Visualisation of distribution of gold nanoparticles in liver tissues ex vivo and in vitro using the method of optical coherence tomography

Journal Article · Sat Jun 30 04:00:00 EDT 2012 · Quantum Electronics (Woodbury, N.Y.)

DOI:https://doi.org/10.1070/QE2012V042N06ABEH014884· OSTI ID:22043938

Genina, Elina A; Terentyuk, G S; Khlebtsov, B N; Bashkatov, A N; Tuchin, Valerii V

The possibility of visualising the distribution of gold nanoparticles in liver by means of the method of optical coherence tomography is studied experimentally in model samples of beef liver in vitro and rat liver ex vivo. In the experiments we used the gold nanoparticles in the form of nanocages with resonance absorption in the near-IR spectral region. In the model studies the suspension of nanoparticles was applied to the surface of the sample, which then was treated with ultrasound. In the ex vivo studies the suspension of nanoparticles was injected to the laboratory rats intravenously. The image contrast and the optical depth of detection of blood vessels and liver structure components are calculated, as well as the depth of liver optical probing before and after the injection of nanoparticles. It was shown that the administration of the nanoparticle increases significantly the imaging contrast of liver blood vessels owing to the localisation of the nanoparticles therein.

• OSTI ID: 22043938
• Journal Information: Quantum Electronics (Woodbury, N.Y.), Journal Name: Quantum Electronics (Woodbury, N.Y.) Journal Issue: 6 Vol. 42; ISSN 1063-7818
• Country of Publication: United States
• Language: English

Related Subjects

71 CLASSICAL AND QUANTUM MECHANICS
GENERAL PHYSICS
BIOPHYSICS
BLOOD VESSELS
DISTRIBUTION
GOLD
IMAGES
IN VITRO
INJECTION
LIVER
MEAT
NANOSTRUCTURES
PARTICLES
RESONANCE ABSORPTION
SURFACES
SUSPENSIONS
TOMOGRAPHY