Antiproliferative activity of ursolic acid/glycyrrhetinic acid-uracil/thymine hybrids
Journal Article
·
· Medicinal Chemistry Research (Print)
- State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy of Guangxi Normal University (China)
As pharmacophore hybridization has been used frequently in the discovery of new drugs, ursolic acid/glycyrrhetinic acid-uracil/thymine hybrids have been synthesized and evaluated their antiproliferative activity by the MTT assay. The results displayed that, the hybrids of glycyrrhetinic acid (7a–7b to 10a–10b) exhibited slightly better antiproliferative activity than that of ursolic acid hybrids (3a–3b to 6a–6b). Two single glycyrrhetinic acid-thymine hybrids (8a and 10a) possessed good antiproliferative activity against tested A549 cell line (IC{sub 50} = 10.7 and 18.3 µM, respectively). And three hybrids (3a, 5a, and 10b) exhibited about 80% inhibitory ratio against tested Hela cell line.
- OSTI ID:
- 22936190
- Journal Information:
- Medicinal Chemistry Research (Print), Journal Name: Medicinal Chemistry Research (Print) Journal Issue: 6 Vol. 28; ISSN 1054-2523
- Country of Publication:
- United States
- Language:
- English
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