Synthesis of dehydro-α-lapachones, α- and β-lapachones, and screening against cancer cell lines
Journal Article
·
· Medicinal Chemistry Research (Print)
- Universidade Federal Fluminense, Instituto de Química, Campus do Valonguinho (Brazil)
- Universidade Federal Fluminense, Faculdade de Farmácia (Brazil)
- Universidade Federal do Ceará, Centro de Ciências da Saúde, Núcleo de Pesquisa e Desenvolvimento de Medicamentos (Brazil)
14 new naphthoquinones were prepared and tested against human cancer cell lines PC-3 (prostate), HCT-116 (colon carcinoma), SNB-19 (glioblastoma), HL-60 (leukemia) and MCF-7 (breast), and a nontumor cell line L929 (murine fibroblasts) to determine cytotoxicity with the MTT assay. 8-OH-β-lapachones (14a, 14c, 14d) presented best results, showing low IC{sub 50} values and high selectivity for HCT-116 and HL-60 tumor cells.
- OSTI ID:
- 22936157
- Journal Information:
- Medicinal Chemistry Research (Print), Journal Name: Medicinal Chemistry Research (Print) Journal Issue: 12 Vol. 28; ISSN 1054-2523
- Country of Publication:
- United States
- Language:
- English
Similar Records
The Effect of Folic Acid- and Caffeic Acid-Functionalized SPION on Different Cancer Cell Lines
A flexible cold microplasma jet using biocompatible dielectric tubes for cancer therapy
Curcumin differentially affects cell cycle and cell death in acute and chronic myeloid leukemia cells
Journal Article
·
Wed Nov 14 23:00:00 EST 2018
· Journal of Superconductivity and Novel Magnetism
·
OSTI ID:22773659
A flexible cold microplasma jet using biocompatible dielectric tubes for cancer therapy
Journal Article
·
Mon May 17 00:00:00 EDT 2010
· Applied Physics Letters
·
OSTI ID:21347451
Curcumin differentially affects cell cycle and cell death in acute and chronic myeloid leukemia cells
Journal Article
·
Thu Feb 22 19:00:00 EST 2018
· Oncology Letters
·
OSTI ID:1880958