Engineering Radioactive Stents for the Prevention of Restenosis
- University of Wisconsin-Madison
Radiation has become an accepted treatment for the prevention of restenosis (re-blockage) of coronary arteries following angioplasty. Radioactive stents could be the easiest method of delivery for the radiation, although clinical trials were disappointing. One likely reason was the choice of P-32 as the radionuclide, which fails to match the biological needs of the problem. What radionuclide would perform best remains unknown. This project established the physical infrastructure necessary for a rational investigation to determine the optimum radiological characteristics for radioactive stents in the prevention of restenosis following angioplasty. The project investigated methods to activate coronary stents with radionuclides that spanned a range of energies and radiation types that could provide a mapping of the biological response. The project also provided calibration methods to determine the strength of the stents, an a process to calculate the dose distribution actually delivered to the patient's artery--quantities necessary for any future scientific study to improve the effectiveness of radioactive stents. Such studies could benefit the thousands of patients who receive angioplasty each year.
- Research Organization:
- University of Wisconsin-Madison, Madison, WI (US)
- Sponsoring Organization:
- Nuclear Science (US)
- DOE Contract Number:
- FG07-01ID14107
- OSTI ID:
- 831121
- Report Number(s):
- DOE/ID14107-3
- Country of Publication:
- United States
- Language:
- English
Similar Records
Boron neutron capture therapy for the prevention of restenosis
Endovascular Stenting for Restenosis of the Intracranial Vertebrobasilar Artery After Balloon Angioplasty: Two Case Reports and Review of the Literature
Use of Reactor-Produced Radioisotopes for Prevention Restenosis After Angioplasty
Journal Article
·
Sun Nov 30 23:00:00 EST 1997
· Transactions of the American Nuclear Society
·
OSTI ID:552349
Endovascular Stenting for Restenosis of the Intracranial Vertebrobasilar Artery After Balloon Angioplasty: Two Case Reports and Review of the Literature
Journal Article
·
Wed Sep 15 00:00:00 EDT 2004
· Cardiovascular and Interventional Radiology
·
OSTI ID:21088208
Use of Reactor-Produced Radioisotopes for Prevention Restenosis After Angioplasty
Technical Report
·
Mon Dec 20 23:00:00 EST 1999
·
OSTI ID:760343
Related Subjects
07 ISOTOPE AND RADIATION SOURCES
43 PARTICLE ACCELERATORS
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY
60 APPLIED LIFE SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ARTERIES
BRACHYTHERAPY CALIBRATION
BRACHYTHERAPY DOSIMETRY
CALIBRATION
CLINICAL TRIALS
INTRAVASCUALR BRACHYTHERAPY
INTRAVASCULAR BRACHTHERAPY DOSE CALCULATIONS
PATIENTS
RADIATION DOSE DISTRIBUTIONS
RADIATIONS
RADIOACTIVE STENTS
RADIOISOTOPES
43 PARTICLE ACCELERATORS
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY
60 APPLIED LIFE SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ARTERIES
BRACHYTHERAPY CALIBRATION
BRACHYTHERAPY DOSIMETRY
CALIBRATION
CLINICAL TRIALS
INTRAVASCUALR BRACHYTHERAPY
INTRAVASCULAR BRACHTHERAPY DOSE CALCULATIONS
PATIENTS
RADIATION DOSE DISTRIBUTIONS
RADIATIONS
RADIOACTIVE STENTS
RADIOISOTOPES