Post-Dilatation Intravascular Brachytherapy Trials on Hypercholesterolemic Rabbits Using {sup 32}P-Phosphate Solutions in Angioplasty Balloons

Journal Article · Thu Jan 15 04:00:00 EST 2004 · Cardiovascular and Interventional Radiology

DOI:https://doi.org/10.1007/S00270-003-2700-3· OSTI ID:21088315

Walichiewicz, Piotr ^[1]; Wilczek, Krzysztof ^[2]; Petelenz, Barbara ^[3]; Jachec, Wojciech; Jochem, Jerzy; Tomasik, Andrzej ^[4]; Bilski, Pawel ^[5]; Gaca, Pawel ^[3]; Banaszczuk, Joanna ^[6]; Ihnatowicz, Jerzy ^[7]; Wodniecki, Jan ^[4]

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1. Institute of Oncology-Gliwice Division, 44-101 Gliwice, Brachytherapy Unit (Poland)
2. Medical University of Silesia, 41-800 Zabrze, IIIrd Department of Cardiology (Poland)
3. Institute of Nuclear Physics, 31-342 Krakow, Department of Nuclear Physical Chemistry (Poland)
4. Medical University of Silesia, 41-800 Zabrze, IInd Department of Cardiology (Poland)
5. Institute of Nuclear Physics, 31-342 Krakow, Health Physics Laboratory (Poland)
6. University of Mining and Metallurgy, 30-059 Krakow, Faculty of Physics and Nuclear Techniques (Poland)
7. Electronics and Informatics, Silesian Technical University, 44-100 Gliwice, Department of Automatic Control (Poland)

Response of peripheral arteries to post-dilatation intravascular brachytherapy (IVBT) using {sup 32}P liquid sources was studied in a rabbit model. The applied sources were angioplasty balloons filled with aqueous solutions of Na{sub 2}H{sup 32}PO{sub 4}, NaCl and iodinated contrast. Dose distribution was calibrated by thermoluminescence dosimetry. The uncertainty of in vitro determinations of the activity-dose dependence was {+-} 15-30%. The animal experiments were performed on rabbits with induced hypercholesterolemia. The {sup 32}P sources were introduced into a randomly chosen (left or right) iliac artery, immediately after balloon injury. Due to the low specific activity of the applied sources, the estimated 7-49 Gy doses on the internal artery surface required 30-100 min irradiations. A symmetric, balloon-occluded but non-irradiated artery of the same animal served as control. Radiation effects were evaluated by comparing the thicknesses of various components of irradiated versus untreated artery walls of each animal. The treatment was well tolerated by the animals. The effects of various dose ranges could be distinguished although differences in individual biological reactions were large. Only the 49 Gy dose at 'zero' distance (16 Gy at 1.0 mm from the balloon surface) reduced hypertrophy in every active layer of the artery wall. The cross-sectional intimal thicknesses after 7, 12, 38 and 49 Gy doses were 0.277, 0.219, 0.357 and 0.196 mm{sup 2} respectively, versus 0.114, 0.155, 0.421 and 0.256 mm{sup 2} in controls (p < 0.05). The lowest radiation dose on the intima induced the opposite effect. Edge intimal hyperplasia was not avoided, which agrees with other reports. The edge restenosis and the variability of individual response to identical treatment conditions must be considered as limitations of the post-dilatation IVBT method. Only application of highest irradiation doses was effective. The irradiation dose should be planned and calculated for adventitia.

• OSTI ID: 21088315
• Journal Information: Cardiovascular and Interventional Radiology, Journal Name: Cardiovascular and Interventional Radiology Journal Issue: 1 Vol. 27; ISSN 0174-1551; ISSN CAIRDG
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ARTERIES
BRACHYTHERAPY
HYPERTROPHY
INJURIES
IRRADIATION
PHOSPHATES
RABBITS
RADIATION DOSE DISTRIBUTIONS
RADIATION DOSES
SODIUM CHLORIDES
THERMOLUMINESCENT DOSIMETRY
THICKNESS