Cryochemical synthesis and antibacterial activity of hybrid nanocomposites based on dioxidine containing Ag and Cu nanoparticles incorporated in biopolymer cryostructurates
- M. V. Lomonosov Moscow State University, Department of Chemistry (Russian Federation)
- Russian Academy of Sciences, A. N. Nesmeyanov Institute of Organoelement Compound (Russian Federation)
- M. V. Lomonosov Moscow State University, Department of Biology (Russian Federation)
Cryochemical synthesis of hybrid nanocomposites based on the antibacterial drug, dioxidine, and metals (Ag, Cu) was performed. According to the data of H{sup 1} NMR, UV, and IR spectroscopy, low-temperature argon sorption, and transmission electron microscopy, met-als in these systems exist as Ag nanoparticles (with dimensions of 2—30 nm) or Cu nanoparti-cles (10—40 nm) involved in the bigger-sized particles of dioxidine with dimensions of 50—350 nm. These hybrid nanocomposites show the enhanced antibacterial activity towards the microbial cells Escherichia coli 52, Staphylococcus aureus 144, Mycobacterium cyaneum 98. The as-prepared drug nanocomposites are incorporated into spongy alginate cryostructurates. The feasibility of drug release from the biopolymer alginate carrier is proved and the related antibacterial activity is demonstrated.
- OSTI ID:
- 22863431
- Journal Information:
- Russian Chemical Bulletin, Vol. 66, Issue 11; Other Information: Copyright (c) 2017 Springer Science+Business Media, LLC, part of Springer Nature; Country of input: International Atomic Energy Agency (IAEA); ISSN 1066-5285
- Country of Publication:
- United States
- Language:
- English
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