In vivo infection of IgG-containing cells by Jembrana disease virus during acute infection

Journal Article · Sun Oct 25 00:00:00 EDT 2009 · Virology

DOI:https://doi.org/10.1016/j.virol.2009.07.027· OSTI ID:21357557

Desport, Moira ^[1]; Tenaya, I.W. Masa ^[1]; McLachlan, Alexander; McNab, Tegan J; Rachmat, Judhi ^[1]; Hartaningsih, Nining ^[2]; Wilcox, Graham E ^[1]

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1. School of Veterinary and Biomedical Science, Murdoch University, Murdoch WA 6150 (Australia)
2. Disease Investigation Centre, PO Box 3322, Denpasar, Bali (Indonesia)

Jembrana disease virus (JDV) is an unusual bovine lentivirus which causes a non-follicular proliferation of lymphocytes, a transient immunosuppression and a delayed humoral response in infected Bali cattle in Indonesia. A double-immunofluorescent labeling method was developed to identify the subset of mononuclear cells in which the viral capsid protein could be detected. Viral antigen was present in pleomorphic centroblast-like cells which were identified as IgG-containing cells, including plasma cells, in lymphoid tissues. There was no evidence of infection of CD3{sup +} T-cells or MAC387{sup +} monocytes in tissues but large vacuolated cells with a macrophage-like morphology in the lung were found to contain viral antigen although they could not be shown conclusively to be infected. The tropism of JDV for mature IgG-containing cells may be relevant to understanding the pathogenesis of Jembrana disease, the delayed antibody responses and the genetic composition of this atypical lentivirus.

• OSTI ID: 21357557
• Journal Information: Virology, Vol. 393, Issue 2; Other Information: DOI: 10.1016/j.virol.2009.07.027; PII: S0042-6822(09)00458-9; Copyright (c) 2009 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; ISSN 0042-6822
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
ANTIGENS
CATTLE
DISEASES
IMMUNOGLOBULINS
IMMUNOSUPPRESSION
IN VIVO
LUNGS
LYMPHOCYTES
MACROPHAGES
PATHOGENESIS
PLASMA CELLS
PROLIFERATION
VIRUSES
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DOMESTIC ANIMALS
GLOBULINS
LEUKOCYTES
MAMMALS
MATERIALS
MICROORGANISMS
ORGANIC COMPOUNDS
ORGANS
PARASITES
PHAGOCYTES
PROTEINS
RESPIRATORY SYSTEM
RUMINANTS
SOMATIC CELLS
VERTEBRATES