Percutaneous Vertebroplasty in Multiple Myeloma: Prospective Long-Term Follow-Up in 106 Consecutive Patients

Journal Article · Wed Feb 15 00:00:00 EST 2012 · Cardiovascular and Interventional Radiology

DOI:https://doi.org/10.1007/S00270-011-0111-4· OSTI ID:21608634

Manca, Antonio ^[1]; Montemurro, Filippo ^[2]; Hirsch, Joshua ^[3]; Chiara, Gabriele ^[1]; Grignani, Giovanni; Capaldi, Antonio; Sardo, Elena; Debernardi, Felicino ^[4]; Iussich, Gabriella ^[1]; Regge, Daniele ^[5]

---

1. Institute for Cancer Research and Treatment, Interventional Radiology Unit (Italy)
2. Institute for Cancer Research and Treatment, Oncology Unit (Italy)
3. Massachusetts General Hospital, Interventional Neuroradiology (United States)
4. Institute for Cancer Research and Treatment, Anesthesiology Unit (Italy)
5. Institute for Cancer Research and Treatment, Radiology Unit (Italy)

Purpose: Percutaneous vertebroplasty (PV) is a minimally invasive procedure involving the injection of bone cement within a collapsed vertebral body. Although this procedure was demonstrated to be effective in osteoporosis and metastases, few studies have been reported in cases of multiple myeloma (MM). We prospectively evaluated the safety and efficacy of PV in the treatment of vertebral compression fractures (VCFs) resulting from MM. Materials and Methods: PV was performed in 106 consecutive MM patients who had back pain due to VCFs, the treatment of which had failed conservative therapies. Follow-up (28.2 {+-} 12.1 months) was evaluated at 7 and 15 days as well as at 1, 3, 6, 12, 18, and every 6 months after PV. Visual analog scale (VAS) pain score, opioid use, external brace support, and Oswestry Disability Index (ODI) score were recorded. Results: The median pretreatment VAS score of 9 (range 4-10) significantly (P < 0.001) decreased to 1 (range 0-9) after PV. Median pre-ODI values of 82% (range 36-89%) significantly improved to 7% (range 0-82%) (P < 0.001). Differences in pretreatment and posttreatment use of analgesic drug were statistically significant (P < 0.001). The majority of patients (70 of 81; 86%) did not use an external brace after PV (P < 0.001). Conclusion: PV is a safe, effective, and long-lasting procedure for the treatment of vertebral compression pain resulting from MM.

• OSTI ID: 21608634
• Journal Information: Cardiovascular and Interventional Radiology, Vol. 35, Issue 1; Other Information: DOI: 10.1007/s00270-011-0111-4; Copyright (c) 2012 Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); Country of input: International Atomic Energy Agency (IAEA); ISSN 0174-1551
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ANALGESICS
CEMENTS
FRACTURES
INJECTION
METASTASES
OSTEOPOROSIS
PAIN
PATIENTS
SAFETY
SKELETON
THERAPY
BODY
BUILDING MATERIALS
CENTRAL NERVOUS SYSTEM AGENTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DISEASES
DRUGS
FAILURES
INTAKE
MATERIALS
MEDICINE
ORGANS
SKELETAL DISEASES
SYMPTOMS