Use of fractional laser microablation and ultrasound to facilitate the delivery of gold nanoparticles into skin in vivo

Journal Article · Sat Jun 30 04:00:00 EDT 2012 · Quantum Electronics (Woodbury, N.Y.)

DOI:https://doi.org/10.1070/QE2012V042N06ABEH014882· OSTI ID:22043937

Terentyuk, G S; Genina, Elina A; Bashkatov, A N; Ryzhova, M V; Tsyganova, N A; Chumakov, D S; Khlebtsov, B N; Sazonov, A A; Dolotov, L E; Tuchin, Valerii V; Khlebtsov, Nikolai G; Inozemtseva, O A

The delivery of gold nanoparticles (nanocages coated with a layer of silicon dioxide (40/20 nm)) dispersed in the solution (glycerol + polyethylene glycol-400, 1 : 1) into the skin tissue is studied experimentally in vivo. From the data of optical coherence tomography and histochemical analysis it follows that simple application of suspension of nanoparticles is not efficient enough for delivery of the particles into the skin as a result of passive diffusion. It is shown that fractional laser microablation of skin before the application of the suspension, followed by the topical treatment by ultrasound allows penetration through the epidermis layer and delivery of nanoparticles into dermis and hypodermis.

• OSTI ID: 22043937
• Journal Information: Quantum Electronics (Woodbury, N.Y.), Journal Name: Quantum Electronics (Woodbury, N.Y.) Journal Issue: 6 Vol. 42; ISSN 1063-7818
• Country of Publication: United States
• Language: English

Related Subjects

77 NANOSCIENCE AND NANOTECHNOLOGY
BIOPHYSICS
DELIVERY
DIFFUSION
EPIDERMIS
GLYCEROL
GOLD
IN VIVO
LASER RADIATION
LAYERS
NANOSTRUCTURES
PARTICLES
POLYETHYLENE GLYCOLS
SILICON OXIDES
SUSPENSIONS
TOMOGRAPHY