Multicenter Prospective Clinical Series Evaluating Radiofrequency Ablation in the Treatment of Painful Spine Metastases

Journal Article · Thu Sep 15 04:00:00 EDT 2016 · Cardiovascular and Interventional Radiology

DOI:https://doi.org/10.1007/S00270-016-1400-8· OSTI ID:22645451

Bagla, Sandeep ^[1]; Sayed, Dawood ^[2]; Smirniotopoulos, John ^[3]; Brower, Jayson ^[4]; Neal Rutledge, J. ^[5]; Dick, Bradley ^[6]; Carlisle, James ^[7]; Lekht, Ilya ^[8]; Georgy, Bassem ^[9]

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1. Vascular Institute of Virginia, LLC (United States)
2. University of Kansas Medical Center (United States)
3. New York Presbyterian Hospital/Weill Cornell Medical Center (United States)
4. Providence Sacred Heart Medical Center and Children’s Hospital (United States)
5. Seton Medical Center (United States)
6. Suburban Hospital (United States)
7. St. Mark’s Hospital (United States)
8. University of Southern California (United States)
9. San Diego Imaging (United States)

BackgroundRadiofrequency ablation (RFA) of vertebral body metastases (VBM) has been reported as safe and effective in retrospective studies. This single-arm prospective multicenter clinical study evaluates RFA in the treatment of painful VBM.MethodsFifty patients with VBM were prospectively enrolled during a 13-month period at eight US centers under an IRB-approved study. Percutaneous RFA was performed under imaging guidance with cement augmentation at the discretion of the operator. Pain, disability and quality of life were evaluated at baseline, prior to discharge, days 3, 7, 30 and 90 using the Numerical Pain Rating Scale, Oswestry Disability Index (ODI), the Functional Assessment of Cancer Therapy-General 7 (FACT-G7) and Functional Assessment of Cancer Therapy Quality-of-Life Measurement in Patients with Bone Pain (FACT-BP). Adverse events were monitored throughout this time interval.ResultsTwenty-six male and 24 female patients (mean age 61.0) underwent 69 treatments (30 thoracic and 39 lumbar). Cement augmentation was performed in 96 % of reported levels. Significant improvement in mean scores for pain, disability and cancer-specific health-related quality of life from baseline to all time intervals was seen. NRPS improved from 5.9 to 2.1 (p < 0.0001). ODI improved from 52.9 to 37.0 (p < 0.08). FACT-G7 improved form 10.9 to 16.2 (p = 0.0001). FACT-BP improved from 22.6 to 38.9 (p < 0.001). No complications related to the procedure were reported.ConclusionRFA with cement augmentation safely and effectively reduces pain and disability rapidly, while increasing quality of life in patients suffering from vertebral body metastases.

• OSTI ID: 22645451
• Journal Information: Cardiovascular and Interventional Radiology, Journal Name: Cardiovascular and Interventional Radiology Journal Issue: 9 Vol. 39; ISSN 0174-1551; ISSN CAIRDG
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ABLATION
AUGMENTATION
BIOMEDICAL RADIOGRAPHY
BORON PHOSPHIDES
CEMENTS
METASTASES
NEOPLASMS
PAIN
PATIENTS
RADIOWAVE RADIATION
THERAPY
VERTEBRAE