose tissue on the growth rate of melanoma B16 and mammary adenocarcinoma Ca755 tumors after their co-administration with tumor cells to syngeneic mice. Stimulation of tumor growth and formation of melanoma metastases in the lungs was found under the influence of adipose tissue-derived, but not bone marrow-derived stem cells. At delayed terms after irradiation in sublethal doses, the adipose tissue-derived mesenchymal stem cells also stimulated the tumor growth. Stimulation of the tumor growth by adipose tissue-derived mesenchymal stem cells was caused by factors secreted by these cells. Transplantation of mesenchymal stem cells to humans is possible only after accurate exclusion of malignant tumors.
- OSTI ID:
- 22927661
- Journal Information:
- Bulletin of Experimental Biology and Medicine, Journal Name: Bulletin of Experimental Biology and Medicine Journal Issue: 1 Vol. 167; ISSN BEXBAN; ISSN 0007-4888
- Country of Publication:
- United States
- Language:
- English
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