Solubility and release of fenbufen intercalated in Mg, Al and Mg, Al, Fe layered double hydroxides (LDH): The effect of Eudragit S 100 covering

Journal Article · Tue Dec 14 23:00:00 EST 2010 · Journal of Solid State Chemistry

DOI:https://doi.org/10.1016/j.jssc.2010.10.017· OSTI ID:21504032

Arco, M del; Fernandez, A; Martin, C ^[1]; Rives, V ^[1]

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1. GIR-QUESCAT, Departamento de Quimica Inorganica, Universidad de Salamanca, 37008 Salamanca (Spain)

Following different preparation routes, fenbufen has been intercalated in the interlayer space of layered double hydroxides with Mg{sup 2+} and Al{sup 3+} or Mg{sup 2+}, Al{sup 3+} and Fe{sup 3+} in the layers. Well crystallized samples were obtained in most of the cases (intercalation was not observed by reconstruction of the MgAlFe matrix), with layer heights ranging between 16.1 and 18.8 A. The presence of the LDH increases the solubility of fenbufen, especially when used as a matrix. The dissolution rate of the drug decreases when the drug is intercalated, and is even lower in those systems containing iron; release takes place through ionic exchange with phosphate anions from the solution. Preparation of microspheres with Eudragit S 100 leads to solids with an homogeneous, smooth surface with efficient covering of the LDH surface, as drug release was not observed at pH lower than 7. - Graphical abstract: LDHs containing Mg, Al, Fe increase fenbufen solubility, release takes place through ionic exchange with phosphate anions from the medium. Spherical solids with homogeneous, smooth surface are formed when using Eudragit S 100, efficiently covering the LDH surface. Display Omitted

• OSTI ID: 21504032
• Journal Information: Journal of Solid State Chemistry, Journal Name: Journal of Solid State Chemistry Journal Issue: 12 Vol. 183; ISSN 0022-4596; ISSN JSSCBI
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
ALKALINE EARTH METAL COMPOUNDS
ALUMINIUM COMPOUNDS
ALUMINIUM HYDROXIDES
ALUMINIUM IONS
CHARGED PARTICLES
CLATHRATES
DISSOLUTION
DRUGS
HYDROGEN COMPOUNDS
HYDROXIDES
ION EXCHANGE
IONS
IRON COMPOUNDS
IRON HYDROXIDES
IRON IONS
LAYERS
MAGNESIUM COMPOUNDS
MAGNESIUM HYDROXIDES
MAGNESIUM IONS
MICROSPHERES
OXYGEN COMPOUNDS
PH VALUE
PHOSPHATES
PHOSPHORUS COMPOUNDS
SOLUBILITY
TRANSITION ELEMENT COMPOUNDS