Synthesis and characterization of 5-fluorocytosine intercalated Zn-Al layered double hydroxide

Journal Article · Fri Aug 15 04:00:00 EDT 2008 · Journal of Solid State Chemistry

OSTI ID:21128375

Chunxia, Liu ^[1]; Wanguo, Hou ^[1]; Lifang, Li ^[2]; Yan, Li; Shaojie, Liu ^[1]

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1. Key Laboratory for Colloid and Interface Chemistry of Education Ministry, Shandong University, Jinan 250100 (China)
2. College of Chemistry and Material Science, Shandong Agriculture University, Taian 271018 (China)

In this paper, the intercalation of 5-fluorocytosine (5-FC) into a layered inorganic host, Zn-Al layered double hydroxide (LDH), has been carried out using coprecipitation method to obtain 5-FC/LDH nanohybrids. The intercalated amount (A{sub In}) of 5-FC into the LDH is remarkably dependent on the molar ratio (R{sub F/M}) of 5-FC to metal ions and the pH of coprecipitation system. The morphology of 5-FC molecules in 5-FC/LDH nanohybrids is dependent on the A{sub In}. It is interestingly found that the morphology of the nanohybrid particles may be changed with the increase of R{sub F/M} from hexagonal plate particles to threadlike particles. The in vitro drug release from the nanohybrids is remarkably lower than that from the corresponding physical mixture and pristine 5-FC at either pH 4.8 or pH 7.5. In addition, the release rate of 5-FC from the nanohybrid at pH 7.5 is remarkably lower than that at pH 4.8, this is due to a possible difference in the release mechanism. The obtained results show these drug-inorganic nanohybrids can be used as a potential drug delivery system. - Graphical abstract: The 5-fluorocytosine (5-FC) has been intercalated into layered double hydroxide using coprecipitation method. The morphology of 5-FC molecules in obtained nanohybrids was dependent on the intercalated amount of 5-FC. The in vitro drug release from the nanohybrids was remarkably lower than that from the corresponding physical mixture, which shows these drug-inorganic nanohybrids can be used as a potential drug delivery system.

• OSTI ID: 21128375
• Journal Information: Journal of Solid State Chemistry, Journal Name: Journal of Solid State Chemistry Journal Issue: 8 Vol. 181; ISSN 0022-4596; ISSN JSSCBI
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
ALUMINIUM HYDROXIDES
CARRIERS
COPRECIPITATION
CYTOSINE
DELIVERY
DRUGS
IN VITRO
MORPHOLOGY
ORGANIC FLUORINE COMPOUNDS
SYNTHESIS
ZINC HYDROXIDES