Glionitrin A, an antibiotic-antitumor metabolite derived from competitive interaction between abandoned mine microbes
Journal Article
·
· Journal of Natural Products
- Korean Institute of Science & Technology KIST, Kangnung (Republic of Korea)
The nutrient conditions present in abandoned coal mine drainages create an extreme environment where defensive and offensive microbial interactions could be critical for survival and fitness. Coculture of a mine drainage-derived Sphingomonas bacterial strain, KMK-001, and a mine drainage-derived Aspergillus fumigatus fungal strain, KMC-901, resulted in isolation of a new diketopiperazine disulfide, glionitrin A (1). Compound 1 was not detected in monoculture broths of KMK-001 or KMC-901. The structure of 1, a (3S,10aS) diketopiperazine disulfide containing a nitro aromatic ring, was based on analysis of MS, NMR, and circular dichroism spectra and confirmed by X-ray crystal data. Glionitrin A displayed significant antibiotic activity against a series of microbes including methicillin-resistant Staphylococcus aureus. An in vitro MTT cytotoxicity assay revealed that 1 had potent submicromolar cytotoxic activity against four human cancer cell lines: HCT-116, A549, AGS, and DU145. The results provide further evidence that microbial coculture can produce novel biologically relevant molecules.
- OSTI ID:
- 21162076
- Journal Information:
- Journal of Natural Products, Journal Name: Journal of Natural Products Journal Issue: 2 Vol. 72; ISSN 0163-3864
- Country of Publication:
- United States
- Language:
- English
Similar Records
Synthesis and cytotoxicity of novel dispiro derivatives of 5-arylidenoxazolones, potential inhibitors of p53—MDM2 protein-protein interaction
Synthesis of dehydro-α-lapachones, α- and β-lapachones, and screening against cancer cell lines
Antiproliferative activity of ursolic acid/glycyrrhetinic acid-uracil/thymine hybrids
Journal Article
·
Thu Mar 15 00:00:00 EDT 2018
· Russian Chemical Bulletin
·
OSTI ID:22863354
Synthesis of dehydro-α-lapachones, α- and β-lapachones, and screening against cancer cell lines
Journal Article
·
Sat Dec 14 23:00:00 EST 2019
· Medicinal Chemistry Research (Print)
·
OSTI ID:22936157
Antiproliferative activity of ursolic acid/glycyrrhetinic acid-uracil/thymine hybrids
Journal Article
·
Sat Jun 01 00:00:00 EDT 2019
· Medicinal Chemistry Research (Print)
·
OSTI ID:22936190