Rapid droplet introduction interface (RDII) for mass spectrometry

Kertesz, Vilmos; Cahill, John F.

Rapid droplet introduction interface (RDII) for mass spectrometry

Patent · Tue May 16 04:00:00 EDT 2023

OSTI ID:1998379

Kertesz, Vilmos; Cahill, John F.

A system for the mass spectrometry analysis of an analyte includes a droplet ejection device, a spray head comprising a spray tip for ejecting the solvent as a spray, and a solvent delivery conduit for delivering solvent to the spray tip. The spray head includes a droplet inlet opening communicating with the surrounding atmosphere for receiving liquid droplets comprising the analyte. The droplet ejection device selectively ejects a liquid analyte droplet comprising the analyte through a surrounding atmosphere and the droplet inlet opening into a solvent flowing through the solvent delivery conduit. A method for the mass spectrometry analysis of an analyte is also disclosed.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC05-00OR22725

Assignee:: UT-Battelle, LLC (Oak Ridge, TN)

Patent Number(s):: 11,651,945

Application Number:: 17/480,094

OSTI ID:: 1998379

Country of Publication:: United States

Language:: English

References (14)

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Rapid sample classification using an open port sampling interface coupled with liquid introduction atmospheric pressure ionization mass spectrometry: Sample classification using an open port sampling interface Van Berkel, Gary J.; Kertesz, Vilmos Rapid Communications in Mass Spectrometry, Vol. 31, Issue 3 https://doi.org/10.1002/rcm.7792	journal	January 2017
Immediate drop on demand technology (I-DOT) coupled with mass spectrometry via an open port sampling interface Van Berkel, Gary J.; Kertesz, Vilmos; Boeltz, Harry Bioanalysis, Vol. 9, Issue 21 https://doi.org/10.4155/bio-2017-0104	journal	November 2017
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Drop-on-Demand Sample Introduction System Coupled with the Flowing Atmospheric-Pressure Afterglow for Direct Molecular Analysis of Complex Liquid Microvolume Samples Schaper, J. Niklas; Pfeuffer, Kevin P.; Shelley, Jacob T. Analytical Chemistry, Vol. 84, Issue 21 https://doi.org/10.1021/ac3020164	journal	October 2012
Combined Falling Drop/Open Port Sampling Interface System for Automated Flow Injection Mass Spectrometry Van Berkel, Gary J.; Kertesz, Vilmos; Orcutt, Matt Analytical Chemistry, Vol. 89, Issue 22 https://doi.org/10.1021/acs.analchem.7b03899	journal	November 2017
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High-Throughput Nanoelectrospray Ionization-Mass Spectrometry Analysis of Microfluidic Droplet Samples Steyer, Daniel J.; Kennedy, Robert T. Analytical Chemistry, Vol. 91, Issue 10 https://doi.org/10.1021/acs.analchem.9b00571	journal	April 2019
An open port sampling interface for liquid introduction atmospheric pressure ionization mass spectrometry: Open port sampling interface Van Berkel, Gary J.; Kertesz, Vilmos Rapid Communications in Mass Spectrometry, Vol. 29, Issue 19 https://doi.org/10.1002/rcm.7274	journal	August 2015

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