Methotrexate intercalated ZnAl-layered double hydroxide

Journal Article · Thu Sep 15 04:00:00 EDT 2011 · Journal of Solid State Chemistry

DOI:https://doi.org/10.1016/j.jssc.2011.07.015· OSTI ID:21580269

Chakraborty, Manjusha; Dasgupta, Sudip; Soundrapandian, Chidambaram ^[1]; Chakraborty, Jui ^[1]; Ghosh, Swapankumar ^[2]; Mitra, Manoj K ^[3]; Basu, Debabrata ^[1]

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1. Central Glass and Ceramic Research Institute, CSIR, 196 Raja S.C. Mullick Road, Kolkata 700032 (India)
2. National Institute for Interdisciplinary Science and Technology (NIIST), CSIR, Trivandrum 695019 (India)
3. Department of Metallurgical and Materials Engineering, Jadavpur University, Kolkata 700032 (India)

The anticancerous drug methotrexate (MTX) has been intercalated into an ZnAl-layered double hydroxide (LDH) using an anion exchange technique to produce LDH-MTX hybrids having particle sizes in the range of 100-300 nm. X-ray diffraction studies revealed increases in the basal spacings of ZnAl-LDH-MTX hybrid on MTX intercalation. This was corroborated by the transmission electron micrographs, which showed an increase in average interlayer spacing from 8.9 A in pristine LDH to 21.3 A in LDH-MTX hybrid. Thermogravimetric analyses showed an increase in the decomposition temperature for the MTX molecule in the LDH-MTX hybrid indicating enhanced thermal stability of the drug molecule in the LDH nanovehicle. The cumulative release profile of MTX from ZnAl-LDH-MTX hybrids in phosphate buffer saline (PBS) at pH 7.4 was successfully sustained for 48 h following Rigter-Peppas model release kinetics via diffusion. - Graphical abstract: ZnAl-layered double hydroxide intercalated with methotrexate ({approx}34% loading) promises the possibility of use of ZnAl-LDH material as drug carrier and in controlled delivery. Highlights: > ZnAl-layered double hydroxide methotrexate nanohybrid has been synthesized. > XRD and TEM studies on nanohybrid revealed successful intercalation of methotrexate. > TG and CHN analyses showed {approx}34 wt% of methotrexate loading into the nanohybrid. > Possibility of use of ZnAl-LDH material as drug carrier and in delivery.

• OSTI ID: 21580269
• Journal Information: Journal of Solid State Chemistry, Journal Name: Journal of Solid State Chemistry Journal Issue: 9 Vol. 184; ISSN 0022-4596; ISSN JSSCBI
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
ANTIMETABOLITES
CHEMICAL ANALYSIS
COHERENT SCATTERING
DIFFRACTION
DRUGS
ELECTRON MICROSCOPY
GRAVIMETRIC ANALYSIS
HYBRIDIZATION
HYDROGEN COMPOUNDS
HYDROXIDES
ION EXCHANGE
METHOTREXATE
MICROSCOPY
OXYGEN COMPOUNDS
PARTICLE SIZE
QUANTITATIVE CHEMICAL ANALYSIS
SCATTERING
SIZE
THERMAL ANALYSIS
THERMAL GRAVIMETRIC ANALYSIS
TRANSMISSION ELECTRON MICROSCOPY
X-RAY DIFFRACTION