THE EFFECT OF BONE MARROW IRRADIATED IN VIVO AND IN VITRO ON THE LIVER REGENERATION OF RATS
Partially hepatectomized rats were exposed to wholebody irradiation of 100 to 1000 r. A suspension of in vivo irradiated bone marrow was prepared from the femurs and tibias of some of the exposed rats. A suspension was also prepared from bone marrow taken from unexposed animals and irradiated in a test tube. The suspensions were injected into the bones of healthy animals and their effects studied. A considerable decrease was observed in the liver regeneration in rats exposed to whole-body irradiation, although their liver region was protected by sheet lead; this is attributed to bone marrow irradiation. Irradiation of bone marrow or injection into the bones of healthy animals of a suspension of in vivo irradiated bone marrow inhibits the liver regeneration in proportion with the dose of exposure. Injection of in vitro irradiated bone marrow suspension stimulated regeneration provided that the doses did not exceed 400 r but had an inhibitory effect if the dose was above 400 r. (OTS)
- Research Organization:
- Originating Research Org. not identified
- NSA Number:
- NSA-17-019859
- OSTI ID:
- 4733345
- Journal Information:
- Magyar Radiologia (Hungary), Journal Name: Magyar Radiologia (Hungary) Vol. Vol: No. 5; ISSN MARAA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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