Post-stenting Intravascular Brachytherapy Trials on Hypercholesterolemic Rabbits Using 32P Liquid Sources: Implications for Prevention of In-Stent Restenosis

Journal Article · Thu Aug 15 04:00:00 EDT 2002 · Cardiovascular and Interventional Radiology

DOI:https://doi.org/10.1007/S00270-002-1879-Z· OSTI ID:21083425

Wilczek, Krzysztof ^[1]; Walichiewicz, Piotr ^[2]; Petelenz, Barbara ^[3]; Jachec, Wojciech; Jochem, Jerzy; Tomasik, Andrzej ^[4]; Bilski, Pawel ^[3]; Snietura, Miroslaw ^[2]; Wodniecki, Jan ^[4]

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1. III rd Department of Cardiology, Silesian School of Medicine, 2 Szpitalna str., 41-800 Zabrze (Poland)
2. Institute of Oncology, Gliwice (Poland)
3. Institute of Nuclear Physics, Cracow (Poland)
4. II nd Department of Cardiology, Silesian School of Medicine, Zabrze (Poland)

Purpose: Liquid sources of radiation delivered in angioplasty balloons may be a convenient self-centering device used for prevention of in-stent restenosis. To test the effectiveness of this method an intravascular brachytherapy study was performed using 32P liquid sources in an animal model. Methods: The radial dose distribution around angioplasty balloons filled with solutions of Na2H32PO4 was calibrated by thermoluminescence dosimetry. The animal experiments were performed in rabbits with induced hypercholesterolemia. The balloons containing 32P were introduced into iliac arteries immediately after stent implantation. Estimated 7-49 Gy doses required 30-100 minirradiations. Radiation effects were evaluated by comparing the thickness of various components of the artery wall. Results:Doses of 7, 12, 16 or 49 Gy on the internal artery surface required 30-100 min of irradiation. The dose of 49 Gy at 'zero' distance corresponding to 16 Gy at 1.0 mm from the balloon surface reduced hypertrophy in every layer of the arterial wall: in the intima the cross-sectional areas were 0.13 versus 0.91 mm2, in the media were 0.5 versus 0.46 mm2 and in the adventitia were 0.04 versus 0.3 mm2 (p <0.05). A dose of 7 Gyat the balloon surface produced adverse irradiation effects: the intimal area of the artery was 2.087 versus 0.857 mm2, the medial area was 0.59 versus 0.282 mm2 and the adventitial area was 0.033 versus 0.209 mm2 in treated and control arteries, respectively.Conclusion: Application of a 49 Gy irradiation dose to the internal arterial surface effectively prevented in-stentrestenosis.

• OSTI ID: 21083425
• Journal Information: Cardiovascular and Interventional Radiology, Journal Name: Cardiovascular and Interventional Radiology Journal Issue: 4 Vol. 25; ISSN 0174-1551; ISSN CAIRDG
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ARTERIES
BRACHYTHERAPY
IRRADIATION
RABBITS
RADIATION DOSE DISTRIBUTIONS
RADIATION EFFECTS
THERMOLUMINESCENT DOSIMETRY
THICKNESS