Synthesis and release behavior of composites of camptothecin and layered double hydroxide

Journal Article · Sun Aug 15 04:00:00 EDT 2010 · Journal of Solid State Chemistry

DOI:https://doi.org/10.1016/j.jssc.2010.05.035· OSTI ID:21483662

Lun, Dong ^[1]; Li, Yan ^[2]; Shaojie, Liu ^[2]

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1. School of Medicine, Shandong University, Jinan 250100 (China)
2. Key Laboratory for Colloid and Interface Chemistry of Education Ministry, Shandong University, Jinan 250100 (China)

A simple method, reconstruction of calcinated layered double hydroxides (CLDH) in an organic (ethanol)-water mixed solvent medium containing drug, was developed to intercalate partially a non-ionic and poorly water-soluble drug (camptothecin) into the gallery of layered double hydroxides (LDHs) to form the drug-LDH composites. The purpose of choosing organic-water mixed solvent is to increase remarkably the solubility of camptothecin (CPT) in the reconstruction medium. A probable morphology of CPT molecules in the gallery of LDHs is that CPT molecules arrange as monolayer with the long axis parallel to the LDH layers. The in vitro drug release from the composites was remarkably lower than that from the corresponding physical mixture, which shows these drug-inorganic composites can be used as a potential drug delivery system. - Graphical abstract: A simple method, reconstruction of calcinated LDHs in an organic-water medium containing drug, was developed to intercalate non-ionic and poorly water-soluble camptothecin into the gallery of LDHs.

• OSTI ID: 21483662
• Journal Information: Journal of Solid State Chemistry, Journal Name: Journal of Solid State Chemistry Journal Issue: 8 Vol. 183; ISSN 0022-4596; ISSN JSSCBI
• Country of Publication: United States
• Language: English

Related Subjects

36 MATERIALS SCIENCE
ALCOHOLS
CARRIERS
CLATHRATES
DISPERSIONS
DRUGS
ETHANOL
HYDROGEN COMPOUNDS
HYDROXIDES
HYDROXY COMPOUNDS
LAYERS
MIXED SOLVENTS
MIXTURES
MORPHOLOGY
ORGANIC COMPOUNDS
OXYGEN COMPOUNDS
SOLUBILITY
SOLVENTS
SYNTHESIS
WATER