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Single-Session CT-Guided Percutaneous Microwave Ablation of Bilateral Adrenal Gland Hyperplasia Due to Ectopic ACTH Syndrome

Journal Article · · Cardiovascular and Interventional Radiology
;  [1];  [2];  [3];  [4]; ;  [5];  [3]
  1. University of Manitoba, Department of Radiology (Canada)
  2. Brigham and Women’s Hospital, Department of Anesthesiology (United States)
  3. Brigham and Women’s Hospital, Department of Radiology (United States)
  4. Dana Farber Cancer Institute, Department of Medicine (United States)
  5. Brigham and Women’s Hospital, Department of Endocrinology (United States)
+ Show Author Affiliations

Bilateral adrenalectomy is currently the only available treatment for adrenocorticotropic hormone (ACTH)-dependent Cushing’s syndrome (ectopic ACTH syndrome) that is refractory to pharmacologic therapy. We describe two patients with refractory ectopic ACTH syndrome who were treated with CT-guided percutaneous microwave ablation of both hyperplastic adrenal glands in a single session: One was not a surgical candidate, and the other had undergone unsuccessful surgery. Following the procedure, both patients achieved substantial decreases in serum cortisol, symptomatic improvement, and decreased anti-hypertensive medication requirements.

OSTI ID:
22469771
Journal Information:
Cardiovascular and Interventional Radiology, Journal Name: Cardiovascular and Interventional Radiology Journal Issue: 5 Vol. 38; ISSN 0174-1551; ISSN CAIRDG
Country of Publication:
United States
Language:
English

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Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ABLATION
ACTH
ADRENAL GLANDS
ADRENALECTOMY
COMPUTERIZED TOMOGRAPHY
CURRENTS
HYDROCORTISONE
MICROWAVE RADIATION
PATIENTS
REFRACTORIES
THERAPY
WHO