Boron neutron capture therapy for the prevention of restenosis

Journal Article · Mon Dec 01 04:00:00 EST 1997 · Transactions of the American Nuclear Society

OSTI ID:552349

Yanch, J C; Delfaus, M L ^[1]

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1. Massachusetts Institute of Technology, Cambridge, MA (United States)

The potential application of boron neutron capture therapy (BNCT) for the prevention of restenosis following angioplasty is under investigation at Massachusetts Institute of Technology`s Laboratory for Accelerator Beam Applications. The process of Percutaneous transluminal coronary angioplasty involves the insertion of a balloon dilation catheter into the occluded artery. The balloon is then inflated for several minutes to dilate the artery. The blockage is decreased, and blood flow through the artery is improved. This procedure is, initially, very successful. However, 30 to 60% of patients treated also show restenosis within 6 months. Although many physiological processes may contribute to restenosis, the primary mechanism is thought to be abnormal proliferation of the smooth muscle cells in the treated artery.

• OSTI ID: 552349
• Report Number(s): CONF-971125--
• Journal Information: Transactions of the American Nuclear Society, Journal Name: Transactions of the American Nuclear Society Vol. 77; ISSN 0003-018X; ISSN TANSAO
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
ANIMAL CELLS
BLOOD FLOW
BORON
CARDIOVASCULAR DISEASES
MUSCLES
NEUTRON CAPTURE THERAPY
RADIATION DOSES